Aa
24 week treatment
At what point do they decide if you have to go a full 48 weeks instead of 24 I was told 24 week but then she said unless you stop the Victrelis and go a full 48 thats confusing to me so which is it 24 or 48 I dont think I can go another 24 weeeks thinking that was when i am done. I helped a lady in a car wreck I had no gloves shame on me.
Oh no, nevah-mind, I think you are on shot 11, from your last post~
Hey, I just wanted to come back and say that is so sad that you caught this disease from helping a lady who had a car accident.
Sometimes it seems like "no good deed goes unpunished"
I took CPR and Life-Saving, here in the San Francisco Bay Area, a couple times, and the second time was after HIV had come out. My Instructor drilled it into us, that we shouldn't even attempt to do mouth-to-mouth recessitation, with-out using this thick rubber dental dam type of thingee, to protect us from having contact with a strangers fluids, the old Universal Precautions rule.
I hope you are Und at 12 weeks, and only have to do the 28 weeks.
Hey, I just wanted to come back and say that is so sad that you caught this disease from helping a lady who had a car accident.
Sometimes it seems like "no good deed goes unpunished"
I took CPR and Life-Saving, here in the San Francisco Bay Area, a couple times, and the second time was after HIV had come out. My Instructor drilled it into us, that we shouldn't even attempt to do mouth-to-mouth recessitation, with-out using this thick rubber dental dam type of thingee, to protect us from having contact with a strangers fluids, the old Universal Precautions rule.
I hope you are Und at 12 weeks, and only have to do the 28 weeks.
Like it says up there,if you are Undetected at 8 weeks, and Undetected at 24 weeks, then it is a 28 week done deal, because dont forget, with Victrelism we have a "4 week lead in"
Were you Undetected at 4 weeks? I think you are waiting for your 8 week results, right?
Were you Undetected at 4 weeks? I think you are waiting for your 8 week results, right?
5.5 Laboratory Tests
HCV-RNA levels should be monitored at Treatment Weeks 4, 8, 12, and 24, at the end of treatment, during treatment follow-up, and for other time points as clinically indicated. Use of a sensitive real-time reverse-transcription polymerase chain reaction (RT-PCR) assay for monitoring HCV-RNA levels during treatment is recommended. The assay should have a lower limit of HCV-RNA quantification of equal to or less than 25 IU per mL, and a limit of HCV-RNA detection of approximately 10 to 15 IU per mL. For the purposes of assessing Response-Guided Therapy milestones, a confirmed “detectable but below limit of quantification” HCV-RNA result should not be considered equivalent to an “undetectable” HCV-RNA result.
Complete blood count (with white blood cell differential counts) must be conducted in all patients prior to initiating VICTRELIS combination therapy. Complete blood counts should be obtained at Treatment Weeks 4, 8, and 12, and should be monitored closely at other time points, as clinically appropriate.
Refer to the Package Inserts for peginterferon alfa and ribavirin, including pregnancy testing requirements.
Add VICTRELIS 800 mg (four 200-mg capsules) orally three times daily (every 7-9 hours) to peginterferon alfa and ribavirin regimen after 4 weeks of treatment. Based on the patient's HCV-RNA levels at Treatment Week (TW) 8, TW12 and TW24, use the following Response-Guided Therapy (RGT) guidelines to determine duration of treatment (see Table 1).
Table 1
Duration of Therapy Using Response-Guided Therapy (RGT)
Previously Untreated Patients (HCV-RNA Results) At Treatment Week 8 Undetectable At Treatment Week 24 Undetectable
RECOMMENDATION Complete three-medicine regimen at TW28.
(HCV-RNA Results) At Treatment Week 8 Detectable At Treatment Week 24 Undetectable RECOMMENDATION
1. Continue all three medicines and finish through TW36; and then
2. Administer peginterferon alfa and ribavirin and finish through
TW48.
Previous Partial Responders or Relapsers
(HCV-RNA Results) At Treatment Week 8 Undetectable At Treatment Week 24 Undetectable RECOMMENDATION
Complete three-medicine regimen at TW36.
(HCV-RNA Results) At Treatment Week 8 Detectable At Treatment Week 24 Undetectable RECOMMENDATION
1. Continue all three medicines and finish through TW36; and then
2. Administer peginterferon alfa and ribavirin and finish through
TW48.
TREATMENT FUTILITY
If the patient has HCV-RNA results greater than or equal to 100 IU/mL at TW12, then discontinue three-medicine regimen.
If the patient has confirmed, detectable HCV-RNA at TW24, then discontinue three-medicine regimen.
http://www.merck.com/product/usa/pi_circulars/v/victrelis/victrelis_pi.pdf .
HCV-RNA levels should be monitored at Treatment Weeks 4, 8, 12, and 24, at the end of treatment, during treatment follow-up, and for other time points as clinically indicated. Use of a sensitive real-time reverse-transcription polymerase chain reaction (RT-PCR) assay for monitoring HCV-RNA levels during treatment is recommended. The assay should have a lower limit of HCV-RNA quantification of equal to or less than 25 IU per mL, and a limit of HCV-RNA detection of approximately 10 to 15 IU per mL. For the purposes of assessing Response-Guided Therapy milestones, a confirmed “detectable but below limit of quantification” HCV-RNA result should not be considered equivalent to an “undetectable” HCV-RNA result.
Complete blood count (with white blood cell differential counts) must be conducted in all patients prior to initiating VICTRELIS combination therapy. Complete blood counts should be obtained at Treatment Weeks 4, 8, and 12, and should be monitored closely at other time points, as clinically appropriate.
Refer to the Package Inserts for peginterferon alfa and ribavirin, including pregnancy testing requirements.
Add VICTRELIS 800 mg (four 200-mg capsules) orally three times daily (every 7-9 hours) to peginterferon alfa and ribavirin regimen after 4 weeks of treatment. Based on the patient's HCV-RNA levels at Treatment Week (TW) 8, TW12 and TW24, use the following Response-Guided Therapy (RGT) guidelines to determine duration of treatment (see Table 1).
Table 1
Duration of Therapy Using Response-Guided Therapy (RGT)
Previously Untreated Patients (HCV-RNA Results) At Treatment Week 8 Undetectable At Treatment Week 24 Undetectable
RECOMMENDATION Complete three-medicine regimen at TW28.
(HCV-RNA Results) At Treatment Week 8 Detectable At Treatment Week 24 Undetectable RECOMMENDATION
1. Continue all three medicines and finish through TW36; and then
2. Administer peginterferon alfa and ribavirin and finish through
TW48.
Previous Partial Responders or Relapsers
(HCV-RNA Results) At Treatment Week 8 Undetectable At Treatment Week 24 Undetectable RECOMMENDATION
Complete three-medicine regimen at TW36.
(HCV-RNA Results) At Treatment Week 8 Detectable At Treatment Week 24 Undetectable RECOMMENDATION
1. Continue all three medicines and finish through TW36; and then
2. Administer peginterferon alfa and ribavirin and finish through
TW48.
TREATMENT FUTILITY
If the patient has HCV-RNA results greater than or equal to 100 IU/mL at TW12, then discontinue three-medicine regimen.
If the patient has confirmed, detectable HCV-RNA at TW24, then discontinue three-medicine regimen.
http://www.merck.com/product/usa/pi_circulars/v/victrelis/victrelis_pi.pdf .
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