what to add with interferon

[newtr]

steff, do you see any advantage of adding simvastatin with peg interferon. if addition is beneficial the please give dosing information and if any other add-on which can boost interferon effect vitamins,nitazoxanide or minerals etc.

[newtr]

any difference in  peg alpha a and b..in our experience?

[stef2011]

stopping  interferon that new hbsag value will be maintained or the hbsag will jump to the base line value?

it can be anything there is no answer to this if there is no pegintf response, only a very low hbsag might be mainteined for sure under nucs like 100-300iu/ml
in theory the new level of hbsag should be maintenined but there are no studies to answer this

which will define that decline will be continue or decline would be stopped after stopping interferon?

again no studies to define this yet, too early

[newtr]

steff, your detail views on this..suppose one gets hbsag  reduction by  x% (given x% is not very optimistic value) after shots of interferon what do you think after stopping  interferon that new hbsag value will be maintained or the hbsag will jump to the base line value? please provide conditional answer.
and what are the considering parameters (given virs load is already nill due to nucs) which will define that decline will be continue or decline would be stopped after stopping interferon?

[stef2011]

coffee is reported to boost pegintf response on hcv trials as vitd, i guess coffee is able to manage insuline resistance and glucose which are not to suppress immune system, coffee suppresses the picks of glucose especially green coffee which is not roosted but raw, studies also reported the compound responsible for this but i dont remember it

another italian study reported green coffee to help lose weight on a diet

[stef2011]

yes it is a responder but it is best to see at 12 and 24 weeks

[mustthinkpositive]

What is the theory behind the 4 coffee?

[newtr]

stef, is less than 0.5 Log reduction in hbsag in one month with interferon can be regarded as non responder, and should interferon be stopped in such cases?

[stef2011]

i dont remember, there was a study just published about this but i dont remember values, they found that highest hbsag/hbvdna was correlated with slow hbsag clearance and development of chronic hbv in about 3-4% adults

[newtr]

stef, whatis typical maximum hbsag quant.  in acute phase of people who able to clear? any rough guess.

[stef2011]

does selinium and zink helpful ?
yes, they are needed by immune system, sel 300-400 and zinc 30, sorry but i dont remember now if mg or mcg but they are already sold in the correct amount of mcg or mg

vit c, liposomal or injectable yes

[newtr]

does selinium and zink helpful ? i found somewhere that selinium is called as virus control pil. is these actually helpful? and vit c?

[stef2011]

iron is not good and vit E i dont know i dont think there are studies on it but i dont see how it can boost intf response

[newtr]

is iron , vit E contraindicated with interferon? as vit E is anti-nflammatory.

[stef2011]

hbsag quantity is the only sure predictor of response but otan tried adding sim at the begining of tretment about 20mg daily and response was superfast, you may try too but we have no human trials to prove thi is true we have to do the trial on ourselves (no drug maker will ever pay trials on sim)

one effect of intf is the lowering of cholesterol, especially cellular cholesterol, sim may help on this or have some effect on reinfection, anyway if you have low hbsag like otan did it makes sense to try it

vit d3 >50ng/ml is proven to boost response and also about 4 cups of coffee per day