Food effect: The bioavailability of a single oral 600 mg dose Copegus was increased by coadministration of a high fat meal. The ribavirin exposure parameters of AUC(0-192h) and Cmax increased by 42 % and 66 %, respectively, when Copegus was taken with a high fat breakfast compared to being taken in the fasted state. In order to achieve optimal ribavirin plasma concentrations, it is recommended to take ribavirin with food.
In addition it helps to avoid gastrointestinal side effects compared to being taken in the fasted state.
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