I started with my peg injection on Friday afternoon (wanted to do it at the doctor's office since it had been a while since I had done an injection) and then started the incivek/riba that night. I was happy to have started on Friday as I slept much of the day Saturday and was a little more energetic on Sunday. At work today and tho I am counting down the hours I am doing OK. I definitely recommend starting on Friday or Saturday if you work during the week.
I take my RIBA at 5pm, I have found if I take it much later, I do not sleep well.
I take my shot Friday night at 9:00pm. I have been up a couple times with body aches, Mostly i just get pretty tired within an hour or so and usually sleep through the night. The first few weeks I did not.
Saturdays are usually ok, just tire out. Pegasys actually takes 72 to 96 hours to reach it's maximum. I find I start feeling worse Sunday and try to rest as much as possible. Monday is my toughest days since I work. Tuesday a close second.
Maximal serum concentrations (Cmax) and AUC increased in a nonlinear dose related manner following administration of 90 to 270 mcg of Pegasys. Maximal serum concentrations (Cmax) occur between 72 to 96 hours post-dose."
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