Aa
wow found post of a guy who cleared after 48weeks combo interferon+telbivudine in italy
one of the protocols i am about to join with interferon+ potent nucs like tenofovir, entecavir, telbivudine.....so good to know some patients who strated this in 2010 cleared hbv already in just 48weeks
http://forum.corriere.it/fegato/03-12-2011/sono-guarito-e-ora-1941898.html
generics ara available in india already
good, iam from saudi arabia ... i didnt find generics here ..
good, iam from saudi arabia ... i didnt find generics here ..
only if hbvdna already undetactable otherwise response to interferon is poor:
most potent:
interferon+tenofovir
interferon+entecavir
interferon+telbivudine (only research center with close monitoring for myophaty)
addition of alinia to these combos probably increase clearance and response, alinia has no relevant sides
generics are available in india already
of course without hbsag quantity this therapy cant be done
what is the commercial name of telbivudine?
what is the more potent: viread(tenovovir), barcluide ( enticavir) or telbivuidine?
which one of the are the safest?
if the patent is expired, will thier prices go down? how much do you think one pack of barcluide if the patent expired?
what is the more potent: viread(tenovovir), barcluide ( enticavir) or telbivuidine?
which one of the are the safest?
if the patent is expired, will thier prices go down? how much do you think one pack of barcluide if the patent expired?
on EASL presentation the advice was "concomitant use of PegIFN+LDT should be avoided at present" and this was to all doctors not tho the research centers- avoided not means forbidden and I think that they suspect that this can came from another cause that can be found and eliminate in future.
So, in my opinion, the usage of PegIFN+LDT in a trial (controlled environment) is safe and can bring many benefits, as the action of LDT is a good one. I read a lot of good reports for LDT action and the only bad one was related to some possible resistance, but it seams that this can be avoided in future if the sequencing will be used.
maybe next step is a combo, but a personalized combo (base on sequenceing, hbsag, hbeag, alt, ast, fibroscan, age, ... other ... )
So, in my opinion, the usage of PegIFN+LDT in a trial (controlled environment) is safe and can bring many benefits, as the action of LDT is a good one. I read a lot of good reports for LDT action and the only bad one was related to some possible resistance, but it seams that this can be avoided in future if the sequencing will be used.
maybe next step is a combo, but a personalized combo (base on sequenceing, hbsag, hbeag, alt, ast, fibroscan, age, ... other ... )
some italian researchers used it anyway with accurate monitoring, they used sequential treatments or short periods combo.
it has been noted telbivudine has also an effect on immune function, not just suppression of hbv, so i think they used this sequence adding interferon exactly when hbv immune response was rescued by telbivudine.
i know one trial like this was held in my home town too but i dont know if the data has been shown internationally, they have also a national network for hbv-hcv so maybe data on these trials is only shared in italian national network research on hbv-hcv
same was reported on EASL http://www.kenes.com/easl2010/orals/118.htm and also discussed at that time http://www.medhelp.org/posts/Hepatitis-B/do-not-forgetinterferontelbivudine-sebvivo-hbsag-clearance/show/1549615
the peripheral neurophaty (have to see exactly what this meant) issue was discussed also on medhelp http://www.medhelp.org/posts/Hepatitis-B/Telbivudine-peg-interferon-risk/show/473115 - but it can be because of the telbivudine and not because of combo
inf+telbivudine - it wasn't a big phase 3 trial, couple of years ago and was stooped as I remember they say something regarding problems on peripheral neurophaty or something like that.
have to look for this one
have to look for this one
there is not much difference in results when potent nucs and interferon are used but of course hbeag positive have intact immune response to hbv because hbv has not mutated yet, so definitely better be hbeag pos
the key is hbsag decrease monitoring and interferon extension until negative
thx stef this news are awesome.. I read that this guys underwent SEBIVO and not TFV... you know what i mean.. it'd be interstign knowing whether this guy was eag+ or not prior to therapy...
ENT+INF report for b+d (both clear): http://www.medhelp.org/posts/Hepatitis-B/entecavir--pegasys-for-hepatitis-BD/show/1487355#post_6759673
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