Here is just one of the many dangers of ALA IV therapy:
This is from Pubmed which is considered to be very trustworthy by the medical community.
"We conclude that large doses of lipoic acid displace sulfhydryls from binding sites, resulting in depletion of serum cysteine, but also pose a methylation burden with severe depletion of liver S-adenosylmethionine and massive release of S-adenosylhomocysteine. These changes may have previously unrecognized deleterious (harmful) effects that should be investigated in both human disease and experimental models"
so, in other words, if we drink a quart of oil a day it will make us sick ??
who is going to do that? who finaces these studies and why is what I wonder!!
you might as well add what protein overload, or oxygen overload, or severe weather exposure will do to people. Every severe exposure does harm.
the truth is essential fatty acids are crucial to good health.
they exist in most of the foods we eat, they are so crucial the liver MAKES them even when we don't eat them, because without them we die.
essential fatty acid prevent oxidation, a chief culprit in both inflammation, fibrosis, and HCC....let's look at the pub med proofs there as well.
do people need IV's of the stuff...no....they don't, that I think may be if not a scam, at least taking advantage of folks not knowing the chemistry or the science....
you can change your profile through diet very easily. I increase my HDL 40 pt's in only 2 months...just by minor changes to diet and a supplement.
I'm getting really tired of studies where they give rats 100 to 1000 times more of something than would be normally found....and then pronounce the substance as evil.
I'm very suspicious of who is behind these type aberant studies...yes, we do need to know when something becomes toxic, but we cannot conclude that an overdose makes a therapeutic level bad...that is faulty logic.
Which things can you name that would not produce reactions if 100 times more was taken than normal?
Even air and water aren't safe in such cases. If you took 100 times more water everyday than you need you will die, likewise with oxygen same thing...dead....by this standard then, the ALA is pretty safe, even overdosed to the max it doesn't kill you like most things would!!
also note 1st paragraph, essential to life, you die without it...your gut and liver make it...
also note 309 studies follow this exegesis
309 medical studies...we report, you decide.
I can tell you this, I eat oatmeal for breakfast, sardines for a snack (many foods contain lipoic acids but because I am trying to keep my iron rich food consumption down, I choose to take a supplement and to choose foods rich in lipoic acid but not as high in iron (meat and broccoili are good but high iron.)
the supplement means I could increase my HDL profile without extra iron.
results=HDL rose nicely, LDL remained close to the same, overall profile is more hdl than ldl and low triglycerides now, before, not so.
other benefit= my neuropathy has reversed...I am no longer having the pins and needles or sharp stuck with a pin or dull deep aches I was having in my feet.
In fact, no hand pain the last couple months....very surprising.
my blood sugars are normal again, I have no need of type 2 meds so have discontinued them..
my seizures are much better than before and I am able to sleep again without the dopamine antagonist requip. Actually doing better without it since adding the ALA than I was doing with the requip and no ALA....(and no headaches like the requip gave me...so this really does settle down nerves, I can see why the MS community has come fully into this court.
all these corrections were well documented 50 years ago by Linus Pauling, Nobel Prize winner for his research into nutritional components.
they have been restudies and reconfirmed by researchers all over the world...
thank goodness people can pull up all the studies themselves and not rely on one or 2 abberant studies.
ALA is extensively used now by the diebetic and MS community because it is known to sooth nerves, reduce neuropathy, increase normal metabolic rate, reduce insulin resistance, and on and on. Lately it is receiving even more press for it's role as an antioxidant and possible benefits to liver patients in need of oxidative relief although it will be a while before we know for certain it's role here it appears to not compromise methalation unless overdosed form what I've seen and read.
The truth is, most anything will mess with methalation if you eat enough.
HR, medical doctor, tried to warn us about eating small amounts more often...not sure who took that advice but it's true, a compromised liver can't take as much or anything....so a word to the wise here.
Another essential known as PPC is also showing much promise in this area of oxidation relief as well as fibrosis reversal. If you stop to think about it it makes sense...abberant cells leads to more fibrosis, the sooner a cell goes rouge the sooner it causes distorted growth and scarring around it...
Obviously 309 studies is just the tip of the iceberg, but it is clear that oils do effect oxidation.
Anyone who owns a cast iron skillet knows how this works.
If you wash your pan, and leave it unoiled it will oxidize and start turning the tell tale red immediately, but if you season it with a little oil rubbed on, it will not oxidize.
Since oxygen interacts with stored iron in the liver, the idea is to keep oxidation low, as oxidation produced free radicals which are the precursors to cancer. The more free radicals formed, the more likely one will succumb to liver cancer. The free radical is what causes the cell to mutate into a cancer cell. Oxygen causes free radicals...we need it to breathe and live, but too much is deleterious.
Liver cancer is the 7th largest killer in the USA.
Ergo, low iron and good fats offer protection against the dreaded HCC to which 3-5 people reading this, out of every hundred reading, will succumb this year.
Since so much information exists as to the benefit, and only a spare few studies using overdosing exist to the contrary, I leave it to the reader to decide whether an ounce of prevention might be worth a pound of cure here.
BTW, liver cancer is almost never survived, it is a rapidly spreading almost always fatal condition so this might be something to think through in advance. If you have HCV you are at a much higher risk for liver cancer, higher than the 1 in 7 rate that exists in the general populace.
In fact at the HCV rate of 3-5% per annum that means in 10 years between 25% and 50% of us reading this will have developed HCCancer. That's scary stuff.
As merrybe said, lipoic acid is an endogenous substance, meaning it is made by the body. It is essential to life. The liver is packed with it when we are young; our bodies make less of it as we grow older.
Lately you have been touting vitamin d on the board, which I approve of. As with lipoic acid, there is tons of evidence showing its therapeutic value. What would happen if you took a 20-40 X dose? It's called vitamin d toxicity. Same with vitamin a. Does that mean you shouldn't take safe doses of those vitamins?
What would a 20-40 X dose of INF/riba do to you? Obvious damage. Does that mean you shouldn't take the prescribed dose?
I will say it again. I do believe in supplements INCLUDING Alpha Lipoic Acid. I do NOT believe in it with IV use, especially with the expensive way treating with berkson. I think it is a scam and dangerous. I feel he is taking advantage of people with serious illness who have no where else to turn.
If there was any validity in berkson's claims it would be FDA approved and covered by insurance !!!
Many studies done and still no FDA approval, what does that tell you............It tells me that although there have been some promising results NOTHING have been proven !!!
That is all I have to say on this subject. I will continue to post the dangers of "IV" ALA use.
You said, "If there was any validity in berkson's claims it would be FDA approved and covered by insurance !!!"
FYI, the FDA only approves drugs. Alpha lipoic acid is not a drug, therefore it is not possible for the FDA to approve even it even if it wanted to. The FDA does not approve apples either, that does not prove they are unsafe.
Insurance does not cover many therapies, including many standard therapies that it simply does not want to cover, for instance, pre-existing conditions. Insurance coverage does not validate or invalidate any therapies. It has nothing to do with validity.
You also said, "This is from Pubmed which is considered to be very trustworthy by the medical community." and "I will believe peer reviewed pubmed articles...
Here are two pubmed articles authored by Dr. Berkson, who happens to be the FDA lead investigator of lipoic acid:
Both cases involve intravenous administration of alpha lipoic acid in combination with the oral administration of Low Dose Naltrexone. While these cases involve pancreatic cancer, and not hepatitis c, they certainly do involve the IV administration of alpha lipoic acid, which you claim is unsafe. Additionally, there are a great many examples of studies involving the IV administration of alpha lipoic acid on pubmed with very positive outcomes, including Insulin Resistance, Diabetic Neuropathies, etc, etc.
