Dragonslayer's R7128 EOT test results

I thought I would post my End of Treatment (EOT) test results.

For those that are not aware, here are my details.
I am (was) genotype 1a, high VL, stage 2 grade 2 liver biopsy, possibly infected 20 some odd years. I was treatment naive.

I participated in the Pharmasett/ Roche phase I trial for R7128, a polymerase inhibitor.

I took 1000mg. of the PI twice daily for the first 4 weeks along with pegasys and Copegus (SOC). I then continued with just the pegasys and copegus for an additional 44 weeks.

I was UND by week 4 (6 log drop).

Week 48 (EOT) test results "HCV RNA not detected" (Taqman 2.0)

RBC, WBC,  (and all associated with them) were low. All other tests were Normal.

Next test in 3 months, then 6 months. If all is good That means SVR baby!!!

I know others were interested to know how I made out so I thought I would post.

[granitekonig]

congratulations! I just finished treatment, as well. I'm going to just wait till six months from now before I test for the virus. 4 week und and you are genotype 1 with high viral load?? So awesome. HIGH FIVE. =)

[JennyPenny]

That's wonderful. Congrats!

[pilgrim1951]

Great news!  Thanks for the update and for sharing with me a while back.  Our doc is great.  Next stop- SVR and then your forum ID will take on even more meaning.

[smaug48]

Looking good!  November will be celebration time!!!

Thanks for posting

[rita863]

Great News!!!!  You are heading toward SVR!!!!!!!!!!!!!

Nothing but the best to you my Buddy!!!

  peace
     Rita

[apache1]

Way to go!

Those PI's are proving to be a powerful weapon in our fight to eradicate HCV


Congrats

apache

[portann]

Wonderful about your RVR and EOT results. The pivotal significance of the RVR says it all.

And I'm still laughing about your twelve inch pianist joke. In fact, I got myself into a bit of hot water telling it. :)

Thanks for sharing and congratulations.

[willing]

Congratulations on finishing and on your encouraging results; all that's left is the wait ..

and many thanks to you and Epi for your good summaries of the R7128 trial. It  looks like a great candidate, I only wish the FDA's definition of "fastrack" was a bit faster.

[eureka254]

That 6 log drop in 4 weeks has my head spinning ... you gotta have it beat!  So great to see the PIs knocking down those geno 1s so fast... thanks for the details.

Congratulations... and keep us posted on those next SVR confirmations!  ~eureka

[epiphiny]

Way to go my friend!  I remember getting a 6 log drop as well and absolutely couldn't believe ot!  Woohoo, me thinks we're onto a winner.  But my 4 week test is due on Monday and I am really wearing that chicken suit everyone talks about!  Anyway, enjoy the knowledge that you are Hep C free, and enjoy getting your life back!!!  Looking forward to your SVR post!

Epi xxxxx

[winner727]

you worked very hard for what you got . I shake your hand !!   you seem extra happy , and posts like yours ,make me look to the future w some hope .    we all need to see & hear these things . thanks !     stay w us , I might need some advice down the line .     BRAVO !!!        bob