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Any post treament issues with Sovalsi and Olysio?
My husband will start Sovaldi and Olysio this coming month. I have read several post in different websites regarding the terrible sides ( Inteferon, Riva etc.) that many have to deal with even months and years after treatment. I would like to know how many in this site finished S & O and how they are doing post treatment. He is geno type 1a, small varices and mild portal hypertension but feels fine. His doctor wants him to start asap since he feels if he gets cured it could stop his progression of liver disease. I am very worried for him and I would hate to see him deal with the troubles others are having long term .
Hi and welcome. Your concern is the after effects of treatment with Sovaldi and Oyslio.
Lynn has hit the nail on the head in respect as to future outcome. Will also interject some of my thoughts as well.
The real concern is not treating. Liver Disease can have so many unwelcome lifelong debilitating effects, and we are so lucky to be in an era where Hep C can now be cured.
I did not treat with Sovaldi and Oyslio, but as a geno 2, took Sovaldi and the dreaded Ribavirin. It's been almost 5 months since treatment ended, and I feel great. Of the two choices above the Oyslio seems to have less future issues although similar. Personally I had autoimmune issues before treatment, and they still remain even tho I am now cured.
I believe what you are focusing in on is the lifelong effects some have after treating with interferon. The older vs the newer treatments are night and day.
Some of the reasons are that currently treating is of shorter duration, and finally they have figured out dosing questions and which combos are most effective as to illicit accuracy, and less lethal sides. Since your husband will not be getting interferon, ill long term after effects should not occur.
Your husband may or may not have any side effects while on treatment and after treatment ends. Personally when treatment ended, I still felt fatigue for a few months along with brain fog. Some of my Oyslio friends felt the same while others felt fine. From what I've read women, cirrhotics, persons age, and health history had mild to moderate degrees of severity of side effects.
When treatment ends, and the meds clear out (typically 1-2 months post) everyday gets better and better.
These are amazing drugs and they are saving people's lives. In the scheme of it all, a few months of unpleasant sides are so immaterial as compared to harboring a life threatening virus. Your husband should not expect any long term health related issues once treatment is over.
I wish you both well, and believe you will find tremendous health benefits in the long run.
...Kim
Lynn has hit the nail on the head in respect as to future outcome. Will also interject some of my thoughts as well.
The real concern is not treating. Liver Disease can have so many unwelcome lifelong debilitating effects, and we are so lucky to be in an era where Hep C can now be cured.
I did not treat with Sovaldi and Oyslio, but as a geno 2, took Sovaldi and the dreaded Ribavirin. It's been almost 5 months since treatment ended, and I feel great. Of the two choices above the Oyslio seems to have less future issues although similar. Personally I had autoimmune issues before treatment, and they still remain even tho I am now cured.
I believe what you are focusing in on is the lifelong effects some have after treating with interferon. The older vs the newer treatments are night and day.
Some of the reasons are that currently treating is of shorter duration, and finally they have figured out dosing questions and which combos are most effective as to illicit accuracy, and less lethal sides. Since your husband will not be getting interferon, ill long term after effects should not occur.
Your husband may or may not have any side effects while on treatment and after treatment ends. Personally when treatment ended, I still felt fatigue for a few months along with brain fog. Some of my Oyslio friends felt the same while others felt fine. From what I've read women, cirrhotics, persons age, and health history had mild to moderate degrees of severity of side effects.
When treatment ends, and the meds clear out (typically 1-2 months post) everyday gets better and better.
These are amazing drugs and they are saving people's lives. In the scheme of it all, a few months of unpleasant sides are so immaterial as compared to harboring a life threatening virus. Your husband should not expect any long term health related issues once treatment is over.
I wish you both well, and believe you will find tremendous health benefits in the long run.
...Kim
Just one more comment I noticed you are concerned about long term effects from the medicines.
For myself I am much more afraid of the effects of liver disease. It sounds like your husband is early cirrhosis and still essentially compensated as I am also. The consequences of becoming decompensated are frightening. Cirrhosis in considered ESLD (end stage liver disease) if your husband for example developed grade 3 varicies he would have a great risk of having a bleeding episode that could be fatal. He could develop hepatic encephalopathy which causes a greatly reduced quality of life and could also result in coma and death. Or if he is lucky he could receive a liver transplant saving his life but transplant is not without its own concerns and it truly is better if possible to keep the parts you start with if you can.
