Data about osteonecrosis

Does someone know published data about osteonecrosis caused by IFN treatment in other indications than leucaemia, eg hep traetment?

[drofi]

http://www.artsenapotheker.nl/c54947

Avascular necrosis with interferon alfa-2b in chronic myelogenous leukaemia

Australia - Out of a total of 426 reports involving interferon alfa-2b (Intron A

[desrt]

Just one of many reasons IntronA is no longer state-of-the art and most of us take our IFN pegylated.
Signing off from McDonald's.

[desrt]

You would have better luck searching HIV forums. Much more "published data about osteonecrosis" and IFN there.

Vielen Gluck

[drofi]

You did not read my posting carefully. The paper describes treatment of leukeamia, not hepatitis. Both diseases are unpleasant, but very different. While hepatitis causes thrombocytopenia very often, leukaemia caused thrombocytosis in the cases described in the australian paper. If you think these cases could have been avoided by using pegulated IFN insetad of IFN, you should have an idea "HOW" IFN causes osteonecrosis and why PEG-IFN could avoid this.
Statements like the one you have posted, telling opinions without any evidence for what is said, are a waste of time.