Boceprevir Half Life

Does anyone got any idea how long it takes for BOC to leave the body,i know it take RIBA 6 months.I got a fuuny feeling googling this question will show nothing as the BOC is such a new drug.

[newleaf09]

My trial doc said riba left pretty quickly when I went in a week after EOT for a rash.  Sid it couldn't be the riba (and it wasn't).  When I was stopped for a few days, I began to feel better (hgb coming up) after about 4 days.  Interferon leaves fairly soon, too, after you miss the first shot but it has such a dramatic effect on systems that its effects can take 6 months to straighten out again.  Don't freak out about any lasting IFN effects till you get by the 6 mo. mark.

I agree with you that we probably won't get an idea about boceprevir remaining in the blood until it goes on the market.  Schering probably has a good idea but won't publish till later.  By then it won't matter to those of us who stopped the meds.

[Rockerforlife]

Merck took over Schring

[Rockerforlife]

A brief history of MDMA
MDMA [3,4-methylenedioxy-methamphetamine: 'Ecstasy'] was first1 synthesized in 1912 by the German pharmaceutical company Merck.


http://www.mdma.net/index.html

[Rockerforlife]

MDA was patented by drug company SmithKline French for use as a tranquilliser (1960) and appetite-inhibitor (1961). SmithKline were interested in MDA's potential as an antidepressant and a slimming-drug. In 1958 human trials were conducted; unfortunately the compound was to prove too psychedelic for licensed clinical use. But MDA was popular as "the love drug" in the counterculture of the 1960s.

[CoWriter]

"Does anyone got any idea how long it takes for BOC to leave the body"
-------------------------

It depends of what degree of hepatic impairment you have.

After ONE single 400mg dose of Boceprevir, for those with....

Mild hepatic impairment, half life was  5.04 hours.
Moderate hepatic impairment, half life was  4.77 hours.
Severe hepatic impairment, half life was  6.51 hours.

Co

Source:
http://www.hivandhepatitis.com/2007icr/easl/docs/041307_a.html

[Rockerforlife]

Looks like i am BOC free then,i know one thing,i can feel a big difference now ive stop the drugs...my mind is quicker and my muscles dont get tired,i was tired on the drugs and didnt even know because i so used to it...i just went for another montian bike ride as i was flying like a jet

[CoWriter]

Bear in mind that was for one single dose and it may be different after multiple doses.

Co

[CoWriter]

Rocker's right.  Ribavirin has a very long half life.


From "Ribavirin Official FDA information".....

"Ribavirin has a multiple dose half-life of 12 days, and it may persist in non-plasma compartments for as long as 6 months."

http://www.drugs.com/pro/ribavirin.html

Co

[Rockerforlife]

Im afraid to eat healty as i may detox the remaining TX drugs otta my body,i want them to linger as long as possible,at least 6 months,so no detoxing until then

[Rockerforlife]

BTW...i had one hell of a strange dream last nite,i dreamy the TX drugs made my neck one foot long when i looked in the mirror...i looked liked my alien profile picture.IT WAS SCARY

[newleaf09]

Thanks for link.  Redi-pens came with label, but riba was in a Schering bottle with no info.  Thanks very much for info!  I'm 7 wks post and still can't sleep, know it was the riba.  I'll stick with sleep aids for a while more.

Rocker, you've been clear a long time.  You had excellent compliance. You had few side effects but you still want the drugs to get the heck away from you now so you can get on with your life.  Let them go, the sooner the better.

[newleaf09]

I came across the mother lode for boceprevir info at this link:

http://www.hivandhepatitis.com/hep_c/hepc_news_alter.html

[Rockerforlife]

4 weeks of boceprevir treatment, SVR was 94 percent in the 48 week regimen (n=66) and 82 percent in the 28-week regimen (n=66). RVR has been shown to be a reliable predictor for achieving SVR

I just did 36 weeks and had a RVR in the above time frames,even tho im classified as a non responder,i think that the RVR trump card i have makes me a good chance to come out on top

[Rockerforlife]

Only negative thing i dont like is im 200 lbs and i couldnt get down to 180,im not obese,its just im a big guy and to lose 20 lbs i dont know where it would come off my body.it would have to my head