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Boceprevir

by JennyPenny2009, Nov 09, 2009 09:26AM
Does anyone know if the results in genotype 3 patients using boceprevir are approximately the same as those using telaprevir? Thanks.
Member Comments (15)

by Rockerforlife, Nov 09, 2009 09:41AM
From what i gather,no TX is being done on geno 2/3 with the protease inhibitors, but i do beleive trails are being done with the polmerase inhibitors on the geno 2/3.

by HopefulinScotland, Nov 10, 2009 05:50AM
Well, I know there has been at least some studies done on G 2/3 for telaprevir, because I've heard it doesn't work.

I'm looking for info on Boceprevir and Genotype 3, too. (BTW, I hate seeing 2 and 3 lumped together. They're very different in many ways and we 3's are often told stats that are skewed by the stats for genotype 2.)

by Marcia2202, Nov 10, 2009 06:09AM
So true... They have started not lumping them together. It is encouraging that they don't.

From what I remember is that g2 reacted fine to Tela, but g3 did not do well at all.

If I remember correctly, I don't think they have been doing any BOC trials for g3's, as it is too similar to Tela.

by HopefulinScotland, Nov 10, 2009 06:58AM
What I've heard is that there's nothing really on the horizon G3's. Meanwhile, we may have the fastest rate of fibrosis:

http://www.hivandhepatitis.com/hep_c/news/2009/102709_a.html


by newleaf09, Nov 10, 2009 07:29AM
http://www.hivandhepatitis.com/2009icr/easl/pdf/Preclinical_FNL.pdf is link to a poster from the very early trials.  They said it had activity against 3a.  I'll keep looking, but it seems that they targeted geno 1 once they got into the phase 2 and 3 trials.  Of course the major market is with geno 1's since it's the major geno in the US, but that does not mean it is not effective against other geno's.  The trials just haven't concentrated on them.  Look back at the earliest studies, most of which are reported on hivandhepatitis.com in the experimental drugs section.

by Rockerforlife, Nov 10, 2009 07:35AM
Geno 2,errr 3  has a 80% cure i think,so this is another reason why the compainies are concentrating on the geno 1`s

by HopefulinScotland, Nov 10, 2009 08:24AM
No, Rocker... Genotype 3 does NOT have a 80% rate of SVR with the current standard treatment. It's more like 60-65%.

Lumping the two genotypes together has confused a lot of people... Genotype 2 is much more responsive to tx than genotype 3.

Newleaf, I am encouraged to hear this! I know that Teleprevir has been found pretty much useless for genotype 3 and it would be nice to learn that there could be better success with Boceprevir.

I am about to start tx in January and I will feel better knowing there could be a fall-back in case I don't achieve SVR. :)

by Rockerforlife, Nov 10, 2009 09:26AM
To: HopefulinScotland
Just curious,do you have study papers that state geno 3 is only 60-65% cure rate,maybe geno 2 has the 80-85% rate.Il try to find the trial paper again

by HopefulinScotland, Nov 10, 2009 09:36AM
To: Rockerforlife
Not one particular study - those are just the numbers I've seen in a lot of places. I'm not so sure about the SVR rate for G2, as I'm primarily concerned about G3. :)

Here's a pertinent article:

http://www.hepctrust.org.uk/news/2008/April/EASL+HCV+Genotype+2+And+3+Respond+Differently+To+Anti+HCV+Treatment.htm

by BelB64, Nov 10, 2009 10:48AM
To: hopefulinscotland
There are actually many drugs that will be effective against genotype 3. Right now Pharmasset's polymerase inhibitor R7128 is VERY effective against geno's 2 and 3 in similar numbers. 90% of geno 2's and 3's of non responders achieved RVR after 4 weeks with SOC.

Avila has a new drug AVL-181 it's testing that's a small molecule protease inhibitor that's "demonstrated inhibition across multiple genotypes"

Many other trials are beginning with drugs that are effective across all genotypes. Even though Geno 1 is the dominant genotype 20% -30% of the world's HCV population is genotype 2 and 3 which translates to tens of millions of potential patients. This is why any drugs that are effective against all genotypes will be the ones to potentially make the most money.

by HopefulinScotland, Nov 10, 2009 10:56AM
To: BelB64
It's nice to hear that!

by RCM829, Nov 10, 2009 11:16AM
To: HopefulinScotland
Yes, Belb64 is correct.

In addition to R7128 (which is the front runner), there are several drugs  in the pipeline that currently appear to be very effective for us geno 3's.

One of my doctors - a prominent liver transplant doctor in California - told me these drugs are still at least 3 to 5 years away from FDA approval however.

Good luck with your treatment!

by jessiejames1973, Nov 11, 2009 11:47AM
r7128
could be ten years away

by Bali05, Nov 11, 2009 11:52AM
To: all
could not agree more .
lumping genos together *****.

anybody know anything referring to geno 4 and the new drugs?

by Rockerforlife, Nov 11, 2009 12:04PM
To: HopefulinScotland
SVR was significantly lower in HCV G3 (80%) than in HCV G2 (94%; p 0.002).

I read this in your post,so wasnt my statement correct?...
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