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what makes the HBV Vaccine work in immue system
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what makes the HBV Vaccine work in immue system

My partner has taken 2 HBV shots. But unfortunately, He had done a blood test recently. It shows that his immue system is not working to reaponse the vaccine. The doctor said that he was equal to no protection against HVB virue in his body. I wonder what  can he do to make  the vaccine  react in his body? Thanks for any anwers
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Avatar_m_tn
HBV vaccination is a 3-shot series. So he should talk to his doctor to consider the following:
1. Complete the series
2. If still no antibodies, consider a second series, higher doses, inject intramuscular, add HBIG
3. Finally there is a more powerful HBV vaccine called Sci-b-vac from Israel's SciVac.

The following is from:
http://hepbblog.org/2011/09/29/hbv-vaccine-non-responder-alternatives/

Options for HBV Vaccine Non-Responders
Posted on September 29, 2011 | 30 Comments




Are you a hepatitis B vaccine non-responder? Approximately 5-15% of people who receive the vaccine are considered non-responders. This is especially important for health care workers, families living in households with people that have HBV, and others who may be at increased risk of exposure to HBV.  A vaccine non-responder is someone that does not build up an adequate immune response after receiving two, 3-shot series of the HBV vaccine.  In other words, they complete one series of the HBV vaccine, and follow it with a surface antibody test (HBsAb or Anti-HBs) 4-6 weeks following the last injection of the series.  If the anti-HBs titre is not greater than 10IU/l, than the series is repeated, preferably with an HBV vaccine from a different manufacturer, and the person is once again tested for immunity by testing for adequate anti-HBs. (See previous blog, “Got Hepatitis B? Keeping loved ones safe though HBV vaccination” for details)

Fortunately there are other options for those concerned with being an HBV vaccine non-responder. There is a higher concentration of the HBV vaccine recommended by the CDC that is used for patients undergoing dialysis, and for those that are immune suppressed.  It is a 40µg/ml concentration. If it has been one year or less since you completed the three-shot series of the regular concentration of the vaccine, you can try one intramuscular dose of 1.0 ml of the 40µg HBV vaccine.  If it has been more than one year since your last three shot series of the vaccine, you can repeat the entire three-shot series with the 40µg concentration of the vaccine.  Follow up with an anti-HBs titre test 4 to 6 weeks following the last injection to ensure it is greater than 10 IU/l, and that you have adequate immunity.

If you continue to remain a non-responder, you can try a series of as many as five intra-dermal injections, given every two weeks, using the 40µg concentration of the HBV vaccine.  Dose one consists of 0.10 ml of the 40µg/ml vaccine, followed by the same dose two 2-weeks later.  At that time an anti-HBs titre test would be drawn to check for immunity.  If there was not adequate immunity, a third-intra-dermal dose of the vaccine would be given two weeks later.  Anti-HBs titres would be checked every two weeks and the patient would be given another intra-dermal injection up to a total of 5 intradermal injections of the 40µg concentration of the HBV vaccine. Don’t forget to ensure that your anti-HBs titre is greater than 10IU/l.

Please note that the schedule for the series might vary depending on the study your doctor chooses to follow.  However, it is recommended that the higher concentration (40µg) of the hepatitis B vaccine be used for best results.
This entry was posted in Hep B Prevention, Vaccines and tagged adoption, HBV, HBV vaccine, HCW, health care workers, Hepatitis B, hepatitis B vaccine, intradermal HBV vaccine, vaccine non-responder. Bookmark the permalink.
12 Comments Post a Comment
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Avatar_m_tn
HBV vaccination is a 3-shot series. So he should talk to his doctor to consider the following:
1. Complete the series
2. If still no antibodies, consider a second series, higher doses, inject intramuscular, add HBIG
3. Finally there is a more powerful HBV vaccine called Sci-b-vac from Israel's SciVac.

The following is from:
http://hepbblog.org/2011/09/29/hbv-vaccine-non-responder-alternatives/

Options for HBV Vaccine Non-Responders
Posted on September 29, 2011 | 30 Comments




Are you a hepatitis B vaccine non-responder? Approximately 5-15% of people who receive the vaccine are considered non-responders. This is especially important for health care workers, families living in households with people that have HBV, and others who may be at increased risk of exposure to HBV.  A vaccine non-responder is someone that does not build up an adequate immune response after receiving two, 3-shot series of the HBV vaccine.  In other words, they complete one series of the HBV vaccine, and follow it with a surface antibody test (HBsAb or Anti-HBs) 4-6 weeks following the last injection of the series.  If the anti-HBs titre is not greater than 10IU/l, than the series is repeated, preferably with an HBV vaccine from a different manufacturer, and the person is once again tested for immunity by testing for adequate anti-HBs. (See previous blog, “Got Hepatitis B? Keeping loved ones safe though HBV vaccination” for details)

Fortunately there are other options for those concerned with being an HBV vaccine non-responder. There is a higher concentration of the HBV vaccine recommended by the CDC that is used for patients undergoing dialysis, and for those that are immune suppressed.  It is a 40µg/ml concentration. If it has been one year or less since you completed the three-shot series of the regular concentration of the vaccine, you can try one intramuscular dose of 1.0 ml of the 40µg HBV vaccine.  If it has been more than one year since your last three shot series of the vaccine, you can repeat the entire three-shot series with the 40µg concentration of the vaccine.  Follow up with an anti-HBs titre test 4 to 6 weeks following the last injection to ensure it is greater than 10 IU/l, and that you have adequate immunity.

