Elevated Alpha2 Macroglobulins

[Gidget234]

Recent FibroSure test results showed that I had elevated Alpha 2 Macroglobulins (303H). My FibroSure test score was 0.22, fibrosis stage: F0-F1 and necroinflammatory activity 0.17. What do these figures indicate, specificaly the Alpha 2 Macroglobulins
number?
Your advice would be greatly appreciated.
Gidget

[snook_man]

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[cheriums]

The significant numbers are the Fibrosis score and the ALT.  The trouble with a Fibrosis score F0-F1 is: there's an important difference between NO fibrosis/scarring and Stage 1.  Stage one means some progression of the hep in the liver, toward cirrhosis, has happened.  Not long ago, a lot of people said, it's not really a big difference because you don't need treatment, even at Stage one.  Opinions are moving toward early treatment now, however.  Recent study showed, the less fibrosis, the better your chances of responding to treatment.  Patients with Stage one fibrosis had better odds of responding to treatment than those with more fibrosis.  Also, at NO fibrosis, your disease may not progress in the liver for 10 or 20 years.  At stage 1, you may progress to Stage 2 in 5-7 years. There are no "rules," but that's the thinking now, based on watching what's happening to monitored patients.  And, that's how it went for me.  To Stage 1 in 24 years, then to stage 2 inside the 7 years I went between biopsies.  Any reaso not to have a biopsy, to know for sure?  Good luck!    

[Sam Hall]

mmm looks complcated i'd ask someone medicaly trained.
Lots of mice fs though
Sam Hall

[Gidget234]

Here's a breakdown of the complete FibroSure test results:

HCV FibroSure Results:                            0.22H
Fibrosis Stage                         F0-F1
Necroinflammatory Activity Score          0.17
Ncroinflammatory Activity Grade A0-No activity

Analysis:
Alpha 2-Macroglobulins, Q                              303 H  
Haptoglobin                               69
Apolipoprotein A-2                        133
Bibirubin, Total                          0.1
GGT                                       24
ALT (SGPT)                                35

Fibrosis Scoring:
<021 - Stage F0        No fibrosis
0.21-0.27  Stage F0-F1 (here's where I am )
0.27-0.31 Stage F1 - Portal fibrosis
0.31-0.48 Stage F1-F2
0.48-0.58 Stage F2 Bridging fibrosis with few septa
0-58-0.72 Stage F3 Bridging fibrosis with many septa
0.72 - 0.74 Stage F3-F4
>0.74 Stage 4 Cirrhosis

Necroinflammatory Activity Scoring:
<0.17 = Grade A0 - No Activity
0.17-0.29 = Grade A0 - A 1 (here's where I am)
0.29-0.36 = Grade A1 - Minimal activity
0.36-0.52 = Grade A1-A2
0.52 - 0.60 =Grade A2 - Moderate activity
0.60 - 0.62 = Grade A2-A3
>0.62 = Grade A3 - Severe activity

Gidget

[Sam Hall]

What was the middle bit again?
SHall