Aa
A couple three questions
Checked my most recent, 08/09 Mon., CBC and VL tests and questions.
As background, I'm into shot # 32. I've had problems with platelets and WBC/ANC counts, having been taken off tx 3 times for one or the other or both. They put me on Neup, took me off, WBC crashed. Back on, off, crash. On, off crash. Finally on 1 shot a week for the last four weeks. This last CBC was the 1st since getting a regular schedule and I was very focused on getting the best set up so when they scheduled the blood draws less than 36 hours after the interferon shot. I didn't go but rather showed up days later when I thought it was more favorable to me. Long winded way of saying these numbers are less than 12 hours after the Neup shot skewing them to the high end.
WBC = 15.5
Seg Neut = 45 & Band = 46 ... making ANC 14105.
Am I reading this right? 500 is cutoff, making this ANC count stratospheric out of range on the high side? Think this would be a reason to interrupt tx?
****
Question about platelets. I have a history of low platelets. Highest was low 90's just prior to starting tx. After starting it's been in the 50 range some dips below to 43. Currently it's 44. There is a new doc at the Teaching Hospital here and in the previous CBC to this one the count was also in the 40's but via the Resident guy they let me skate. I'm hoping for the same this time. The real question is:
For the first time new form field and comment reading.
Platelet Comment: Few Large PLTS Seen.
What does that mean? The shelf life of PL's are fairly short at around 10 days to 2 weeks, right? What little I've read Large PLTS in quantity is a bad thing. Do these things get bigger as they age? If so shouldn't there be a good mix of both at any given time? Or is it just nothing?
****
A question about the VL. This is the third so far. The previous two came back saying
" RNA by PCR: " Less then 43 iu/ml
" Log of HCV RNA: " Less than 1.6
THIS time all it said was " HCV RNA by PCR: " HCV RNA not detected.
I presume it means the same as b4 but sure would like a big confirm on that!
****
Final question: should I have broke this up into different posts?
Thanks
As background, I'm into shot # 32. I've had problems with platelets and WBC/ANC counts, having been taken off tx 3 times for one or the other or both. They put me on Neup, took me off, WBC crashed. Back on, off, crash. On, off crash. Finally on 1 shot a week for the last four weeks. This last CBC was the 1st since getting a regular schedule and I was very focused on getting the best set up so when they scheduled the blood draws less than 36 hours after the interferon shot. I didn't go but rather showed up days later when I thought it was more favorable to me. Long winded way of saying these numbers are less than 12 hours after the Neup shot skewing them to the high end.
WBC = 15.5
Seg Neut = 45 & Band = 46 ... making ANC 14105.
Am I reading this right? 500 is cutoff, making this ANC count stratospheric out of range on the high side? Think this would be a reason to interrupt tx?
****
Question about platelets. I have a history of low platelets. Highest was low 90's just prior to starting tx. After starting it's been in the 50 range some dips below to 43. Currently it's 44. There is a new doc at the Teaching Hospital here and in the previous CBC to this one the count was also in the 40's but via the Resident guy they let me skate. I'm hoping for the same this time. The real question is:
For the first time new form field and comment reading.
Platelet Comment: Few Large PLTS Seen.
What does that mean? The shelf life of PL's are fairly short at around 10 days to 2 weeks, right? What little I've read Large PLTS in quantity is a bad thing. Do these things get bigger as they age? If so shouldn't there be a good mix of both at any given time? Or is it just nothing?
****
A question about the VL. This is the third so far. The previous two came back saying
" RNA by PCR: " Less then 43 iu/ml
" Log of HCV RNA: " Less than 1.6
THIS time all it said was " HCV RNA by PCR: " HCV RNA not detected.
I presume it means the same as b4 but sure would like a big confirm on that!
****
Final question: should I have broke this up into different posts?
Thanks
Nope,
Segment Neutrophil = 45 ... in the "Units" field it shows %
Band Netrophil = 46, expressed as %
After giving the component parts like lymphocyte, etc. it comes to ...
ABS Seg Neut = 6.98 .... in the "Units" field 10^3/UL
ABS Band Neut = 7.12 ... in the same units
Which numbers are used for ANC ?
Remember this was less than 12 hours after taking the Neup shot.
Segment Neutrophil = 45 ... in the "Units" field it shows %
Band Netrophil = 46, expressed as %
After giving the component parts like lymphocyte, etc. it comes to ...
