A) The risk for chronic infection varies according to the age at infection and is greatest among young children. Approximately 90% of infants and 25%–50% of children aged 1–5 years will remain chronically infected with HBV. By contrast, approximately 95% of adults recover completely from HBV infection and do not become chronically infected.
"Spontaneous Undetectable Hepatitis B Virus DNA Is Uncommon, especially without HBeAg Clearance
SUMMARY: Clearance of hepatitis B virus (HBV) DNA from the blood seldom occurs without treatment even after a decade, researchers reported at the 45th Annual Meeting of the European Association for the Study of the Liver (EASL 2010) last month in Vienna. Among people who experience hepatitis B "e" antigen (HBeAg) clearance, however, the likelihood of also achieving undetectable viral load was higher, approaching 50% at 10 years..."
"...."Spontaneous seroclearance of HBV DNA was a rare event, even after HBeAg seroclearance," the investigators concluded. "Lower baseline viral load and central obesity [were] associated with higher possibility of decreasing HBV DNA to undetectable level, whereas higher serum ALT level during follow-up associated with a lower possibility of HBV DNA decline."
Genomics Research Center, Academia Sinica, National Taiwan University, Taipei, Taiwan ROC; Research and Development, Bristol-Myers Squibb Company, Willingford, CT."
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