If you continue to remain a non-responder, you can try a series of as many as five intra-dermal injections, given every two weeks, using the 40µg concentration of the HBV vaccine.  Dose one consists of 0.10 ml of the 40µg/ml vaccine, followed by the same dose two 2-weeks later.  At that time an anti-HBs titre test would be drawn to check for immunity.  If there was not adequate immunity, a third-intra-dermal dose of the vaccine would be given two weeks later.  Anti-HBs titres would be checked every two weeks and the patient would be given another intra-dermal injection up to a total of 5 intradermal injections of the 40µg concentration of the HBV vaccine. Don’t forget to ensure that your anti-HBs titre is greater than 10IU/l.

Please note that the schedule for the series might vary depending on the study your doctor chooses to follow.  However, it is recommended that the higher concentration (40µg) of the hepatitis B vaccine be used for best results.
This entry was posted in Hep B Prevention, Vaccines and tagged adoption, HBV, HBV vaccine, HCW, health care workers, Hepatitis B, hepatitis B vaccine, intradermal HBV vaccine, vaccine non-responder. Bookmark the permalink.
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Avatar_m_tn
scivac will work for sure but if you have no access to it you may try also:
increasing vitamin d by taking 10.000iu of d3 daily and then check vitd25oh level after 4 weeks of supplementation, the target value is 60-100ng/ml

if it doesn t work add to vitamin d aldara cream on the site of injection

unfortunately the hbv vaccine is made very bad, it has only one of the 3 hbsag antigens which are very poor immunogenic so there is a high rate of failure to this vaccine

new vaccines are made with the 3 hbsag antigens, like scivac or with hbcag which is very immunogenic like the cuban vaccine.marketing of these vaccines is being very slow unfortunately, probably commercial reasons behind it
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Avatar_f_tn
thanks for ur reply. I will read more about this information. I hope there is some medicine for those who are HBV carriers. It is more helpful for most of the carriers
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Avatar_m_tn
you dont have to worry too much, adults clear hbv by immune system, it is only infected at birth that you get chronic hbv

of course there are antivirals to block hbv and treatments to cure it
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Avatar_m_tn
Propably I was infected when I was 24.
Now I am 34 and i m chronić unfortanetuly :(
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Avatar_m_tn
only 2,8% of adults cannot clear hbv, if you have no tests to prove you were clear at birth and very young it is very very unlikely you got it later
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Avatar_f_tn
sorry to hear that, I am a HBV carrier, but not serious. Doctor suggested that I dont have any treatment now. there are some treatment for those who  suffer from chronic. some of them can cure by some treatment. For me, I also want to take medicine if i can. As i can feel that , noone would accept me. I feel hopeless
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Avatar_m_tn
you need to monitor liver damage by fibroscan every 6 to 12 months and ultrasound every 6 month for cancer.if fibroscan is not normal you need treatment

only fibroscan can tell if there is liver damage, no ultrasound and no blood tests can tell.normal alt does not mean no damage
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Avatar_m_tn
I didn't make any tests before last one (2 months ago) so its can be that I was infected like a young (i was in hospital when i was 7 and after took 3 years injections, maybe a lot of vists by dentist like a child ). I have any prove when and why, only my suggests.
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Avatar_m_tn
I got infected at 25.  And now I'm 35, and chronically infected, although in an inactive carrier state.  

What's really surprising to me is that I was tested at 19 before starting work in a hospital and was negative, and received three shots of the vaccine.  I think I was given the child dose since I was 19, as that was the cut-off age for that dose level, and I've wondered if that may be why the vaccine didn't work for me.
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Avatar_m_tn
Very, very, very strange.
You had vaccine and got infected.

I do not know what happened.
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Avatar_f_tn
It was mostly likely because the vaccine  doesnt react into your body. Maybe ,
the level of the anti- body will reduce for a long time. So once u have got

vaccine, u also need to check how much anti-body level u have in your

immune system against the viruses. My partner"s case was that he got 2

shots of vaccine, but there is no anti-body in his immune system. Can any

one tell me how the age affect the vaccine react in the body? If someone

improve the immune system by having healthy food and maintain healthy

life , will it affect the vaccine to react in the body again?  
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