Genotype 1a, 1b, comparison??

[snook_man]

My question is the difference between the two subs of genotype one? Did genotype 1b start as an A, and mutate to a B? Does anybody know the difference between the two? And also,I see from people on this forum, and many on other forums, that it seems like the 1b's SVR% are slightly higher than 1a's.. I have seen alot of 1a's relaspe or not respond.. Has anyone else seen the differences in response betwen the two, or are they the same? Has there ever been a study on SVR% geared at the sub categories of genotypes, or do they always classify them as one??Most of the geno 1's that posted here, of SVR, where 1b's..

Man, read some of the posts from the weekend , and you guys have been on the brutal on the attacks. Figured I'd post something, as I'm everyone's favorite target, and let some of the others take a breather..Besides, I don't think Rev has been himself, since I left..
Here is a link to some good articles. There is a Bill in congress right now, Bill 817. It is in the State of Michigan, and is for increased funding for education and awarness of organ donation.. It is awaiting House approval, so anybody in Michigan, write your letters to your representatives..
http://www.hcvadvocate.org/news/newsRev/2004/NewsRev-58.html

[cuteus]

that is one question i have been pondering about often, and last time I asked(months ago) there was no answer. I have found nothing myself, since many studies don't even breakdown by genotypes, I doubt if any wants to breakdown subgenos.
stay well

[MichaelT]

All I can provide at this time is that in pre-pegylated INF times, there was enough of a difference in SVR rates between a 1a and 1b to make note of it. With the advent of pegINF any meaningful differences in response to treatment has mostly evaporated.

[cuteus]

OHC has a site in geocities that I have had a hard time accessing lately, has anyone been there recently? could the url be re-posted, please?

snook: that site has stats of many of us that have/are done/doing tx and the results or progress. it might have a genotype breakdown, of course it is all informal statistical info.

[snook_man]

Do you know which geno was labeled worse, or was harder to treat.. Am I correct in saying 1a is the hardest and least likely to respond?? Would like to see info, or link to a study, if you have one..Thanks

[MKAndrew]

There is indeed a difference between 1a and 1b.  The main difference is genetic.  Dr. Blatt explained it this way, "There is a 98% similarity between humans and chimpanzees, but what a difference that 2% makes."  Dr. Blatt went on to say that the genomic differences between genotypes and subtypes are broad enough to consider all of the hepC strains as different viruses.

Genotype 1b is considered somewhat more difficult than 1a.  1b is known for its penchant for damaging the mitochondria of hepatocytes.  This can set off a more damaging immune response.

The mitochondria store the oxygen that powers the cell.  When 1b damages the mitochondria, diogin is expressed into the cytoplasm.  This causes the disorganization of cytochrome 3 inside the mitochondria.  Once the disorganization occurs, the mitochondrial wall becomes permeable, releasing oxygen into the cytoplasm.  The oxygen binds with hydrogen and becomes hydrogen peroxide, which causes extreme oxidative stress.  Cytochrome 3 then sets off caspases 3-6-9 which call for the apoptosis induction factor (AIF) to travel from the cell wall into the nucleus of the cell.  This can result in apoptosis (programmed cell death), and necrotic activity, all of which come from the immune system.  Since 1b causes the most damage to the mitochondria, it may also cause the most destructive immune response via active genetic signaling.  In other words, viral genetics change host genetics, which may add to viral entrenchment.

The other oddity about 1b is that transfusion recipients tend to have the 1b strain.  When you think about how many 1a's may have donated blood, we may be looking at a mutation that occurs sometime between blood donation and transfusion.

Also, some studies indicate that 1b's may be the true PKR binders, although there is some debate as to whether or not this phenomenon actually exists.  The theory is that NS5A causes a mutation in E2, which makes E2 genetically similar to PKR - SO similar, that E2 binds with PKR and prevents its phosphorylation, which is necessary to the antiviral response.

One solution might be the addition of beta IFN, which increases the expression of PKR, especially in LVL patients.

[snook_man]

Thanks, do you have alink to where that info came from. Good stuff, exactly what I was looking for.. So 1b is actually exactly as I thought, the 1a geno that mutated somehow and got stonger. That is promising, as I have seen alot of 1b's clear tx, I think Indy was a 1b also..

[Tallblonde]

You write: "There is a 98% similarity between humans and chimpanzees..."

After reading some of the weekend posts, it's difficult to distinguish which species some of us belong to!