I am looking forward to see more of the pubmed articles that you claim validate your theories.
By the way, the two articles authored by Dr. Berkson above involve the intravenous administration of Alpha Lipoic Acid and the oral administration of Low Dose Naltrexone. This is exactly the same protocol that he uses for his hepatitis c patients. Therefore, if we are talking strictly about the safety of the protocol, these two articles are relevant to the conversation.
yes, I also heard of the pancreatic reversals...I wonder if that's what they gave to that woman who does the Cancer Center's of America commercial...she had pancreatic cancer...
don't know....I do know like anything we don't want to overshoot on this or any med, natural or synthetic....which is why I got my blood work 2 months ago, and will again this week...I don't want to overshoot...if my number is still rising I will dial back my dose.
however, I think the oxidation is a bigger issue than many folks think.
In fact some geologists say the reason people lived so long (if you believe the biblical ages assigned to the patriarchs) is because the oxygen levels were different pre-flood....it's also impossible for the dinosaurs to have reached their sizes in our current atmospheric pressures....so the theory goes that something striped a lot of the atmosphere away, an asteroid maybe one that hit, or a passer by, who knows....one in Russia and another on the Yuccatan...we weren't here so who knows...but this event changing atmosphere, shifting the continents etc...changing composition and pressures etc.
how does this tie in to alpha lipoic???
the way I see it is that radiation and oxidation are the 2 largest producers of free radicals which degrade cells turning them into malignant monsters.......so if the ozone and other layers were much thicker...people would have lived a lot longer because without the forces that destroy and break down cellular structure there's no telling how long things could survive, we do have repairative features built into each cell....so....in a different atmosphere both plants and animals would have been much bigger...which the geology (and the bible as well) attest to having been the case, huge people and huge creatures....they also could have lived far longer.
maybe seeing rats live much longer is a hint here...rat metabolism is surprising close to human metabolism...why do they live so much longer when this item is added???.
In any event, if we return to diets higher in HDL essential fatty acids we will see some benefits because these allow us to absorb oxygen yet protect against it's damaging effects.
I'm glad to see everyone basically agreeing that some supplementation here may be wisdom....we can wonder whether every doctor out there is on the up and up...but the bottom line is not to throw out the baby with the bath water!!!
SVR Improves Survival, Risk for Liver Cancer, Decompensated Liver Disease and Liver Transplant/Death - Also, Transient Viral Suppression (breakthroughs/relapsers) Improves Clinical Outcomes Too
Reported by Jules Levin
AASLD Oct 31-Nov 3 209, Boston, MA
The main outcome of this study is that SVR reduces risk for HCC, decompensation, liver transplant/liver death any other clinical outcomes compared in the HALT-C Study, which looked at peg/rbv nonresponders and included patients with advanced disease. This is good because some federal government committees have suggested there is not adequate proof that SVR improves clinical outcomes for patients and therefore have not supported federal funding for programs for patients including HCV screening and surveillance and therapy as well.
Although the main outcome of this study was that that SVR reduces cancer, death, clinical outcomes, decompensation.....However......As we know patients included in the HALT-C study had advanced liver disease. Two years ago the HALT-C investigators reported at AASLD that maintenance therapy did NOT provide clinical benefit. These headlines made quite a splash and many clinicians stopped using maintenance therapy as patients & clinicians presumed it had no benefit. Several months later at EASL in April HALT-C investigators presented that if patients had a 4-log viral load reduction there appeared to be some benefit. Now at this AASLD last week the same investigators reported patients in HALT-C who were breakthroughs/relapsers, "patients with viral suppression", had significantly reduced risk of developing any liver-related complication when compared with non-responders; see graphs and table below: reduced risk for "any outcome, decompensation liver transplant/liver death" appear statistically significant, reduced risk for HCC was not statistically significant between nonresponder and breakthrough/relapser but there appeared to be a reduced risk in the number of events.
By the way the HALT-C researchers have refused to share slides after their presentations so they can publish their results. They refused to share the slides 2 years ago after they presented at AASLD that maintenance therapy was NOT beneficial. If the original design of their study inquiries had been better designed to include looking at partial responders we would have had better results 2 years ago and better understood how to use maintenance therapy.
"In fact at the HCV rate of 3-5% per annum that means in 10 years between 25% and 50% of us reading this will have developed HCCancer. That's scary stuff.
How many hunderds of HepC folks are on ths board? How many diagnosises of HCC have we seen in our little cluster of miscreants? The numbers don't add up."
At a new-diagnosis rate of 3-5% a year, the projected rate in 10 years wouldn't be 25-50%, it's be less than 1/20th of the 3-5%, and of course, that rate would also be per annum. No need to be scaryDad ;).
On the flip side, in our little cluster, I'm personally aware of 4 diagnosis of hcc within our current membership. Sadly, the majority of the hcv-hcc diagnosed individuals probably wouldn't be here, as one-year mortality rates post-diagnosis of hcc is close to 90%.
... are there any large-cohort studies, retrospective or otherwise, of standard dose (oral or IV administration) of ALA as it impacts the hcv/hcc population?
The above should have said:
"At a new-diagnosis rate of 3-5% a year, the projected rate in 10 years wouldn't be 25-50%, it's be less than 1 in 20 of the 3-5% to develop cirrhosis, and of course, that rate would also be per annum with hcc incidence in the lifetime of that 3-5% population being less than 1 in 400."
Digestion Related Problems
One of the very common side effect of alpha lipoic acid is, problems related to digestion. It leads to problem like nausea, upset stomach, stomach ache and constipation.
Sugar Level Problems
It is also known to decrease the sugar level to a large extent. This can be beneficial to diabetic patients but, it might pose a problem to healthy individuals as extremely low sugar level is not recommended for them. You may also like to know more on diabetes blood sugar level.
Skin Related Problems
Lipoic acid can also gives rise to skin hives and itching skin will be also observed in very rare cases. Also, excessive sweating is observed in people suffering from alpha lipoic acid side effects.
Respiratory problems are also observed commonly as a result of alpha lipoic acid side effects. Problems like difficulty in breathing, tightness in chest and increase or decrease in the pulse rate are the most common problems associated with it.
Cold Related Problems
There are chances of some people suffering from common cold, cough and runny nose. In some cases, all these disorders might also be accompanied by fever. The person may experience headache as well.
Other Side Effects
Apart from the above mentioned problems, fatigue, insomnia and over stimulation are also observed commonly. Some people might experience tingling sensation in the whole body, muscle cramps, and swelling of the face and extremities. Flatulence is also one of the side effect of alpha lipoic acid.
Consume alpha lipoic acid but, make sure that you consume in the right amount to stay away from alpha lipoic acid side effects. It should be present in the body in optimum amount, else it can cause brain related problems like stroke, Alzheimer's and Prrkinson's disease. If you realize that you are suffering from alpha lipoic acid side effects, visit a doctor without any delay.
Side effects of alpha lipoic acid may include headache, tingling or a "pins and needles" sensation, skin rash, or muscle cramps.
There have been a few reports in Japan of a rare condition called insulin autoimmune syndrome in people using alpha lipoic acid. The condition causes hypoglycemia and antibodies directed against the body's own insulin without previous insulin therapy.
The safety of alpha lipoic acid in pregnant or nursing women, children, or people with kidney or liver disease is unknown.
