Anyone check their odds of SVR with a genetic profile?

  Its kinda spendy. About $500.00.  Then again maybe not if the test shows you don't have a chance of clearing.

Here is a sample report I received from them.

https://www.23andme.com/health/Hepatitis-C-Treatment-Response/

They break it down into 3 groups


Substantially lower odds       From 0.40 to 0.11 times typical odds/risk.

Moderately lower odds          From 0.66 to 0.41 times typical odds/risk.

Typical odds                        The odds, risk, or levels of subjects with the most common genotype.

[nygirl7]

Couldn't they just do that by geno? I guess it would be worth it if you knew it was really on target so you could wait for the PIs if you have the time and not build up any mutants ninja turtles right?  I would think the insurance would even be glad to pay it so that they didn't waste 100,000 on something that didn't have a chance!

[robo229]

How does one arrange for a genetic profile?  Is this something the hepatologist does or genetecist? CSI lab?

Robo

[Upbeat]

I believe you just send them a siliva sample then they do the test and send results.  I am going to email them and ask if will change when you add the new PI's into the mix.  When it comes right down to it its always been in the genes.  The only answer for why 15% clear it on their own.

[willing]

I was wondering when people would start using this...There was a recent discussion in a recent thread:
http://www.medhelp.org/posts/Hepatitis-C/Preliminary-EASL-Coverage-/show/1220912

note 23andme does not test the "main" SNP, rs12979860,  but another one nearby rs8099917 (presumably for patent reasons, but I'm not sure about that). More useful than their assessment would be the actual sequence at that SNP, which should be somewhere in the report (Upbeat - please post more of it if you have a chance) Translating SNP sequence to occurrence frequency to tx outcome is still pretty dicey with this data, so if you know your sequence you can keeping looking for updated correlation data as it becomes available.

One of the strengths of the rs12979860 analysis, is that it was based on the full IDEAL cohort, more than 1600 patients. So the odds there are pretty reliable (but of course it appears that's the one we can't read yet..).

Last year's Ge study is here:
http://www.ncbi.nlm.nih.gov/pubmed/19684573

a more recent update (this stuff is moving quickly) is:
http://www.ncbi.nlm.nih.gov/pubmed/20399780

[Mr Liver]

"NYgirl agrees with the posters before her.  I'd hate to put my life in the hands of something that hasn't been proven to be without flaw - not when it's this critical and seems like an awful lot of guessing. "

The above post was your response to me when I posted a study that showed success based on genetic testing predicting odds of SVR.
This is your response in this thread to the same concept:

" I guess it would be worth it if you knew it was really on target so you could wait for the PIs if you have the time and not build up any mutants ninja turtles right?  I would think the insurance would even be glad to pay it so that they didn't waste 100,000 on something that didn't have a chance! "

Any particular reason for the change of heart ?

ML

[susan400]

Actually, I don't really want to know.  Because if it came back that I couldn't clear this beast and then, it took away all my hope for a cure.., I'd just give up.  I don't need that.  At least w/o knowing, I still have my hope and I'd prefer to keep that hope.  Susan400

[copyman]

I actually did a test called CRS "cirrhosis risk score" a few years back before I treated.  it came back that I was 3 times likely to advance to cirrhosis because of my genes. After thinking about it I didn't need them to tell me that! It is common knowledge that a certain amount of people will advance to cirrhosis if you have HCV. It was one of the factors for me treating. It was always in the back of my mind that I had "cirrhosis genes".
It was an expensive test, I was lucky the insurance paid for it.

I think in the future these gene tests will be helpful but not much use at this time.