How were you able to get into a trial? Were you treatment naive? Or had you previously failed a treatment with Peg-Ifn? I can't get into a trial because I don't fall into either category. Had prior treatment with just plain interferon and ribavirin. Arghhhh.
Gilead Submits New Drug Application to U.S. FDA for Sofosbuvir for the Treatment of Hepatitis C 4-8-2013
HCV Treatment — No More Room for Interferonologists?
What are we to conclude from these studies? The low incidence of side effects, the relatively short duration of treatment, and the pangenotypic properties of the drugs are strong selling points of a sofosbuvir–ribavirin regimen and will probably lower the threshold for HCV treatment for both patients and physicians. The likely next step is to combine sofosbuvir with other direct-acting antivirals to enhance its potency. Is the interferonologist down and out? I do not think so, but it is surely time for reeducation.
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