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Beginning Incivik/Peg/Rib treatment
Starting treatment this week.  Is it better to begin first thing in the moring, or some other time of day?  And, how long after first injection do side effects occur?
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My treatment nurse said start the first day with your pills in the am, afternoon then take your shot about an hour or two before you go to bed, take pm incivek.  Side effects usually start in 3-4 hours

So start first thing in the morning...make sure you have calculated your pill times and set alarms!
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Is sleep effected with shot about an hour or two before bed?
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Most side effects are going to hit in the 6-8 hour range, so you will be asleep...everyone is different...I sleep like a log, but have major diarrhea in the morning.  
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I started with my peg injection on Friday afternoon (wanted to do it at the doctor's office since it had been a while since I had done an injection) and then started the incivek/riba that night. I was happy to have started on Friday as I slept much of the day Saturday and was a little more energetic on Sunday. At work today and tho I am counting down the hours I am doing OK. I definitely recommend starting on Friday or Saturday if you work during the week.
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PS I just started last Friday 1/13.
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I am on week 22, incivek done.

I take my RIBA at 5pm, I have found if I take it much later, I do not sleep well.

I take my shot Friday night at 9:00pm.  I have been up a couple times with body aches, Mostly i just get pretty tired within an hour or so and usually sleep through the night.  The first few weeks I did not.

Saturdays are usually ok, just tire out.  Pegasys actually takes 72 to 96 hours to reach it's maximum.  I find I start feeling worse Sunday and try to rest as much as possible.  Monday is my toughest days since I work.  Tuesday a close second.  

http://www.drugs.com/pro/pegasys.html

"Pharmacokinetics

Maximal serum concentrations (Cmax) and AUC increased in a nonlinear dose related manner following administration of 90 to 270 mcg of Pegasys. Maximal serum concentrations (Cmax) occur between 72 to 96 hours post-dose."
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