Aa
Day 21 .. Got some results today !!!?
I just wanted to Thank u all I am doing Sov/Rib treatment ... It's day 21 they called and... I am showing UNDETECTED !!! I am stopping by and getting a copy! Don't want to get too excited! Cause I can up and downs correct? My hemoglobin low WBC high... When I pick up paperwork I'll fill u guys in!!! They said don't stop taking meds got to finish 24 week treatment.. I know I do.. Just wondering if u guys wanna input on why? I mean I am finishing this no doubt!!! I just wanna Thank you all for your comments and support and all your helpful info on these stinking side effects! I am feeling fabulous today! Thank you all!
Hi sorry took me so long to see your post.
No worries about the stats I have known I have hep c for 26 years so lots of time to learn a lot of stuff. You have probably figured out by now that the reason that you have to treat for 24 weeks is because you have Genotype 3. It used to be that genotype 1 was the hardest to treat but now genotype 3 is but even so the new meds are still more effective than the old ones for genotype 3 just not as good as for genotype 1. And the current stats for genotype 3 who have never treated before they had 93% success with 24 weeks of treatment.
So you are on the road to getting rid of this thing and the odds are on your side
Good luck
Lynn
Lynn
No worries about the stats I have known I have hep c for 26 years so lots of time to learn a lot of stuff. You have probably figured out by now that the reason that you have to treat for 24 weeks is because you have Genotype 3. It used to be that genotype 1 was the hardest to treat but now genotype 3 is but even so the new meds are still more effective than the old ones for genotype 3 just not as good as for genotype 1. And the current stats for genotype 3 who have never treated before they had 93% success with 24 weeks of treatment.
So you are on the road to getting rid of this thing and the odds are on your side
Good luck
Lynn
Lynn
My husband has been testing negative. He was at end stage liver failure and now has liver and liver and kidney functions in normal range. Also 9 months sober.
Today we learned that his standard of care has been switched to the 24 week program even though he is type 1a.
We are glad to have found this forum to help us through the next three rounds of 28 days.
Today we learned that his standard of care has been switched to the 24 week program even though he is type 1a.
We are glad to have found this forum to help us through the next three rounds of 28 days.
Yes Riba has everything to do with low hemoglobin, as it is a virus buster, it is a red blood cell buster too. There is not a lot to be done as too much iron at this point is not good for your liver. I did try to increase some iron rich foods like raisens though, but don't take any iron supplements (unless your doctor says otherwise). You doctor will keep track of it and may adjust Riba dosage if your hemoglobin levels drop too low. Mine did.
Congragulations on UND.
Genotype 3 is the most aggressive and one of the hardest to treat genotypes.
Source; My thousands of hours spent learning the nature of Hep C.
You need to stay the course and complete the 24 weeks your Dr has advised.
Sounds like your on track for a new Hep C free life.
Best wishes
.....Kim
Genotype 3 is the most aggressive and one of the hardest to treat genotypes.
Source; My thousands of hours spent learning the nature of Hep C.
You need to stay the course and complete the 24 weeks your Dr has advised.
Sounds like your on track for a new Hep C free life.
Best wishes
.....Kim
At 3 weeks in and it sounds like it's going as expected. I see no reason to get nervous this early in the game. Just keep putting one foot in front of the other for the next 21 weeks and see how it goes. S/R is a successful combo for gt 2 & 3. The only thing I see is to watch that hemoglobin. Juice and other foods may help bring it up. Might ask your doc what you can do.
The riba may have something to do with it.
The riba may have something to do with it.
Thanks for your post and encouragement :-) really informational .. Helpful and I appreciate all of you!
Nope.. He said no signs of cirrhosis or no signs of any thing ... Not even damage maybe in the beginning because of my viral load but that's not showing now.. The stones IN MY LIVER ( not gallbladder or anywhere else) is on the back burner till we get rid if the HCV ( or kill the dragon.. Love it)!
Hey sweetie ... I did not mean that rude.. I promise that.. I don't understand all your numbers and your stats... Is that bad? I am going to keep doing the treatments .. I didn't know genotype 3 a was the hardest to cure ...and I do realize that I can relapse .. I was just happy for a minute.. He said no signs of any of the other and really no signs if damage just in the beginning my viral load was high but that's showing me the meds are working.. So basically don't get my hopes up till EOT results.. The 12 weeks after my treatment is complete? My dr just seems very positive! Also the stones ARE IN my LIVER but he said that's on back burner for now.. He likes the quote killing the dragon... Thought maybe y'all would like to know lol I find it a really good analogy myself ..Thanks for the info and I would appreciate a reply ... Please and thanks :)
Congratulations on your test results. It feels great. Just got my 4 week results last week and I am undetectable. I will be on Harvoni for 12 weeks. I understand that people that also have cirrhosis will be on Harvoni for 24 weeks.
