30 Percent Success Rate.withNew Medication

I was recently told there was only about a 30 percent success rate with the
new medications used in the triple med. treatment. Does that sound right.

If that is the case is there anything the patient can do to improve the odds
of SVR.

[hrsepwrguy]

The success rate % depends on many factors, have you treated before and if so did you relapse or a non responder, do you have cirrhosis, many factors involved. If you could give more info on your situation you can get a much clearer response.

[flcyclist]

Have you had a PCR to determine you're positive for HCV and your viral load?  Do you know the genotype of the virus and your genotype by taking the IL28B test?  Have you had a biopsy to determine the stage of fibrosis or cirrhosis?  Also age, insulin resistance, etc. and other medical conditions all come into play with the overall success.   Let us know what your plan is and many here can try to answer your question with more information provided.

[hrsepwrguy]

I see that you have treated before but could not find if you relapsed or was a non responder, also coundn't find liver condition, so I am posting a link to some vertex info, look in section 6 and it will answer some of the questions you have,also I will post links to incivek full prescribing info and to victrelis as well. All stats you are looking for should be there. Hope this helps

http://www.fda.gov/downloads/AdvisoryCommittees/CommitteesMeetingMaterials/Drugs/AntiviralDrugsAdvisoryCommittee/UCM252562.pdf

http://pi.vrtx.com/files/uspi_telaprevir.pdf

http://www.merck.com/product/usa/pi_circulars/v/victrelis/victrelis_pi.pdf

[Advocate1955]

As others have said, the chances for SVR with triple therapy with Incivek depends on whether or not you've been treated previously, and, if so, how you responded previously:

http://www.fda.gov/ForConsumers/ByAudience/ForPatientAdvocates/ucm256328.htm

Treatment Outcome All T12/PR48a  
SVR rate      
Prior relapsers 86%
Prior partial responders 59%
Prior null responders 32%

If you treated previously and did not respond, your chances of SVR with triple with Inc. are about 32%.  But if you were a partial responder with previous therapy, your chances increase to about 59%.

Let us know more about your previous response.

Advocate1955

[James10500]

You have been misinformed.

[Revalation]

I'm not sure what kind of response I had.
At eight weeks I was told the virus was noI detectable
At 12 weeks I was told it was detectable again.


Revalation

[Advocate1955]

I think you would be considered a partial responder, but I'm not sure.  That would be a question for your doctor.
Advocate1955

[pjhep80]

SVR rate      
Prior relapsers 86%
Prior partial responders 59%
Prior null responders 32%


didnt realize this i thought even for null responders the odds were better...

that's a bummer.... :(

[pjhep80]

but i bet there are not that many complete null responders, since so many here seem to be responding to treatment...

[SusieS2010]

"but i bet there are not that many complete null responders, since so many here seem to be responding to treatment".

That is null responders from previous treatments not treatment with triple therapy. Also, Revalation had breakthrough. He is not a partial responder according to the definitions.

[Revalation]

What does null responder mean.

I may be null. At 8 weeks I was undetected.
But a 12 it was once again detected.

My treatment was not the new triple med treatment.
I thought it was a breakthrough, but could if have anything to
with the test they used  to determine if I still had Hep C virus?
I kind of think if it went away even a little that was some response even if the
test was less accurate the first time. I'm not sure!!

What is the definition of a null responder.
I'll have to ask the doctor about this.
I was his nurse who made the 30% statement.
I fainted and I'm not talking figuratively..I fainted.

[Revalation]

Thanks I will read the stats you sent.
If I can get up the nerve.
I really been nervous after hearing the 30%success rate for null
and wondering if I'm null.

[can-do-man]

No you would not be a null responder since you had become und, sounds more like either a breakthrough patient or maybe a partial responder.

http://www.thebody.com/content/art46371.html

Null Responder: A null responder is someone who achieves little or no decrease in hepatitis C viral load during HCV treatment. Null responders are highly unlikely to respond to re-treatment with an interferon-based regimen.

Partial Responder: A partial responder is someone who experiences at least a 2-log decrease in hepatitis C viral load during HCV treatment. Partial responders are more likely to respond to re-treatment than non-responders or null responders.

[Advocate1955]

Relapse means that HCV became—and remained—undetectable during treatment, but reappeared within weeks to months after finishing it.  Since revalation was not undetected at the end of 12 weeks, didn't finish treatment.  Revalation had at least a 2 log drop and then an increase in VL.  That's why I think would be considered a partial responder, making chances for SVR 59% on triple.  A doctor could answer this for certain.
Advocate1955

[milliehepc]

What is a breakthrough?
just making sure I understand what it meand when someone has a "breakthrough"....
thanks much...millie

[can-do-man]

Discussion

A viral breakthrough occurs when a patient achieves

a response while on IFN therapy and then loses the

response despite continued IFN therapy. The cause of

viral breakthroughs is not well understood. The viral

breakthrough phenomenon might also be the result of

the development of IFN resistance or the emergence

of quasispecies that are less sensitive to IFN therapy.

www.la-press.com/redirect_​file.php?fileId=3349&filename=...

[willbb]

Hi millie..A  "breakthrough  non -response" : is when  one is treating and becomes detectable again after becoming undetectable ..while still treating...
Will

[willbb]

hey Cando.......

[Revalation]

downloaded information.
lots to read
great info
thanks a million


Reva

[Revalation]

Can test sensivitiy have a role to play in testing.
Could you be und with one test and then the virus
is still there when tested with a more sensitive test.
Meaning it was there all along but not detected by a less
sensitive testing medium.