I am an African American male and I tried treatment with Peg/Ribaviron two times. Neither was succesful. I know that African Americans are poor responders. But how poor I can't figure out. Does anyone here actually know of an African American who has svr?
Hey Henry, I don't know the answer but what genotype are you and how long did you treat for? That can have a big effect on outcome as not all doctors are too swift at their jobs. I'm a 1a and treated 48 weeks with peg-intron and 1200mg ribavirin and relapsed.Hopefully someone will have useful info for you.Good luck, frank
Sorry to hear about all this hard work for no results--yet, that is. But hang in there. The following study of consensus interferon might offer some real encouragement:
<a href=http://www.projectsinknowledge.com/Init/G/1710/index.cfm#intro><b>Leevy et al: African American nonresponders re-treated with CIFN and ribavirin</b></a>
Carroll M. Leevy, MD, reported findings from a single-center, open-label trial of interferon alfacon-1 (consensus interferon or CIFN) plus ribavirin in peginterferon/ribavirin nonresponders. Consensus interferon is a genetically engineered molecule that has demonstrated greater biologic potency compared with the naturally occurring interferon alfas, such as interferon alfa-2a or alfa-2b.
The 137 patients enrolled in the study were separated into treatment groups according to race: African American, n = 45; Caucasian, n = 92. The groups were matched for genotype, viral load at baseline, viral load after peginterferon alfa-2b/ribavirin therapy but before consensus interferon, age, and gender. All patients failed to achieve early virologic response (EVR) after 12 weeks with peginterferon alfa-2b 1.5
Thank you all for your input. I am geno 1 in stage 3. But I haven't been checked since before my two treatments so I may be in stage 4. Someone at this site said he was stage 3 before treatment and in stage 4 after it was over. That scared me. I'm thinking about the nm283 trials. Maybe CIFN? Right now I'm looking for a good doctor in Chicago. I fired my last one because now I see that he should not have told me to go on two rounds of peg/ribaviron.
Dr. Leevy, being an African American himself, has done a lot of work in this area. Even though AA's do not respond quite as well as Caucasians, they also do not progress to cirrhosis as often as whites.
I would love to get the info on that. I'm pretty weak right now but as we all know, that can change any day, too. : ) I think dr. may rx procrit. Could you either put info here or e-mail it to me at ***@**** That would be great!
Many thanks and Smiles, Sue
Hey, thanks, Frank!
I checked that out and it sounds like fun!!
Hope to be able to make it. I'm in Wadena so it's a bit of a jaunt but if I'm doing better, I'd like to be there!
I get those two mixed up, too.
I have just been been told that I am a non responder. I have Hep C, type1. I had been on treatment for 13 weeks and it was not successful for me. I am feeling pretty down right now about it. I am African American and I do not really know what to feel this time. I have been feeling felt like I have been ill with the flu. I have not been on my zoloft either for about a week. I am feeling sad. I hope someone can give me some type of encouragment to keep me and all non responders pressin on. Where do non responders go now? HELP! HELP!!!!!
Hey Mocha! Glad you're still around. You can call me frank or scruffy or anything for that matter. Also, you can slip your questions into any of the posts up top or post a new one up top. Don't worry about making mistakes we have plenty of people who will tell you if you do! No sweat. Most of the people who come here are fairly new to the whole forum thing. I am well. I am a type 1a and treated with peg-intron/rebetol for 48 weeks. I tested clear athe end of tx(treatmeent) and relapsed shortly after stopping. I'm going in for a biopsy sept 8 and will determine what to do next.Post your questions about being a non-responder close to the current thread or start a new one and you will certainly get a response. Some of these people are quite knowledgeable. Take care, frank
Cutie-you little rascal! I knew some other wacko(with affection) would show up down here. Why we do who knows. See you. frank
Frank, thanks for answering. I am really new to the boards. I really do not know how they work yet, I am still in training. I am feeling better and feeling like a will continue on. I am going to be trying alternative medicine soon. How are you doing Frank?
Sandi!!!!!!! I get worried about you. I guess I should just get used to your irregular appearances huh? Glad you're ok and at least dropping by one of the 2 bottoms.(that sounds not quite right does'nt it?)LOL frank
frankdarlin, you're soooo sweet to be concerned. sometimes i just take a couple weeks off when things get crazy. i seem to get too much going on for my own britches, so don't get too concerned. i guess i'm kinda a stinker like that...but it's nice to know i'm cared about. thanks soooo much... tear tear...
you guys i hope you always know you are cared about and prayed for by me... always...even when i'm not online of course... i never stop thinking and caring about you all! i consider you my very dear friends and i'm sure we will always remain friends even after we all clear. i'm even talkin with bob about going to D.C. next year in hopes of meeting you guys...
(((CHEV))) i'm also trying to post some pics at msn FINALLY.
perhaps you WILL get to see your kitties after all...finally!
((("Honeypunkin and Dreamer"))) i have the cutest pictures of them having a play fight. they really are best buds! there all still so cute and complete characters...
i can't wait to show you. I have them in my computer now so if i don't get them to msn i will for sure email you copies. if that's ok that is.
hey where is Honey at these days has she been poping in at all?
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