It depends. Most people take nucs for 3-5 years. Then stop if dna is undtectable. Then you monitor your responce. If immune system is holding the virus. You.may not need treatment for some time. But in most cases with nucs virus comes back.
Only interferon has the ability to give a sustained responce and clear hbv.
They prescribe us nucs because it is popular now. But the truth is only people with advanced liver disease need them .
Healthy young people.should do interferon treatment of 6-12 months. Sometimes repeated course helps.
it makes no sense to stop it wasting the chance to clear hbv definitively, if you are on viread for 2-3 years add on peginterferon to it and follow how hbsag clears on this combo by checking hbsag quant every 3 months
make sure your vitd25oh is 80-90ng/ml if not take vit d3 5000 to 10.000iu daily to increase it and vit k2 400mcg to reguate calcium kinetics
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