Possible Drug Interactions
Alpha lipoic acid may improve blood sugar control, so people with diabetes who are taking medication to lower blood sugar, such as metformin (Glucophage), glyburide (DiaBeta, Glynase), should only take alpha lipoic acid under the supervision of a qualified health professional and have their blood sugar levels carefully monitored.
Animal studies indicate that alpha lipoic acid may alter thyroid hormone levels, so it could theoretically have the same effect in humans. People taking thyroid medications such as levothyroxine should be monitored by their healthcare provider.
It has been well established that hepatitis c increases oxidation and decreases systemic antioxidant levels. Hep c increases the generation of ROS (reactive oxygen species) which cause much of the damage.
From the above link:
"Infection with hepatitis C is associated with increased levels of ROS/RNS and decreased antioxidant levels."
Increased oxidation also plays a role in HCC:
"Most hepatocellular carcinomas occur in cirrhotic livers, and the common mechanism for hepatocarcinogenesis is chronic inflammation associated with severe oxidative stress..."
also, ROS (reactive oxygen species) generated by hep c play a large role in the increase of fibrosis:
"ROS/RNS can activate hepatic stellate cells, which are characterized by the enhanced production of extracellular matrix and accelerated proliferation. Cross-talk between parenchymal and nonparenchymal cells is one of the most important events in liver injury and fibrogenesis; ROS play an important role in fibrogenesis throughout increasing platelet-derived growth factor."
ALA is a master antioxidant. It is both water soluble and fat (lipid) soluble. It is also a precursor of glutathione, our best intracellular antioxidant and the linchpin of our body's antioxidant system. Glutathione recharges our water-soluble antioxidants (vitamin c) and our lipid soluble antioxidants (vitamin e). Lipid soluble antioxidants are at a premium for us because lipid peroxidation is a main culprit in the pathogenesis of the disease, as well as the generation of HCC.
For all of these reasons, ALA is one of the best weapons in our warchest against hep c damage. We need more antioxidants than healthy people, and ALA is one of the best antioxidants available to us.
Copyman is correct to warn about the use of ALA by diabetics on insulin. ALA is well known to decrease Insulin Resistance; therefore, if a diabetic is on insulin and takes ALA, his blood sugar levels should be closely monitored, and a reduction of the amounts of insulin you take might be necessary.
Think about this, one of the various meanings of "objective"
3 a : expressing or dealing with facts or conditions as perceived without distortion by personal feelings, prejudices, or interpretations.
Every time I read such threads I am perpetually assaulted by posts which fall victim to all of these shortcomings.
This thread starts out with the apparent attempt to misinform. It calls the use of ALA as dangerous, but fails to make note that one has to OD on the substance for it to become dangerous. One also fails to hold forth the "solution" .....SOC...... to remotely the same standards by which one wants ALA judged.
I don't know the answer, but this is not an "objective" inquiry or warning. Rather it is an attempt to prove ones view using whatever means one can. I read these threads and think; this is why doctors tell patients to stay off of the internet.
I know that people mean well, but laymen arguing either way as though they can prove or disprove efficacy is kind of naive, IMHO.
I'm in favor of allowing such threads as long as over the top unsubstantiated claims are not made. It seems to me that Bali and Mike H have had reasonable results with their use of these types of adjuncts. Possibly, if there are negatives with treating this way there should be evidence of it on the internet. Equally certain, there are more than a few anecdotal accounts of bad responses to IFN-RBV therapy.
I think that to some extent, this is a tempest in a teapot. Relatively few will treat with IV ALA. In a few years relatively few people will do SOC; it will all be triple or quadruple drug therapy, or..... possibly.... *merely* 2 stat C drugs w/o IFN-RBV.
At that point, no one will care a whit about the therapy that at MedHelp anyway, has a few with their knickers in a twist. ; )
Carry on, carrying on. : )
PS....it seems to me incorrect thinking to assert that a compound or drug given by pill becomes a scam when administered by IV. I believe that there are many type treatments which require the use of an IV. It can either be to administer vit B-12, or iron for instance instead of relying on slowly giving people pills. I am under the impression that NAC is given to Tylenol OD victims as well. One can increase the dosing, sidestep the digestive process and also net faster results that through the use of pills administered orally. IV administered ALA is also likely of better quality or purity that the cr@p that one may buy at the 5 and dime. Doing it under a doctors care may be safer than treating as some of us do; reading the internet, making a *buy* at the Walmart and treating ourselves. : )
I would also point out that oral administration of ALA is quite beneficial; it is easily absorbable and it is important, in my opinion to take the pills morning and night. No one can continually do IVs, and sporadic IV administration is not as good as continual oral administration. However, occasional IVs in conjunction with oral administration gives greatly increased benefits, also IMHO.
The notion that IV administration is dangerous per se can be easily contradicted by a stroll through any hospital or ER. The number of people hooked up to an IV bag usually greatly outnumber those who are not. I see no difference in a doctor giving you an IV in the hospital as opposed to his clinic. Also, these IVs are often not as expensive as some would lead you to believe. That being said, many cannot afford any out-of-pocket expense, and for those people, sadly, even oral administration may be a financial burden.
Vitamin E is good. Apparently, Vitamin E is not and resveratrol has recently come under suspicion for aiding in the replication of the virus.
Vitamin D is good. Green tea extract and curcumin are good, milk thistle inhibits the replication of the virus.
Vitamin A is depleted in hep c as is beta-carotene, so it might be wise to supplement those. Also Activated stellate cells, which are associated with fibrogenesis, actually store vitamin a and their depletion may have deleterious effects on the process of fibrosis:
Basically, a diet rich in fruits and vegetables provides high levels of polyphenols, all of which are antioxidants.
Common sense would suggest not overinduliging in anything, even that which is good for you.
Too much of anything isn't good for you. Don't eat and you die. Eat too much and you become obese. You can eat yourself to death.
All things in moderation isn't a bad credo.
But the very best thing is to eat healthily, get some exercise and reduce stress.
Coming here, I hear groups of people trying to grasp a brass ring that is on a different carousel for each one.
Our bodies are different and HCV affects us differently, which makes it all the more frustrating.
I agree. I believe that diet is more important than supplementation. Plus, the benefits of supplementation might be easily voided by bad diet. However, as merrybe pointed out, lipid peroxidation, or oxidation of fats, is a key to hep c pathogenesis. Most food-based polyphenols are water soluble, with rare exceptions. Since Vitamin E, which is generally regarded as the most prevalent lipid-soluble antioxidant, has been taken off the table, that makes alpha lipoic acid that much more valuable as one of the only lipid-soluble antioxidants left (besides vitamins a and d).
also be per annum with hcc incidence in the lifetime of that 3-5% population being less than 1 in 400."
I just watched yet another friend of mine who had HepC (she didn't treat because she didn't want to lose her hair) - this is the third person I've known with HCV who developed HCC and died of it because they thought treatment was worth than the disease could be until it was too late. These are personal friends - not a group off the internet but people I've known for many years. Two women one man but all about the same age (45 - 50).
Believe me, it makes me more serious about truly eradicating the disease than anything and unless it was proven without a shadow of a doubt that these meds would work...........its just not worth it. No sir not one little bit - it's just too horrendous a death to play with.
Sorry, in my post to Bill above there is a typo in the first sentence that is misleading. It should read that Vitamin C, not E is good. Apparently Vitamin E is bad in that it aids in hep c viral replication.
I am so sorry to hear about your friend. How sad that fears (maybe unfounded) about potential treatment side effects kept her from saving her own life.