Susan

[ringeding]

don't worry your pretty little head susan, we mostly all know you are definately far more evolved than most.  


okay.....so from here on in...maybe to simplify...you could just simply tell people to "go eat a bananna"  hows that?

[ringeding]

opps, but of course, that would not do much for the direction i suggested you take on the weekend would it? because, you'd still remain sanctamonious and superiour...okay i give...you really are superiour....

[Tallblonde]

Go eat a banana.

[ringeding]

thanks darlin...but only because i am sure you know more than we do...so it must be so....will bannana bread do?

[cuteus]

you made my day!! ROTFL
Thanks!!!!!

[ringeding]

hey did you get my e mail bout the t-shirt...now THAT made me laugh and had tears running down my face....thanks to you too sweetie pie....laughs a plenty today.....

where do banannas grow?????? maybe the more evolved could research that for me

[Tallblonde]

Nope, banana bread won't do.

Allow me to enlighten you on another important difference between humans and apes:

That "oh what a difference 2% makes" which MKAndrews mentioned in his post boils down to 1. a soul and 2. a conscience.  You, my dear, have neither.

When you posted on Saturday that I "deserved" to be childless (after six miscarriages), you proved what an utter monkey you are.

Susan

P.S. Cuteus...I'm glad you find Ringeding so amusing. That speaks volumes about your character.

[ringeding]

thanks for really proving yet another wonderful irrefutable fact.....

you really are quite intelligent and trainable after all....

i gave you clear direction......suggesting you use the phrase

"go eat a bannana" and by golly

YOU DID IT!!!, there should be a reward system in place for you

hummmm

[MKAndrew]

Snook,

I wish I had a link for all that stuff.  Actually, it comes from hundreds of clinicals I've looked at.  Some of them you can find on my website.

http://www.mkandrew.com

[ringeding]

just read your post, lets not take this so out of context susan....what i said, as tactfully as possible was,

with the high level of contempt you blatently display for those that struggle with poverty, abuse, drug addiction, alcoholism and mental illness, i am not surprised you wants are not being met at this time.  i then suggested the following:

perhaps a volunteer posisiton at a street level facility that offers support, help, guidance and just listens to those that struggle with the very issues you seem to fear so deeply and thus hold those souls in great contempt and dispise so....you may be fortunate to learn from them and their experiences, you might gain some valuable insight into the human spirit, learn wonderful lessons from those you dispise, and maybe look at why you REALLY feel that level of disgust for souls who have been dealt a different reality from your cozy privelidged one.  it is something you may learn from and benifit from greatly.  then maybe you will be more open to receive the gifts you seek.

[Tallblonde]

You write: "what i said, as tactfully as possible..."

"Tactfully"!  Now I'm with Cuteus ROFLMAO.

Thanks for the "lesson" in kindness and tact. You're one of a kind.

Susan

[ringeding]

UNCLE!!!!  i GIVE !!! YOU JUST DON'T GET IT DO YOU.  i will refrain from any other posts to you....its pointless, you are far too narrow minded.

[Tallblonde]

Great!  Is that a "Monkey's Uncle"?  Glad to know I won't be receiving any more posts from you!

Susan

[Notallowed]

I just wanted to say hello to everyone. I somehow stumbled across MHI and am really pleased with what I have been reading. I am a 52 uear old male from Kansas that has HCV and cirrhossis.I have tried the combo treatment a couple of years ago and got nothing but sick. I have an appt. with another specialist coming up in the middle of Aug. My regular MD suggested I see one again. I was diagnosed with HCV in 1998 and had a biopsy done the same year to confirm it and the damage done to my liver. I had been a very heavy drinker and drug user for years. I have another interesting problem to go along with this. I also have a seizure disorder since 1990 and have been taking Dilantin ever since. I recieved a letter from my doctor in 1998 stating that I should stop my medication immediately (Dilantin) because it is bad on the liver. We found out that I could not stay off of the Dilantin for long. This is how I found out about the HCV. I have seen some very good specalists in the past and so far they have told me the same thing; that I am between a rock and a hard place. I haven't seen a specialist in awhile and my yellow tint seems to be a little darker. I didn't mean to take up a lot of time,I just want to say thank you.

