steff, do you see any advantage of adding simvastatin with peg interferon. if addition is beneficial the please give dosing information and if any other add-on which can boost interferon effect vitamins,nitazoxanide or minerals etc.
hbsag quantity is the only sure predictor of response but otan tried adding sim at the begining of tretment about 20mg daily and response was superfast, you may try too but we have no human trials to prove thi is true we have to do the trial on ourselves (no drug maker will ever pay trials on sim)
one effect of intf is the lowering of cholesterol, especially cellular cholesterol, sim may help on this or have some effect on reinfection, anyway if you have low hbsag like otan did it makes sense to try it
vit d3 >50ng/ml is proven to boost response and also about 4 cups of coffee per day
i dont remember, there was a study just published about this but i dont remember values, they found that highest hbsag/hbvdna was correlated with slow hbsag clearance and development of chronic hbv in about 3-4% adults
coffee is reported to boost pegintf response on hcv trials as vitd, i guess coffee is able to manage insuline resistance and glucose which are not to suppress immune system, coffee suppresses the picks of glucose especially green coffee which is not roosted but raw, studies also reported the compound responsible for this but i dont remember it
another italian study reported green coffee to help lose weight on a diet
steff, your detail views on this..suppose one gets hbsag reduction by x% (given x% is not very optimistic value) after shots of interferon what do you think after stopping interferon that new hbsag value will be maintained or the hbsag will jump to the base line value? please provide conditional answer.
and what are the considering parameters (given virs load is already nill due to nucs) which will define that decline will be continue or decline would be stopped after stopping interferon?
stopping interferon that new hbsag value will be maintained or the hbsag will jump to the base line value?
it can be anything there is no answer to this if there is no pegintf response, only a very low hbsag might be mainteined for sure under nucs like 100-300iu/ml
in theory the new level of hbsag should be maintenined but there are no studies to answer this
which will define that decline will be continue or decline would be stopped after stopping interferon?
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