ABS Seg Neut = 6.98 .... in the "Units" field 10^3/UL
ABS Band Neut = 7.12 ... in the same units
Which numbers are used for ANC ?
Remember this was less than 12 hours after taking the Neup shot.
"Other factors contributing to the neutrophilia induced by filgrastim include a substantial (e.g., ninefold) increase in neutrophil production rate, with several extra amplification divisions during neutrophil development, and a shortening (e.g., from the usual 4 or 5 days to 1 day) of the time required for neutrophil precursors to mature and appear in circulation."
http://www.medscape.com/druginfo/monograph?cid=med&drugid=9370&drugname=Neupogen+Inj&monotype=monograph&secid=7
http://www.medscape.com/druginfo/monograph?cid=med&drugid=9370&drugname=Neupogen+Inj&monotype=monograph&secid=7
Are you sure you got the bands percentage correct?
Usually, those little bands form a negligible part of the calculation. If it's 4.6 percent instead, then your ANC would be 7.68, high normal - amazing, given your recent crashes.
?
Usually, those little bands form a negligible part of the calculation. If it's 4.6 percent instead, then your ANC would be 7.68, high normal - amazing, given your recent crashes.
?
Can’t much help on the WBC stuff especially since some labs measure nuet breakdowns in % rather than in raw numbers; though I’ve never heard of anyone being taken off meds for high ANC during treatment ... did your doctor mention a ceiling for ANC?
My husband’s platelets skated down as low as 35, but that was at about week 70 or so… otherwise his platelets hovered in the 40s and 50s and the nurses and docs didn’t bat an eye. And, because he always did his bloodwork late Friday just before his shot, he ALWAYS had lots of large plts – that never raised an eyebrow either, at least not with this particular hepo.
And I’d certainly say that “Less than 43 iu/mL” = HCV RNA not detected. Sounds like you’re holding down the fort. Continued success to you.
~eureka
PS -Like the one post better than the idea of three.
My husband’s platelets skated down as low as 35, but that was at about week 70 or so… otherwise his platelets hovered in the 40s and 50s and the nurses and docs didn’t bat an eye. And, because he always did his bloodwork late Friday just before his shot, he ALWAYS had lots of large plts – that never raised an eyebrow either, at least not with this particular hepo.
And I’d certainly say that “Less than 43 iu/mL” = HCV RNA not detected. Sounds like you’re holding down the fort. Continued success to you.
~eureka
PS -Like the one post better than the idea of three.
There are entries on the form for SEG and BAND Neut's given in %. Those are the numbers I thought were supposed to be used.
There is another two entries for ABS SEG (and BAND) Neut's but in previous tests using those numbers would have given me a ANC of .0063. Pretty much being dead territory. I guess. Haha, different calculators put the decimal in different places or don't use them. Around 03:00 I'll figure it out. But it would be much easier if it were by % :)
There is another two entries for ABS SEG (and BAND) Neut's but in previous tests using those numbers would have given me a ANC of .0063. Pretty much being dead territory. I guess. Haha, different calculators put the decimal in different places or don't use them. Around 03:00 I'll figure it out. But it would be much easier if it were by % :)
Some answers, not all or in order.
The single post is fine. Eveyrthing in one place.
Don't worry about platelets bouncing around in the neighborhood of 50. At about 25, platelets would be attention getting. And it seems like you've located the floor of your range, 40 ish.
Many people have seen the 'big or clumping' comment. It likely means he sample was degraded or not handled soon enough. No big deal.
Not sure on your ANC math. I used to get cbc results requiring a calculation, but I don't think those are the right values to use. I have it but it's not accessible to me for a few days. Look on the report for term like 'ANC' or 'Absolute Neut' or ANC. Many doc and pts think ANC down to 300 in acceptable.
The single post is fine. Eveyrthing in one place.
Don't worry about platelets bouncing around in the neighborhood of 50. At about 25, platelets would be attention getting. And it seems like you've located the floor of your range, 40 ish.
Many people have seen the 'big or clumping' comment. It likely means he sample was degraded or not handled soon enough. No big deal.
Not sure on your ANC math. I used to get cbc results requiring a calculation, but I don't think those are the right values to use. I have it but it's not accessible to me for a few days. Look on the report for term like 'ANC' or 'Absolute Neut' or ANC. Many doc and pts think ANC down to 300 in acceptable.
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