[cuteus]

cool name,lol. I won't ask what is not allowed. welcome. this place can be a godsend for many, a lifeline.
Is there any procedure that can be done to control the seizures? My coworker had some procedure done and is praising how it changed her life.
Good luck with your hepatology appt.
No need to apologize for the length of the post, we have seen longer...;-}
be well

[derail]

holy crappola
I'm away from forum for 9 hours having a bx done and look what happens ..major hissy fits additional Pi**ing and moaning matches and my pal snook is back. what's next Indy being drawn and quatered for supposed sexist remarks? All the business ventures in cohorts with Chevy have been in jest I caught that early It has been truly humourous I suppose that I must of said some socalled sexist comments in my banter with Chevy also, but haven't been called on it.Chev and I flirt with each other as often as possible, for no other reason that we like to and enjoy each others take on things Just like her and Indy My gosh, with all the senitive egos  around, lighten up It's only fun.
I quess next comes the cat fight complete with the bit** slapping. Indy and I are Hosting the event and Chevy will be selling tickets Buy early because we expect a large crowd and many have free passes already, so seating will be 1st come 1st served. We will consider jello wrestling, and wet tshirt contest and take additional suggestions for future events.
Maybe  loudest abdominal noises or strangest toes. Submit your suggestions by email to Whinenbitch@ iam pis*ed off .com

[Tallblonde]

Potassium bromide and sodium bromide are both very effective anti-seizure treatments that cause NO liver damage.  They were popular during the 1800's, but are rarely used today because they've been replaced by more modern medicines.  You may want to ask your doctor about this.  

Susan

[Tallblonde]

No need to sell tickets.  The match is over...and I've won.  The monkey is back in her tree where she belongs.

Susan

[jonihs]

I just want to share a quote from an AA friend.( see I am one of those drug addict, alcoholics you seem to have no compassion for)
Religion is for people who are afraid to go to Hell
Spirituality is for those of us that have already been there.
You see I'm perfectly content to put myself, all my loved ones, all my worries and woes in God's hands, and accept that whatever happens was His plan. Nothing, absolutely nothing, happens in God's world by mistake. That includes you getting HCV. I'm not saying that ANYONE deserves this disease, but for whatever reason, God has decided to give us this challenge. I look at it as another chance to prove that I am worthy of His love. How do you see it? As a punishment? Then that is what it will be. What doesn't kill me makes me stronger. It makes you bitter and vindictive. Which one of us is going to have an easier recovery and a content life despite of HCV?    Joni

[cuteus]

it is a well known fact here that some like to poke us monkeys with word sticks on her free time, when there is no horse poop to inhale. it keeps her busy between nail appointments...and you see the pouting and increased poking when the creatures don't want to play anymore, it has happened time and again.
ok...must go hide higher up in the tree where the stick can't reach...

[Tallblonde]

Just because I've never had a drug problem doesn't mean I don't have compassion for people who do.  But I also don't think drug addicts, past or current, are "COOL".  I think that's the comment that has branded me as being insensitive.  Well, so be it.  

I don't view my diagnosis as a punishment, by any means.  In fact, instead of saying "Why me?"....I say: "Why not me?"  I've even posted this personal philosophy to others who have slipped into self-pitying thinking.

Some playful banter between Scott and I last week has obviously been taken way too seriously.  I'm not a "rich, priviledged" person! In fact, I'm the only member of my family to graduate from college and I paid for every penny of it myself.  I've worked hard and have achieved some modest success in my career.  But I'd trade it all for a child and the experience of being a parent.  Unfortunately, I may never get that chance.  But even then, I trust God (oops...sorry...didn't mean to bring ups the "G" word") and his plan for my life.

You see, I'm religious and spiritual....and a whole lot more tolerant than many of the folks on this board who are bashing me.

Susan

[Tallblonde]

Keep climbing....you're still not high enough for me.

Susan

[derail]

I don't consider you won, If anything its a draw asuming you have won draws the conclusion that you are sanctomonious and right now I'm thinking that even on a good day you would give an aspirin a headache. get you nose down a bit and enjoy life more

[ringeding]

no, actually amoung the many comments you have made that have somehow left most feeling you are 'insensitive' (as you say), i think the one you said about a doctor suggesting you had ever done drugs, and your reply about the fact that "nothing about you LOOKED like you had ever done drugs" , well we all wanted to know exactly what someone that HAD done drugs "looked like" in your opinion...and then you went on to debase those who had ever done drugs at all, as "dirty, filthy, drug addict junkies" and then attempted to back peddled at the back lash of that comment, you still used reference to those as 'dirty junkies', thus negating entirely, your attempt at an apology...THAT was what rattled most of us monkeys, this one inparticular.