Sure, interferon and ribavarin can cause some very unpleasant side effects, but for people like us there really is nothing else to do except gather up our courage and fight this horrible disease. Every time I hear of a life lost to this plague it breaks my heart. Losing your hair (temporarily) or any other side effect from treatment is nothing compared to losing your life.
Apparently Vitamin E is bad in that it aids in hep c viral replication. ??????
where did you see this?..VIT E is in a lot of foods,like nuts and seeds,especially sunflower seeds...
Damaged liver tissue is depleted of antioxidants, not just vitamin E, but also beta-carotene, vitamin C, and lycopene. Taking these antioxidants helps toxin-damaged liver tissue recover. If they are taken soon enough, they may even prevent toxin damage from occurring.
You are linking a story from an Internet vitamin sales website. That is not even close to a clinical study. That is the reason that these things should proven scientifically. It also points out that there is dangers in making assumptions. As far as I know, there are no clinical trials on ALA that show any benefit. Dr b claims to to be a former FDA principal investigator of ALA and yet there is not one peer reviewed paper on ALA and HCV. How come?
"...there is not one peer reviewed paper on ALA and HCV...."
http://www.ncbi.nlm.nih.gov/pubmed/16082287 - this study included ALA as one of the tested nutrients from the peer-reviewed journal J Clin Gastroenterol. 2005 Sep;39(8):737-42
"CONCLUSIONS: These data suggest that multi antioxidative treatment in chronic HCV patients is well tolerated and may have a beneficial effect on necro-inflammatory variables. A combination of antiviral and antioxidative therapies may enhance the overall response rate of these patients."
A 1999 paper Berkson authored, before he added Low Dose Naltrexone to his protocol:
"The triple antioxidant combination of alpha-lipoic acid, silymarin and selenium was chosen for a conservative treatment of hepatitis C because these substances protect the liver from free radical damage, increase the levels of other fundamental antioxidants, and interfere with viral proliferation. The 3 patients presented in this paper followed the triple antioxidant program and recovered quickly and their laboratory values remarkably improved. Furthermore, liver transplantation was avoided and the patients are back at work, carrying out their normal activities, and feeling healthy."
The lack of clinical trials reflect the lack of funding. Since neither Alpha Lipoic Acid or Low Dose Naltrexone are proprietary (the patent ran out on LDN, and is now in the public domain), no special interests exist that are willing to invest the large amounts of cash necessary to conduct clinical trials. Most clinical trials are funded by drugs companies with proprietary interests - these funds are re-couped because they own the patents and therefore benefit from the resulting therapies. The purported mission of the FDA and NIH is to fund investigations into promising novel therapies, but they rarely conduct trials that are not in the interests of the drug companies. And the ALA and LDN therapies are most definitely not in the interests of the drug companies.
"I might add, there are no clinical trials that show lack of benefit either."
The burden of proof is on the one that makes unsubstantiated claim, not the other way around.
"Dr. Berkson can hardly be blamed for not funding hugely expensive clinical trials. He certainly has been urging that that should happen."
He should provide proof of his theory before taking $1,000s from people.
I did a little digging on his 1999 paper which btw was not peer reviewed. He claimed that the 3 patients avoided a transplant within a year of therapy. There was no reason that they should need a transplant because they were healthy and their platelets were twice as high as mine before he treated them. I had a professor that used to say long on words and short on facts.
NIH grants studies all of the time thing that show promise. What exactly does a ala principal investigator do for the FDA?
ALA is highly concentrated in certain plant oils such as flaxseed oil and to a lesser extent, canola, soy, perilla, and walnut oils. ALA is also found in wild plants such as purslane. Once ingested, the body converts ALA to EPA and DHA, the two types of omega-3 fatty acids more readily used by the body.
Looks like im gettn my ALA again from flax seeds because i eat a 1/4 cup of them ground up with my whey shake
Dr. Berkson has been pretty open about reporting the case histories of his patients. Those are hardly unsubstantiated claims. If you don't believe him, then don't use him. If you don't believe that the FDA appointed him as the lead investigator of lipoic acid, that is your prerogative. If you believe that the moon landing was a hoax, more power to you. I know you are on tx; I hope that works for you. I doubt somehow that you have genuine interest in any other therapy.
You asked for a clinical trial involving ALA and Hep C. I gave you one. Not satisfied, you go off topic, and attack Dr. Berkson personally, like so many others on this board. What about the use of ALA for Hep C patients? What does your dislike of Dr. Berkson have to do with that topic? And who does it serve?
Clinical trials are often the result of doctors and patients using novel therapies that appear to help, without the prior support of the medical establishment. When those case histories become too obvious to ignore, then someone finds a way to get the clinical trials done.
Here is an example with Low Dose Naltrexone. It was used for treatment of Crohn's disease for well over ten years before someone at a teaching hospital in PA did clinical trials. The result of the clinical trials? Over 2/3 of the patients with acute Crohn's disease went into total remission in 3 weeks. With no side effects. That same hospital is now looking at doing clinical trials using LDN for hepatitis c, based on similar case histories. Without the case histories, the clinicals would never get done. But you seem to be making the opposite point, that somehow clinicals should be done first, before there is any evidence of efficacy. That is disingenuous, in my opinion. But, I know this - people with the same bias as you were arguing against the use of LDN for Crohn's all of those years, demanding to see clinical trials. How many needless bowel resections were done in that time? How many patients were ravaged by steroids, the SOC for Crohn's, in those ten years?
Let's just leave it at this: there is plenty of evidence that ALA is beneficial for hepatitis c patients. Those who are not on treatment might want to look into using it to protect their livers. Or they might not. Everyone is free to choose. God bless America!
Sometimes i get the feeling that some are trying hard to convince themselfs their not just throwing alot of money away for nothing. Or maybe they have a vested interest... Oh well, just my opinion. To each their own.
the rate applies to those who continue to carry the disease. They often succoumb to cancer finally and not just plain old liver failure.
the variance in the rates is because it depends on what genotype you are talking about, and what study...they all differ as to opinion somewhat, so that rate for the US I've seen as low as 1% as high as 5%.
in japan the rate is 7%....I believe this means either type 4 causes more free radicals, or else they are tying more deaths to the hcc than we are, and following/correlating the 2 conditions more closely, not sure which.
here's one study, I can't give an accurate number because the researchers can't agree. Still, if I were to take the midrange of say 3%...if it was 3% per annum....that would equate to 30% of us as an example, in 10 years if you follow.
here's that study: http://cme.medscape.com/viewarticle/560012_3
Mike, there you go again, we are talking about ala and hcv. Whenever you are asked to produce evidence on ala and hcv you always retreat to ldn and crohn's disease, that is a different forum. For the record, it appears ldn has some validity with crohn's disease and is being studied. Hmm, sorta blows a hole in your theory as to why ala is not being studied doesn't it?
Mike, you have been claiming that there is plenty of evidence that ala is beneficial why not share that evidence with us? Keep it simple, more evidence and less words.
