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The caveat is, I have no idea if I cleared because of or in spite of them, and you research them at your own risk.
In part the referenced study reads:
"Based on the results of both studies, the researchers suggested that green tea polyphenols may be a useful therapeutic agent for treatment of hepatic fibrosis and a useful supplement in the treatment of NAFLD (Nonalcoholic fatty liver disease)."
Green tea has been in the news a lot lately. Hey, I had a bottle of Arizona Green tea with Ginseng and Honey an hour ago. Good, healthy stuff. Supposed to be good for your heart as well, even your gums.
The point about no big money, no big research dollars is also well taken.
Yes, right now SOC is peg and riba but before and after tx, we should be open to let's say, more "natural" agents -- as well as other healty living concepts -- for better liver histology and perhaps immune system enhancement.
-- Jim
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C'mon, it's a little to early for that kind of talk :)
Collodial silver might have some legitimate applications, however it is not effective against HCV.
Obviously you are convinced that Interferon/Ribivirin is "toxic" but in proven studies it has been shown to improve liver histology. It is the ONLY treatment available today that can eradicate the virus in some patients. Some of us have to act fast to suppress the virus, even if we can't get rid of it.
Everything, including the herbal remedies you are sold on can be toxic. To think that because it is "natural" it is therfore harmless can be a dangerous health mistake.
A lot of us here are treating because we had NO CHOICE but to treat, please take that into consideration. You sound like you DO have choices, how lucky you are. To choose to "watch and wait" means you probably have little or no liver damage so you have the LUXURY of choice.
If you are willing to put off dealing with the virus and can live with this nonlinear disease, that is your right. Some of us aren't as blessed.
Methinks medical technology has improved somewhat over what they were doing in rural N.M. back then.
Fibrosis research is extremely important, in the end - aside from HCC - it is the accumulation of fibrosis that is the essence of cirrhosis. If we could halt fibrosis progression even in the face of a mildy inflammatory liver, then maybe a lot of patients even without SVR could get stabilized. Fibrosis is a dynamic process. Its speed is dependend on individual variability in the response of the stellate system to proinflammatory signals from the surrounding infiltrate.
Several antifibrotics are in development to inhibit the activation of the predominant molecular aspect -Transforming Groth Factor beta (TGFbeta) activation that controls the transformation of these stellate cells into Collagen Fiber producing myofibroblasts "Transdifferentiation". If this molecular signaling pathway / machinery is oversensitive, then we have fast fibrosers as maybe Kalio or others here, while others are fine for decades. It is clear that the best thing to reduce or halt fibrosis is removal of the inflammation causing agent - the antigens of the HCV virus. But interference with the scar forming mechanisms that perform not a very useful but a deadly function in the liver is a realistic possibility ( "antifibrotics"). Chemically synthesized new chemicals/drugs that you can patent are the logical choice for the pharma industry , since they have to go through an expensive process of testing and proving in large trial towards the FDA that these drugs actually work for this indication and not do more harm than good.These cost need to be recovered (and are often "overrecovered"). If they would use natural substances for these trials they could never recover the cost for this scientific proof and others would simply start selling the same thing after the trial publications would come out. Overall this is a problematic situation, since many good medications are not developed in a scientifically sound way while some of these " natural substances" might be better/ less toxic than the patentable chemicals.
At NGI, many trials for new drugs against HCV and other viral diseases have come our way, since we tested if they worked and we got a look into the design and had the investigator brochures with all the details. We have seen drugs like Ribozymes come and go and knew the results way before any meeting presentation. We also had - and that brings it up here - some "Oral Interferon Inducers" to test and yes they were very IFN +other cytokines inducing.
I was told not to take any herbs or supplements on tx. Others say it is ok. I figure since no one really knows, I am not going to chance it. Once I am off tx, Im going to do a few things that I feel could help and at the same time not harm me.
I do read the info. you post here and I appreciate it. I try to keep an open mind.
http://tinyurl.com/yjc7av
It should take you to the study originally posted by St. George in the first post of this thread.
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Good eyes (and good observations) cause no one said it. What was said, however, is that thousands of poor sheep apparently are on combo treatment. I have the evidence if you scroll up to "C47".
As Beamishboy suggests, it's a baaaaad state of affairs.
I would recommend in the face of the seriousness of these issues to stay perfectly calm and analyze arguments. People in a caved in underground tunnel should calmly dig, never fight and waste no air. But of course, if the direction of digging is not clear...