Aa
French treatment
My Dr told me yesterday that there are pills being used successfully, without shots, for HCV in France. As you know there is so much info compressed into Dr visits that I never got the details. Has anyone else heard about French treatment? I believe Dr learned about this at the Liver Meeting but so far I can't find it.
Roy
Roy
There have been some relatively recent studies using oral compounds to bring patients to undetectable viral status; but to my knowledge, INF/riba was then used to complete the therapy and deliver SVR. An example of that is here, with the INFORM-1 trial:
http://www.hivandhepatitis.com/2009icr/aasld/docs/111309_a.html
“…None of the participants took pegylated interferon or ribavirin during RG7128/RG7227 dosing, but did received standard of care therapy using pegylated interferon alfa-2a (Pegasys) plus ribavirin after the initial 2-week dosing period…”
Generally, when a patient uses HCV protease inhibitor drugs and relapse, they are left with virus that has mutated and is resistant to the study drug; but if this treatment is ‘mopped up’ with interferon, these mutations are very limited. For this reason alone, it’s likely that IFN will continue to be required for some time.
I’m not sure that the France, or any other country will have an edge on any of this; most of the drugs now in trial are being tested internationally. I’d be curious to hear more about other options, obviously.
Good luck—
Bill
http://www.hivandhepatitis.com/2009icr/aasld/docs/111309_a.html
“…None of the participants took pegylated interferon or ribavirin during RG7128/RG7227 dosing, but did received standard of care therapy using pegylated interferon alfa-2a (Pegasys) plus ribavirin after the initial 2-week dosing period…”
Generally, when a patient uses HCV protease inhibitor drugs and relapse, they are left with virus that has mutated and is resistant to the study drug; but if this treatment is ‘mopped up’ with interferon, these mutations are very limited. For this reason alone, it’s likely that IFN will continue to be required for some time.
I’m not sure that the France, or any other country will have an edge on any of this; most of the drugs now in trial are being tested internationally. I’d be curious to hear more about other options, obviously.
Good luck—
Bill
Sorry but as far as I know these drugs are still many, many years away.
If they were not then the world wouldn't be so excited about tela and boce is my opinion.
If they were not then the world wouldn't be so excited about tela and boce is my opinion.
Yes my Dr said same thing and was using terms like "this is a much stronger med than TP." I would really like to know more, I'll go there if it looks better than what's allowed here.
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