Accumulating evidence suggests that plasminogen activator inhibitor (PAI)-1 plays an important role in the development of hepatic fibrosis via its involvement in extracellular matrix remodeling. We previously reported that alpha-lipoic acid (ALA), a naturally occurring thiol antioxidant, prevents hepatic steatosis by inhibiting the expression of sterol regulatory element binding protein-1c. The aim of the present study was to determine whether ALA prevents hepatic PAI-1 expression and fibrosis through the inhibition of multiple TGF-beta-mediated molecular mediators. We investigated whether ALA inhibited the development of hepatic fibrosis in mice following bile duct ligation (BDL), an established animal model of liver fibrosis. We found that ALA markedly inhibited BDL-induced hepatic fibrosis and PAI-1 expression. We also found that ALA attenuated TGF-beta-stimulated PAI-1 mRNA expression, and inhibited PAI-1 promoter activity in liver cells; this effect was mediated by Smads and the JNK and ERK pathways. The results of the present study indicate that ALA inhibits hepatic PAI-1 expression through inhibition of TGF-beta-mediated molecular mediators, including Smad3, AP1, and Sp1, and prevents the development of BDL-induced hepatic fibrosis. These findings suggest that ALA may have a clinical application in preventing the development and progression of hepatic fibrosis.
Alpha-lipoic acid decreases hepatic lipogenesis through adenosine monophosphate-activated protein kinase (AMPK)-dependent and AMPK-independent pathways.
We report here that alpha-lipoic acid (alpha-LA), a naturally-occurring antioxidant, scavenges reactive oxygen species (ROS) followed by an increase in apoptosis of human hepatoma cells. Apoptosis induced by alpha-LA was dependent upon the activation of the caspase cascade and the mitochondrial death pathway. alpha-LA induced increases in caspase-9 and caspase-3 but had no significant effect on caspase-8 activity. Apoptosis induced by alpha-LA was found to be mediated through the tensin homologue deleted on chromosome 10 (PTEN)/Akt pathway. Prior to cell apoptosis, PTEN was activated and its downstream target Akt was inhibited. Our findings indicate that increasing ROS scavenging could be a therapeutic strategy to treat cancer.
Effects of dietary alpha-lipoic acid on hepatic and serum lipid concentrations and the activity and mRNA levels of lipogenic enzymes were examined in rats. Rats were fed experimental diets containing varying amounts of lipoic acid (0, 1, 2.5, 5 g/kg) for 21 d. Lipoic acid profoundly decreased serum and liver concentrations of TAG, and also lowered serum concentrations of phospholipid and NEFA, and the concentration of cholesterol in the liver. A hypoglycaemic effect of this compound was also observed. Lipoic acid dose-dependently decreased the activity and mRNA levels of fatty acid synthase, ATP-citrate lyase, glucose 6-phosphate dehydrogenase, malic enzyme and pyruvate kinase in the liver despite that reductions were considerably attenuated in the NADPH-producing enzymes. This compound also dose-dependently lowered the mRNA levels of spot 14, adiponutrin, stearoyl-CoA desaturase 1, and Delta5- and Delta6-desaturases. In addition, lipoic acid dose-dependently lowered serum concentrations of insulin and leptin, but increased those of adiponectin. Lipoic acid appeared to reduce hepatic lipogenesis and hence decreases serum and liver lipid levels
The effect of thioctic acid on the glutathione dependent antioxidant system and activities of enzymes, generating NADPH of rats has been investigated in rats under conditions of toxic hepatitis. Injections of thioctic acid to animals with toxic hepatitis caused the decrease of glutathione reductase and peroxidase activities to the normal level. Reduced glutathione content also tended to the control level. Administration of thioctic acid to rats with toxic hepatitis also caused the decrease of NADP-dependent isocitrate dehydrogenase and glucose-6-phosphate dehydrogenase which might be associated with decreasing need of NADPH supply for glutathione dependent antioxidant system. Thus, obtained results have shown that thioctic acid may regulate manifestations of oxidative stress and the state of the glutathione antioxidant system.
AIM: To compare different preconditioning strategies to protect the liver from ischemia/reperfusion injury focusing on the expression of pro- and anti-apoptotic proteins. Interventions comprised different modes of ischemic preconditioning (IP) as well as pharmacologic pretreatment by alpha-lipoic acid (LA). METHODS: Several groups of rats were compared: sham operated animals, non-pretreated animals (nt), animals receiving IP (10 min of ischemia by clamping of the portal triad and 10 min of reperfusion) prior to sustained ischemia, animals receiving selective ischemic preconditioning (IPsel, 10 min of ischemia by selective clamping of the ischemic lobe and 10 min of reperfusion) prior to sustained ischemia, and animals receiving 500 micromol alpha-LA injected i.v. 15 min prior to the induction of 90 min of selective ischemia. RESULTS: Cellular damage was decreased only in the LA group. TUNEL-positive hepatocytes as well as necrotic hepatocyte injury were also decreased only by LA (19 +/- 2 vs 10 +/- 1, P < 0.05 and 29 +/- 5 vs 12 +/- 1, P < 0.05). Whereas caspase 3- activities in liver tissue were unchanged, caspase 9- activity in liver tissue was decreased only by LA pretreatment (3.1 +/- 0.3 vs 1.8 +/- 0.2, P < 0.05). Survival rate as the endpoint of liver function was increased after IP and LA pretreatment but not after IPsel. Levels of lipid peroxidation (LPO) in liver tissue were decreased in the IP as well as in the LA group compared to the nt group. Determination of pro- and anti-apoptotic proteins showed a shift towards anti-apoptotic proteins by LA. In contrast, both our IP strategies failed to influence apoptotic cell death. CONCLUSION: IP, consisting of 10 min of ischemia and 10 min of reperfusion, protects only partly against ischemia/reperfusion injury of the liver prior to 90 min of selective ischemia. IPsel did not influence ischemic tolerance of the liver. LA improved tolerance to ischemia, possibly by downregulation of pro-apoptotic Bax.
"Mike, you have been claiming that there is plenty of evidence that ala is beneficial why not share that evidence with us? Keep it simple, more evidence and less words."
With regard to this comment, isn't the thread about how dangerous the substance is? Doesn't that put the onus on Copyman, or whomever to provide the studies and data on how dangerous ALA IV therapy actually is?
Why not simply let people post data on LDN or ALA as it comes up?
It reminds me of the striving to get the 10 commandments removed from the lawn of the courthouse. I tend to walk by without noticing. It's the crowd of protesters I notice; the Christians versus the CLU on the lawn lawn of the courthouse duking it out.
Is it possible that you are having the unintended effect of creating publicity for the drug or treatment that you seem to oppose? Maybe if they were ignored they would have about 1/10 (or 1/100thth) of the posts that they commonly receive. Seems like one of them had about 350 posts. ; )
Having said that, I enjoy an argument, as long as it doesn't become a brawl.
Could you explain what's not simple about protecting the liver against fibrosis, fatty liver, oxidative damage, glutathione depletion, cancer formation and cirrhotic tissue damage? Is it that you don't understand how that would be beneficial to hep c patients? Maybe if you were more specific about the parts of the studies that you don't understand, I could explain them better.
I don't see how asking a question, but refusing to acknowledge the answer proves your point. It's like when my kid sticks his fingers in his ears and says, "lalalalalalala".
It does end the conversation though, because there is no where else to go in a logic-based system.
SOC is known to have many serious side effects even permant
and in some cases debilitating ones.Being heavily considering
this treatment I am being warned left and right even by MDs
about taking interferon right now.
I do not understand how anyone can call ALA dangerous in
I could make the case that ALA has helped me to get from
a FibroScan F2-F3 result to a FibroScan F1.
That is my clinical experience and other factors may
also play a roll.
Either way I did many ALA IVs and I mean many
and apparently it did not hurt one bit !
Major side effects are better sleep and overall feeling much
I am about to embark on SOC to surpress the virus beyond
detection level.Had a conversation with another Dr. yesterday
again warning me about Interferon and I should only consider
it as a last resort.