I tell you all this not to frighten you but to impress upon you the importance of curing his hep c before it can cause more damage to his liver. If he is able to cure hep c the is an opportunity for his liver to improve avoiding the dire consequences of ESLD and liver transplant.
Finally, although some here have reported having some side effects from Sovaldi Olysio many others like myself feel fine during and post treatment
Good luck
Lynn
For myself I am much more afraid of the effects of liver disease. It sounds like your husband is early cirrhosis and still essentially compensated as I am also. The consequences of becoming decompensated are frightening. Cirrhosis in considered ESLD (end stage liver disease) if your husband for example developed grade 3 varicies he would have a great risk of having a bleeding episode that could be fatal. He could develop hepatic encephalopathy which causes a greatly reduced quality of life and could also result in coma and death. Or if he is lucky he could receive a liver transplant saving his life but transplant is not without its own concerns and it truly is better if possible to keep the parts you start with if you can.
I tell you all this not to frighten you but to impress upon you the importance of curing his hep c before it can cause more damage to his liver. If he is able to cure hep c the is an opportunity for his liver to improve avoiding the dire consequences of ESLD and liver transplant.
Finally, although some here have reported having some side effects from Sovaldi Olysio many others like myself feel fine during and post treatment
Good luck
Lynn
Hi Dama
I have treated 3 times in the past first with interferon monotherapy 3 shots a week. Then two tries with interferon & Ribavirin ( one was a clinical drug trial with an experimental drug. I was a null responder to all prior treatments.
I am a 56 year old woman and have had hep c genotype 1a probably since 1977. I was diagnosed with cirrhosis in Jan 2008 and developed esophageal varicies that were banded. Also have some trace ascities and pitting edema so I take Spironolactone.
I treated from March to June 10th with Sovaldi Olysio and was undetectable at the end of treatment. I will be having my 12 week viral load test this Wednesday to see if I have eradicated the virus.
The Sovaldi Olysio treatment was nothing like my prior treatments with interferon. Other than being just 12 weeks instead of 12 weeks and just being pills without shots. I personally did not notice any side effects.
I may be just lucky some folks here reported varying amounts of sides but for many here we said the treatment was a piece of cake compared to the older therapies. Also the treatment is significantly more effective against hep c genotype 1 than anything available up till Nov/Dec 2013 when the drugs were approved.
Good luck to you both
Lynn
I have treated 3 times in the past first with interferon monotherapy 3 shots a week. Then two tries with interferon & Ribavirin ( one was a clinical drug trial with an experimental drug. I was a null responder to all prior treatments.
I am a 56 year old woman and have had hep c genotype 1a probably since 1977. I was diagnosed with cirrhosis in Jan 2008 and developed esophageal varicies that were banded. Also have some trace ascities and pitting edema so I take Spironolactone.
I treated from March to June 10th with Sovaldi Olysio and was undetectable at the end of treatment. I will be having my 12 week viral load test this Wednesday to see if I have eradicated the virus.
The Sovaldi Olysio treatment was nothing like my prior treatments with interferon. Other than being just 12 weeks instead of 12 weeks and just being pills without shots. I personally did not notice any side effects.
I may be just lucky some folks here reported varying amounts of sides but for many here we said the treatment was a piece of cake compared to the older therapies. Also the treatment is significantly more effective against hep c genotype 1 than anything available up till Nov/Dec 2013 when the drugs were approved.
Good luck to you both
Lynn
Hi, I did a search with the magnifying icon at the top of the page where you posted your question.
I am sending you the thread, in this there is another where many others have posted. Tell your hubby to keep drinking water.
My best to you
Dee
http://www.medhelp.org/posts/Hepatitis-C-Post-Treatment-Issues/post-solvaldi-tx---have-major-joint-pain-and-swellinh/show/2281571#post_10989970
I am sending you the thread, in this there is another where many others have posted. Tell your hubby to keep drinking water.
My best to you
Dee
http://www.medhelp.org/posts/Hepatitis-C-Post-Treatment-Issues/post-solvaldi-tx---have-major-joint-pain-and-swellinh/show/2281571#post_10989970
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