I do not know for sure what u said .flyinlyn can u just give it to me straight... But he said there was no signs of cirroihus and no signs of cancer.. I figured that was the reason cause of relapse ..I have read enough of your guys posts to know it happens .. But I am staying positive everything happens for a reason good or bad.. So today I am taking the good ..
Hi
Congrats on being undetectable.
The reason for staying the full 24 weeks of treatment is because genotype 3 is difficult to cure.
It was found in clinical trials to have a higher rate of sustained viral response (SVR) after completing 24 weeks of treatment than treating for just 12 weeks. The chance of avoiding relapse are greater if you take the meds for 24 weeks.
Basically 83% ( with 93% SVR 12 for treatment naive) with 24 weeks of treatment vs 63% for 12 weeks of treatment
Copied from the AASLD treatment guidelines
The VALENCE study assessed the efficacy and safety of sofosbuvir (400 mg daily) plus RBV for 24 weeks in 250 treatment-naive (42%) and treatment-experienced (58%) subjects with HCV genotype 3 infection. The overall SVR12 was 84% and was higher among treatment-naive than treatment-experienced patients (93% versus 77%, respectively). These results suggest higher response rates can be achieved with a 24-week duration of sofosbuvir plus RBV than those reported for the 12- or 16-week durations studied in the FISSION (Lawitz, 2013b) (12 weeks, SVR12: 63%), POSITRON, (Jacobson, 2013c) (12 weeks, SVR 12: 61%) and FUSION (12 weeks, SVR12: 30%, 16 weeks, SVR12: 62%) trials. The primary reason for the higher SVR with extended therapy among treatment-naive patients was a reduction in the relapse rate from 40% to 5%. In sub-analysis, response rates were similarly high among those with (n=45) and without (n=100) cirrhosis (92% and 93%, respectively).
Congrats on being undetectable.
The reason for staying the full 24 weeks of treatment is because genotype 3 is difficult to cure.
It was found in clinical trials to have a higher rate of sustained viral response (SVR) after completing 24 weeks of treatment than treating for just 12 weeks. The chance of avoiding relapse are greater if you take the meds for 24 weeks.
Basically 83% ( with 93% SVR 12 for treatment naive) with 24 weeks of treatment vs 63% for 12 weeks of treatment
Copied from the AASLD treatment guidelines
The VALENCE study assessed the efficacy and safety of sofosbuvir (400 mg daily) plus RBV for 24 weeks in 250 treatment-naive (42%) and treatment-experienced (58%) subjects with HCV genotype 3 infection. The overall SVR12 was 84% and was higher among treatment-naive than treatment-experienced patients (93% versus 77%, respectively). These results suggest higher response rates can be achieved with a 24-week duration of sofosbuvir plus RBV than those reported for the 12- or 16-week durations studied in the FISSION (Lawitz, 2013b) (12 weeks, SVR12: 63%), POSITRON, (Jacobson, 2013c) (12 weeks, SVR 12: 61%) and FUSION (12 weeks, SVR12: 30%, 16 weeks, SVR12: 62%) trials. The primary reason for the higher SVR with extended therapy among treatment-naive patients was a reduction in the relapse rate from 40% to 5%. In sub-analysis, response rates were similarly high among those with (n=45) and without (n=100) cirrhosis (92% and 93%, respectively).
This is wonderful news and it does indeed feel so good.
Were you asking why your doctor has you doing 24 weeks? I assume it is because you have cirrhosis since they normally prescribe 12 weeks if you don't have cirrhosis.
Good luck!
Were you asking why your doctor has you doing 24 weeks? I assume it is because you have cirrhosis since they normally prescribe 12 weeks if you don't have cirrhosis.
Good luck!
Congratulations! Doesn't it feel great? You do have to finish all the meds. Unfortunately the PCR tests do not count down to 0. While they are low enough to give a lot of confidence that the virus is gone, in order to help make sure it stays gone, you need to treat for the entire time your doctor orders. To answer your question, it can pop back up as detected and then go back down again. But that does not happen often. It happened to a few people at my trial site and they still all ended up with an SVR. So just enjoy your undetected status and keep on taking those meds.
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