My head is about to explode !
Never mind ALA is dangerous , you have got to be kidding me!
Had a conversation with another Dr. yesterday
again warning me about Interferon and I should only consider
it as a last resort. "
It's so strange to me that i live in the greatest metropoliltan area in the world and yet no doctor ever warned me once that interferon could cause such type of problems as you just described. Can it lead to thyroid problems? Check. Can it cause autoimmune problems? Check. Can it cause exploding head syndrome - no.
They did say that it was a proven cure and could lead to me getting rid of HCV for good. As it has.
Never mind ALA is dangerous , you have got to be kidding me! "
Things that are NOT proven to work are indeed dangerous because people do die - every day - of end stage liver disease while they imagine that they are getting better and then are tested and have advanced in liver damage or HCC. Once your liver explodes it's exploded for good.
I'm not sure why you say that you are going to do SOC when it's quite apparent that it's so evil that you will not. Will you just do the riba part or riba and ALA and hope for the best? That is a serious question - without the interferon it's not a cure at all.
"I have serious issues with cognitive damage which puts the breaks on
every time I think about it."
SOC is not going to happen anyway you look at it. We are not the one's encouraging you to treat Bali. You are one who is continually telling us you are considering treatment and then WHY you are not going to treat. At this point, I don't understand why you keep putting it out there for open discussion when you dismiss it every time it's discussed.
I guess it's like having that entourage of doctors, the more opinions the easier it gets to make a decision right?
Lots of this is being reported as abuse. Please tone down the jokes, the personal stuff, etc.
This is the second time we've had to step in on this thread. We don't want to take it down or close it, so please keep things calm. Remember that you can discuss and debate without it getting personal.
"Dr. Berkson's assertion there is no cure concerns me greatly.
With that statement does it not concern you that he just might be taking advantage of people who are desperate? "
Yes. I am concerned about that quite a bit. I have stated that previously but you're asking and I appreciate that you're not simply attacking me as a Berkson follower (which is far from the truth) but probing and dialoguing on the matter. My concern is how he presents his information. While I don't have much problem with ALA separate from Berkson at this point and am at least interested in investigating that, I'm concerned how Berkson presents treatment for HCV itself, if he presents it as if there's no difference between SOC - interferon/ribavirin and IV ALA, as in neither one really deliver a cure. Whether he does this or not, I don't know but it concerns me because I think it's possible.
There are definitely those that do not believe in the concept of total cure. Whether Berkson is one of those or a charlatan who uses that to get patients, I really don't know and that concerns me also. Quite a bit, actually. Particularly when I've noticed some who have read his literature questioning whether SVR is actually durable.
Having said that, it doesn't have much to do with ALA itself. I also know doctors who treat people with interferon and ribavirin and the misinformation they spread either purposely, negiligently or sincerely concerns me greatly also - and the lives they endanger as a result concerns me even more. That doesn't mean that the drugs themselves are the problem though, does it.
So...not...not so crazy about my perception of Berkson. Not indicting him but have big concerns that I wish could be addressed somehow.
Very interested to know more about ALA however. Particularly from those with HCV who have decided to add it to their regimen whether in pill form or otherwise. Too bad Berkson seems to enter into every discussion on ALA. It seems people are far too willing to throw out the one with the other. If we did that with interferon and ribavirin because we encounter a doctor who's approach to treatment is dangerous, then we'd be missing out on the one and only known cure, wouldn't we.
Statement that there is no cure is, of course, wrong. And I agree with this. But do you know how many MDs, who are not hepatologists, think the same way? Plenty of regular, licensed medical doctors think that there is no cure, and tell this to their patients. My OBGYN recently told me this, and I had to educate him. Very good OBGYN, by the way, not a quack, but uninformed on this subject.
I read on several medical web-sites, geared towards patients, that there is no cure for hepatitis C. They talk about treatment and, maybe, "remission", but state that hepatitis C is incurable disease. It sounds very bad, discouraging, and is wrong.
Many doctors are just uninformed, because hepatitis C is not on their radar. It is not their specialty. Maybe Dr Berkson is also not adequately informed about the cure, or his information is outdated. His specialty is interative medicine. At least, he doesn't claim that he can cure HCV.
Tashka, the difference between Dr. Berkson and your ob-gyn is that Dr. Berkson directly treats persons FOR their HCV and your ob-gyn does not. They are part of his practice and he has put a study on PubMed about his triple-antioxidant therapy and his three HCV patients as the participants in his study. If HCV is not on Dr. Berkson's radar and he is inadequately informed, his patients are in a peck of trouble when he's using IV ALA treatment FOR persons with HCV. I don't think the issue is that he's uninformed. The question is whether he's adequately informing his patients or if he's misleading them, whether intentionally or unintentionally. If he was an OB-GYN it would be less of a concern. When he's treating people FOR their HCV, it becomes a greater concern what information he's presenting to them and how, the same as it is for a gastroenterologist who treats someone for their HCV and isn't giving them the correct information yet treating them with INF/Riba.
I do agree with you that Dr. Berkson does not claim he can cure Hep C. That is in his favour and different than the snake oil salesmen who claim their potions are a cure.
I did read his one interview verbatim and there wasn't anything in that interview that concerned me. What concerned me was his dialogue with me in an email and how he presents the "no cure" to his patients and if they won't go any further than Dr. Berkson then they'll believe that and may not seek out treatment or be aware that it CAN cure their HCV. That concerns me and I would think rightly so.
I think you have to study the virus a little more before jumping to conclusions.
The virus is highly virulent, people that reach no detectable virus in tests that detect one part in a million and that remain undetectable for a year are considered cures...people who relapse do so in a very few weeks, and end up back in the millions per ml. in no time...
so when it comes to whom to believe, a doctor stating there is no cure would be suspect in my view, He may have stumbled onto something that can be repairative, true enough, but to state there is no cure would seem like a way to suck gullible people in.
If there were no cure, then someone please explain to me how come there are so many people in here that ARE SVR, and have been for years, and are trying to help you? How could they not be detectable for umpteen years when this virus is so virulent unless the virus was eradicated?
1) I do not believe in Berkson or who ever instead of SOC.
2) I am still not 100% sure if ALA IVs are working in helping regenerate liver cells.
3) Contrary to many opinions on this forum , I am not a gullible follower the
complete opposite is the case. I have done the Berkson ALA Iv protocol
extensively followed by many bloodtests and scans to try determine efficacy.
Like my own personal mini clinical trial if you will.
I also challenged Dr. Berkson when the results did not proof to be what I
was looking for.
4) I am looking for ANYTHING that could help my state of health before,during or
after tx. and what could halt or slowndown progression.
Anyone who is interested in ALA IVs should look at the Berkson protocol since
he was appointed in the 70s by the FDA as th primary investigator on the subject.
No one has as much clinical experience with ALA as he does.
I am glad to share my experience and answer straight forward questions
to anyone who is interested. But by no means am I an advocate,
follower , promoter ect......
In my last meeting with Dr. B. after getting poor FibroSure results I decided it
is time to add SOC to my Alinia protocol.
I challenged him in person saying if my liver was truly regenarating the FibroSure
should have been a lot better. He said he did not believe in the test.
OK , so I told him without any proof I have to move on and I challenged his
believe that INF was not working by mentioning the fact that many do SVR.
At the end of that session he said , well maybe because he sees so many failures
he comes to that conclusion and maybe I will be one of the lucky ones.
So he wished me luck and that was our last meeting.
