ANA598

[m_strings]

I'm curious if anyone is enrolled in the ANA598 polymerase inhibitor trial or knows much about it?  I understand tx naive patients are being recruited for a Phase II study.  It sounds like a promising agent.    

[m_strings]

Thanks for the info!  

I was thrilled to hear about it.  It does look very promising.  I was asked to participate but unfortunately I'm still a couple of BMI points too high to qualify.  Just as well - I'm happy to wait until phase II results are in.  Hopefully that's in the not too distant future.  I must agree.  It does sound promising.      

Thanks again for your input!  You're a good Egg!  :>)  

[fried_egg]

200mg 4 week results were positive showing a distinct improvement in RVR used in combination with SOC.  Looking forward to the SVR results for the 12 week data of this cohort early 2010.  The 400mg cohorts begin dosing in January 2010.  Looking for the results of this study in second quarter 2010.  This could very well be the next break through in Hep C tx.

fried_egg

[m_strings]

Just found this additional info:  

ANA598 Demonstrates Positive 4-Week Results at 200 mg BID

56% of HCV Patients in Active Arm Achieved RVR in Ongoing Phase II Study

400 mg BID Cohort Now Open to Enroll


SAN DIEGO, Dec. 17 /PRNewswire-FirstCall/ -- Anadys Pharmaceuticals, Inc. (Nasdaq: ANDS) today announced preliminary results from a planned interim analysis of data at four weeks for the first dose cohort, 200 mg bid, in an ongoing Phase II study of ANA598 in combination with pegylated interferon and ribavirin (SOC) in HCV patients. 56% of patients receiving ANA598 plus SOC achieved undetectable levels of virus (<15 IU/ml) at week 4, known as Rapid Virological Response or RVR, compared to 20% of patients receiving placebo plus SOC.

(Retrieved from http://www.prnewswire.com/news-releases/ana598-demonstrates-positive-4-week-results-at-200-mg-bid-79490252.html.)