Daclastavir vs Ledispivir?

[penn1023]

When I start treatment this year or next and if I have a choice I want the best combo possible for me. Does anyone here know the stats of Sovaldi and dac vs led? Which one has the better results of the two in combo with Sovaldi? Which one has the least sides of the two? I am 1b, stage 1-2 grade 1 in 2011 very high VL.
Thanks

[nan535]

."He has been getting moody again and like he was before he started treatment.i swear this virus is causing that too. "

So sorry that you received confirmation that the virus is back. At least you don't have any doubt a lab error was made and can start planning your next steps.  I am happy to hear he is going to see a new doctor that specializes in Hep C. This is not to say your doctor did anything wrong. The Hep C virus is a formidable enemy and it's time to pull out all the stops and go with the best in the field.  As for his moodiness, yes, without a doubt, I agree that it is all related to this virus and it's impact on his body. My husband experienced much moodiness before and during treatment.  He has been even tempered since completing treatment (4 weeks ago). Waiting now to find out results of his 4 week post treatment HCV test.  His other lab results continue to show good improvement so we're hoping that bodes well for a positive outcome.

Hang in there.  His day to be Hep C free will come.
Nan

[dragonars]

Was informed last week that I relasped sovaldi/ribb g2b. This is my second tx failure. Bones said theirs better stuff coming. Have an appt early dec to try again. Maybe third time is charm.

[nan535]

"He has been getting moody again and like he was before he started treatment.i swear this virus is causing that too. "

[Faithdove]

Hi hepcamdme, you relapsed in S/O?
He felt horrible during treatment and his liver enzymes never truly came down to the normal range during treatment. Now he is depressed and thinks this is going to kill him. We had the test rerun and it is definitely back. He has been getting moody again and like he was before he started treatment.i swear this virus is causing that too. We will be seeing a new doctor as his current doc, gastro, feels it would be best for him to see this specialist (for Hepc).

[Sarah1949]

Actually, it's a simple decision. Ledipasvir/sofosbuvir will be here in a little over a month.
Daclatasvir will probably be awhile.
Both are more than I ever hoped for in my lifetime.

[hepcandme]

Damn! Faith, that is too bad. How does your husband feel? When I relapsed on S/O, I just didn't feel well like others who had achieved SVR

I am really hoping that his labs were wrong but if *** turns out that he relapsed, the good news is that your husband will have less of a trial when the new drugs come out

[penn1023]

My appt. is Nov 3 so I will just have to trust my doc

[Faithdove]

Gilead should get more heat for not working with Bristol Myers to get the Sovaldi and Daclatasvir clinical trials. If that is the case and if like you said, it could have been out in Dec. 2013 for people. My husband just went through the hell of Sovaldi with the Ribravain and interferon only to now be positive again at EOT 12 weeks. Hei is genotype 1a.  I am going to ask his doctor to have his Test rerun just because we are still in shock. I am praying it was a lab error.

[dointime]

I don't think it is possible to get the answer you are seeking for this question because, as others have said, the dac. combo has not been put through the same thorough testing regime as the led. combo.

That being said, I would personally go with the dac. combo which showed exceptional promise in the trials that have been done with it.  However, that combo is not approved and not readily available so I'll probably have to go with the led. combo and hope that there's not much of a difference.

dointime  

[patra_]

Led studies are mainly w/Gt 1s and 2s.

Dac did/is doing studies w/Gt 3s.  I Believe ai read that it was New Zealand doing the studies as Gt 3 is more predominant in that part of the world.

I also believe studies are being done in the US Dac/Sol, but so far, have not found a site telling me that.  Even though I just completed Week 9 (this a.m.), I am still trying to follow these trials in case the Sol/ Riba doesn't get me to SVR, since I am Gt3.

Has anyone seen any current studies on this?  Pat

[48weeks]

I think everyone is saying they're very similar, and Ledipasvir is scheduled to be realeased in October, I haven't heard when Dac will be released. Also Dac and Sofusbuvir are made by two different companies so this off label situation probably won't be approved unless Ledipasvir doesn't get approved.

[penn1023]

Still, which is better with Sovaldi, according to reports, Dac or Led?

[penn1023]

They took samples from two parts of the liver back then. I guess I just have to try to go with the flow.  Let my doctor advocate for me or I'll go nuts.

[hoping4cure]

Susan's correct, Gilead took a lot of heat for discontinuing clinical trails using dac with sovaldi because it would have come to market probably in December of last year. They pulled out and decided to develop their own NS5 drug which was ledispasvir.

You should have an ultrasound or CT with contrast plus a fibroscan done to see what your current status is. If you had a biopsy back in 2011 they could have hit a good spot where there was little damage. I was told that biopsy's give false readings 30% of the time.

[penn1023]

Hi
I treated with IFN in the 90's and it caused all kinds of autoimmune problems which I still have. Maybe they will let me have it without IFN because my hep doc says I am IFN intolerant and it would kill me to have IFN again. Plus I was a non-responder

[flyinlynn]

Hi Susan

Science stuff follows:

Daclatasvir: the first of a new class of drugs targeted against hepatitis C virus NS5A.

http://www.ncbi.nlm.nih.gov/pubmed/24372205

Ledipasvir is an inhibitor of the hepatitis C virus NS5A protein.

The ledipasvir/sofosbuvir combination is a direct-acting antiviral agent that interferes with HCV replication and can be used to treat patients with genotypes 1a or 1b without PEG-interferon.

http://en.wikipedia.org/wiki/Ledipasvir

so they do appear to be similar in action

Lynn

[susan400]

Are they in the same class of drug? I'm not familiar with either one, yet...  I know that they are new drugs that are coming out.  I mean like for example:  Telaprevir and Boceprevir (Same class of drug);    Pegasys and Pegintron (Same Class of drug).  I am not sure but are they a new generation of a protease inhibitor?  Maybe one of these experts can weigh in.  I can't advise you either way since I don't know anything about either one.  I've treated 11 times (this is #11), but never with these 2 new drugs that will be coming out.  I am currently on Sovaldi and Pegasys and Ribavirin.  Susan400

[bluemetal]

As a gt 1b F-1-2 non-cirrhotic, it doesnt matter. Either drug is highly likely to destroy the virus withn 8-12 weeks, that is acheive SVR 8-12. You have the luxury of a worry-free life starting right now. The only problem I foresee is insurance obstical. Since your not F-4 (cirrhotic), its highly unlikely they will even consider approving you for any all-oral tx. My guess is theyll offer Sovaldi with Peg or Riba, two very brutal drugs straight out of hells own factory. The new gen drugs are being reserved for cirrhotics unless something in the political arena changes between now and autumn.