I returned to NY preparing for SOC. Which after all my efforts is a mental 180.
So now I am getting into what to take during tx and what not to take.
Come across CS`s protocol of predosing Rib, SAMEe+TMG during tx as interferon
sensitizers , tapering of at the end of tx , learnong about IR and test it
as well as doing another FibroScan for baseline stats since we have one now
in the city.
I thought I did not hear right when Dr. Park a colleague of Dr. Douglas Dietrich
told me I was F1. Best result to date ! I immediately repeated it one week later
different Dr. same machine rsult again F1. Recommendation from both:
time to wait , biopsy unneccessary.
Now at this point my anxiety level has caused an ALT flare up of 71 !!
5 weeks ago my ALT was 30 ! I am also feeling more inflammation
around my liver because of that.
I think I am as ready as I will ever get at this point.
Contrary to many on this forum I never ever completely ruled out SOC as an option.
As you know I am geno4 so good data and trial options are hard to come by.
I am not willing to wait any longer for some hopeful drug or INF free tx which
still is many years away , when I might be a good responder with little to moderate
So here is the hopefully final plan my man:
- predose Riba 14days , already on Alinia for quite a while , also start SAMe
and some other tx proven supplements. Ditch all other herbs ect...
- start injecting Peg 2 wk 1st PCR
- 2 more week PCR (4wk RVR mark)
- 8 wk PCR
- 12wk PCR ( decision time of wether to continue or restart with Telaprevir 2011)
I have boosted my Vit D to 74.5 , I am not insulin resistant, perfect BMI ,
geno 4 with Alinia , hopefully with minimal fibrosis
all good predictors that give me a green light.
Why wait when things can get worse. Who is to say I am not going to have an allergy
to one of the PIs ect.....
Well, I don't often tune into this channel but I have a quick question and quick observation.
I was in a pharmacy the other day in search of CoenzymeQ10, which I'm thinking of adding to my nearly non-existent vitamin regime. ( I only take liquid Viamin D3, thanks to GreatBird's suggestion.)
And there, on the shelf, alongside the Vitamin C's of the world, stood ALA! I was shocked to see it because I'd think the pharmacy would have to hire armed guards to secure it from the hound of the Baskervilles.
Anyway, I asked the pharmacist (who looked quite normal, not like a fanatic at all but appearances are deceiving) and he said ALA was inferior to (get this!) RLA!
So what is RLA or more specifically, R(+)-Lipoic Acid (active mitochondrial enantiomer)? Has anyone here ever mentioned it?
And to Bali: It's not my place to influence your decision but if I were in your position, I would wait for the PI's to go mainstream, if they do. My hope is that a G-1 (and likely G-4, like you) would only have to treat twenty-four weeks with that scenario.
Considering that most of the clinical trials are done on Genotype 1 as being the hardest to treat and then to a lesser extent on Genotype 2-3 and hardly on Genotype 4, probably because Genotype 4's are in other parts of the world where drug companies have less access to test subjects and a much smaller market to appeal to, being largely in the Middle East and Africa....
... it would be near impossible to *accurately* answer that question, don't you think?
Genotype 2 and 3's were long considered to be the same when it came to treatment responses and now it's become increasingly clear that Genotype 3's can be somewhat tougher to treat than Geno 2's but still not as hard to treat as Genotype 1's.
Therefore, Genotype 2 and 3 persons seem to be having to hedge their bets on what works for Genotype 1's when it comes to PI's and probably did likewise when the combination therapy of interferon and ribavirin came on the scene as well.
This is old...and I'm sure you're familiar with it ..
When this indicates a response rate of 66% for 36 weeks of treatment and 69% for 48 weeks of treatment - far superior to response rates for Genotype 1's on the same treatment .. I would say that .. for the most part .. you're likely as good as it gets with going on what works for Genotype 1's. Particularly if that study is reasonably reflective on what is known of treatment responses for Genotype 4's. I don't think any doctor treating a person with Genotype 4 is going to shy away from trying a PI on a G4 simply because there have been no direct trials done on G4. Rather, the consideration will be to take into account ALL of the factors that might come into play for that particular G4 person as treatment needs to be and should be individually determined based on their own biological circumstances.
Do you think you can look to whatever PI's are found to be effective for Genotype 1's? If not .. why don't you think so? Sincere question and interested in your answer.
I missed your TX plan...just read it. Seems reasonable. I would pre-dose with Riba too if I was doing a custom TX and I would also add Alinia to the mix. I was planning on doing both of those when I was doing my own prep and then the trial came up. I was also planning on going to the U.S. for the PCR's I wouldn't be able to get here in Canada. They wouldn't have done a baseline viral load for example, since I'd already had a viral load PCR in the current past year. I would have wanted that.
Anyway...plan sounds reasonable. The one thing you might want to consider adding is a thyroid antibody test and depending on that, keep a good eye on that throughout treatment.
Regardless of PI's, I was so mentally ready for treatment, I don't think I could have waited any longer. I just really needed to get this done and I was F1 as well. With the benefit of hindsight, I would still have done the same thing on SOC rather than clinical trial as it was simply my time, with all my life factors taken into consideration. It was going ahead regardless and I only found out about the trial when I showed up for my first treatment planning appointment and so it went.
Whatever you decide ... I wish you "a good ride" and success.
Well, not everybody is the same. So using only myself, I was F1 when I started treatment. At the SVR appointment six months post EOT, my doctor did a fibroscan and found no detectable liver damage at all and...as I have said here before .. told me with great flourish to get out of his office and never come back .. as I have no reason for follow up being all clear. Some kinda wonderful, eh? I hope the same for you.
I mean, the sign of hope for all of us is the ability to rethink things....when plan A fails, going to plan B is the true sign of rational thought.
I'm impressed that you challenged him...and yes he probably does ee a lot of failures...but he is a doctor..he has access to the stats, and the stats tell him that 50% do SVR...so saying most do not is not accurate..he has to know that...in fact 2 genotypes have cure rates of 80 and 90% respectively,,,that's nothing to sneeze at.
anyway, glad to see you are reconsidering.
I like your idea about adding the alinia and predosing the riba...
alinia had the most profound effect on type 4's so thats a no brainer...the riba is as well...though it could impede future studies or trial you might want to enter.
In the trials they look primarily for those willing to stick entirely to protocol...they are looking for what their drug will do under exact circumstances, and so don't appreciate any tweaking no matter how rational...as long as you are fine with trial exclusions down the road,,,
one thing, if I was F1, I think the PI might be worth the wait.
currently the drugs used do not interfere sufficiently with the transcription of vial replication which is why the PI type drugs are so hopeful, is because they do more in this areana and raise SVR from a dismal 50% for type 1's to a much more hopeful 75-80%.
Alinia also seems to interrupt the transcription phase, although it doesn't have quite as impressive of results.
In any case, I think you are on the right track with further consideration of your options...and just know we are in your corner and will be here for encouragement whenever you need it, whatever you decide.
I will say, I had to think long and hard about all the lipids since the virons also thrive on lipids...meaning they help the liver repair and get healthy, but the verdict is out on whether they help or hurt viral survival.
I questioned HR about this when he was here discussing the PCC research....and pointed out that ala, pcc, or any omega oils had that potential, and he was in agreement that one could not be certain as to the help or hurt therefore.
The operative thing for me, is I kept fats to a minimum while treating...but now that I'm done, and have relasped, there's good reason to protect the liver with omega's until I do get the right chemo to kill the buggers....and since the oils help limit the imflammatory damage, they just made sense even if VL did go up...as it happens, inflammation has gone down...so for now, things seem well in hand.
However I'm anxious to retreat as soon as better drugs are available.
Bottom line is to try to beat this thing before it beats us.
If you are feeling inflammation I'd wonder if your fibroscan was accurate. I didn't start to feel my hcv until stage 3/4 when the swelling began pressing on my rib cage....there are no nerves in the liver, so it's doubtful that stage 1 people would feel any pain.
-Tele & Boce work for geno1,2 not 3,4
-Other PIs still phase 1 or 2 and few years of
At this point what`s a geno 4 to wait for and why ?
Please tell me ?
With low viral load I either respond or not . If not than I will have
You might wait for a better drug while other predictors get worse.
- did last Fibrocan twice with two differnt Dr.s same result F1
- Did several ultrasounds recently liver normal size not enlarged
- I believe you can feel inflammation wihout having to have fibrotic damage
- I also believe that despite liver having no nerves the sorounding tissue
can get effected.
- few choices include geno 4
- you can end up in unfavorable arm and become resistant to that class drug
again not sure what exactly I would be waiting for ?
For what it is worth, I noticed an article about G4 treatment indicating improved results with SOC if nitazoxinide is added. I don't know anythig about this, but the article reports improved SVR results (79% vs. 50%). It looks like this study was specifically for G4 patients, though mostly were IFN naive.
Ribavirin Loading Before Starting Pegylated Interferon Therapy: Effect on RVR and EVR.
T. Hassanein, F. Barakat, D.L. Oliver, L. Petcharaporn, N. Karlen, K. Hall, L.M. Richards, E. Alpert, , University of California, San Diego, San Diego, CA; R.S. Pozza, K. Biando, , Southern California Liver Centers, Orange Country, CA;
Background and Aims:
Treatment of HCV infection requires the combination of Interferon and Ribavirin. Ribavirin at adequate dosing is essential during the course of therapy to decrease relapse rate and improve sustained viral response (SVR). The role of ribavirin in the early phase of HCV therapy and its impact on rapid viral response (RVR) is not well defined. RVR is considered the best indicator of SVR irrespective of viral and host factors. The aim of our study was to explore the effect of weight based ribavirin loading before starting pegylated interferon therapy on RVR and patient tolerance.
52 patients with HCV (54% Genotype 1, 34% Genotype 2/3, 11% Genotype 4/6) were included in the study. The mean age was 55 years, weight was 179 pounds and HCV RNA was 800,000 IU/mL. 26 patients were treated with pegylated interferon and weight based ribavirin (Group A) and 26 patients were treated with weight based ribavirin for 4-6 weeks before starting pegylated interferon therapy (Group B). Both groups were matched for viral load, age, weight, genotype and hemoglobin concentration prior to treatment.
At week 4 RVR was documented in 43% versus 55% in groups A and B respectively (RVR G1 36% vs 23%, G2,3 50% vs 100%, G4,6 0% vs 100%). There was no difference in ALT improvement or Hemoglobin changes between the two groups. At week 12 in genotype 1, 47% of group A patients were negative vs 50% in group B, while genotype 4/6 viral negativity was 33% vs 100%, respectively and for genotype 2/3 100% were negative in both groups.
Ribavirin loading before starting Pegylated-interferon therapy
1) did not impact RVR in genotype 1 but has a positive effect on genotype non-1;
2) was well tolerated;
3) had no significant impact on hemoglobin concentration at week 4 or 12 of therapy.
In summary, ribavirin loading might impact RVR rates in non-genotype one patients.
it's rather baffling these genotypes...like the predose study in this thread...there you see
that a 40-50% increase in RVR in 2 geno's, same applies in reverse...but usually it's type 1 that is considered the hardest to treat.
please note the geno 4's in the study on Willy's thread had a 13% higher RVR compared to 0% in the other arms, (A and C). Not sure what the final outcome was though...they left that info out for some reason. their conclusion did state:
Conclusions: TVR in combination with Peg-IFN and RBV had greater activity against HCV genotype 4 than Peg-IFN and RBV alone or TVR monotherapy. The potential role of TVR in combination with Peg-IFN and RBV in the treatment of HCV genotype 4-infected patients remains under investigation.
I'm not as familiar with your geno 4 research, so could you post the studies that show no improvements with PI's? Not that I doubt you, but just so we'll know.
If there's only slight improvement, then I could see not wanting to wait for sure.
In geno 1's it's a 25-30% improvement in overall odds, so it makes sense for most American's to wait and include the new PI's unless they are late stage.
What you need to know when buying R-Lipoic Acid..."the sticky truth"
R-Lipoic Acid (RLA) is one of the most important and exciting new nutraceutical compounds to hit the market. It is a powerful antioxidant, a critical co-factor in ATP production and has been shown to be more effective by a factor of 10 over the commercially available Alpha Lipoic Acid in several bio-tests. This implies that S-LA found in Alpha Lipoic Acid is interfering with the body's utilization of the natural R form. To learn more about what exactly is the difference between SLA and RLA click HERE
R-Lipoic Acid naturally polymerizes into a glue-like substance.
RLA is a highly unstable compound that easily breaks down into a sticky rubber or glue-like substance if it is not prepared, stored and processed correctly. Even under the best conditions, regular RLA is extremely unstable. Exposure to air, light, moisture and temperatures slightly above ambient drastically reduces shelf life and increases the formation of this unwanted bi-product that may impair its intended benefit.
Because of the complexity of the production, I am
now convinced that high purity and quality RLA is unlikely to
be available soon in product forms as inexpensive as are
regular vitamins. At Labochim's required selling price (even
in quantity), RLA could likely not be sold profitably in
capsule form for less than $3.00 per gram retail. Since a
reasonable capsule size would be 100 mg (3 or more per day),
this translates to a daily price of just under $1.00 which
only the most serious life extensionists or those with major
health problems are likely to embrace.
You would think however if it was so beneficial that professionals would have access to it because they would know how to handle it. It's a shame if it's really so potent and worthwhile that they can't do something to make it viable. I mean 10 times is a LOT. Maybe it's too much for the body - even as a supplement just meant for healing like ALA.....maybe they use the weak version because it is tolerated better, even via IV? If it's so useful to help IR it sounds worth the work to figure it out. How much that would help people with treatment rates! But it sounds like taking vitamin C for cancer rather than chemo still.
"....also, please note the study you posted only had 5 or 6 geno 4's in it....not sure this is sufficient to reach any conclusions. too small a sample IMHO."
The study you posted C210 (Willy) only enrolled 24 people and out of those only
25% were caucasian = 6 people !
It does give hope but it is not strong enough to hold of tx to wait which means risking
your overall predictors (viral load, staging , insulin resistance ect....) getting worse.
Predosing Riba has no apparent downside. If your Hgb drops it will do so either way.
This study shows efficacy and there is another one that showed improved response
in geno1 previous non responders
The best proven SVR results
for geno 4 remain tx with Nitazoxanide and yes those were all Egyptians so who
knows if ethnicity will be in my favor are work against me.
Predose Rib , Alinia onborad , low VL , optimum VitD level, no insulin resistance,
perfect BMI , Normal Iron level plus a few tweaking supplements are hopefully
going to do the trick. If not there will be a rematch with whatever PI looks good
when the time comes.
ALA is best as Thiotic Acid from European Source (ideally Germany by Ratiopharm)
That`s what the FDA appointed primary investigator says !
I use Metablolic Maintance ALA 300mg