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Gilead Rollover Study
Here is my history:
I was a Null Responder to Standard of Care back in 2002.

I was in this Clinical Trial (NCT01435226) and was considered a relapser, finished 10-17-12. I didn’t clear the virus at 2 weeks (baseline 11,100,000 to 65), so I went on the Rescue Study with 2 DAA’s, Ribavirin, & SOC. I cleared the virus at week 16, but went back and forth between undetected and <25 for most of the time. I was undetected at 48, but after 1 month the virus was back.

Here is a link to the thread that I posted, http://www.medhelp.org/posts/Hepatitis-C/Gilead-study-GS-US-248-0131---phase-2-all-oral/show/1610899?personal_page_id=2264261

I just got a call from the study coordinator saying that Gilead has a rollover study, that consists of GS-7977, Peg, Riba for 12 weeks that I can participate in.

I think I'm going to go for it, it’s my understanding that Gilead will only use the 7977 with Peg/Riba for Genotype 1’s.

What do you think?

peace
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170 Answers
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Congrats on the 12 week.  I just went for my annual registry labs today and the nurse at the site told me they are having good results with their patients in this trial.  I am hoping that it works for you.  It sounds like if they get good results from prior non responders, then this may become the treatment for folks like me.

Best,
jsf52
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1815939 tn?1377995399
Congratulations on 12 weeks post EOT UND status. Best of luck.
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Will keep thoughts and prayers for an undetected 12 week post.  I went for my annual registry labs today and the nurse at the trial site said that they are getting good results with this trial.  It sounds like if they get good results then it may become the next treatment for folks like me.

Best,
jsf52
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thanks, hopefully this will work for everyone!

peace
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thanks, i appreciate it.

peace
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Thanks for the good wishes. Am keeping my fingers crossed. They do say it is showing good results and approval will come
In December.
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Music to the ears. Congratulations. A long time in coming. Hoping the same for me. I too go back at the end of January for the six month if next week is undetected. I can only imagine the joy you must have felt when getting the news
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thanks, it was wonderful, keep us updated...

peace
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Can't believe it Undetected 12 weeks after
Treatment. For the moment fourth treatment seems the one. Go in for 6 month test end of January when, if I am undetected they will call it SVR.
Even though all treatments
Included interferon it was worth it.  Since sofosubir
Will be approved in December worth in my opinion worth doing if you are a null responder.  It really seems they are near to getting rid
Of hep C. Good luck to all.
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1815939 tn?1377995399
Congratulations on being UND at 3 months post EOT. Wishing you SVR.
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sweet!!!...glad to hear it...

peace
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Great battle. You've won. Take a bow. Sing a song. You must be on cloud 9.

I just finished my meds and I'm waiting to hear the great news soon.
Your joy gives me hope.
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Congrats on the 12 week test.  SVR is coming soon!  Hope this is the one that will work for all of us previous non responders.  Best of wishes.  Hope that you get some R&R over the holidays.
Best,
jsf52
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Thanks for the good wishes. As eduardian said. I am taking a bow and singing a song!!!!  Of course after so many years hard to let it sink in and not think it will return but working on the positive energy flow.  But if I can get to undetected after so many bad responses it shows that almost everyone can get there. Peace, love and SVR to all.
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6800989 tn?1384931235
Just started with ribv  8 weeks back,, squashed viral load in two weeks and put my rejection of 1 year old transplant to bed, sounds like your doing fine post.
Wishing us all well
GO! --GL-7977
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just got the call, undetected post treatment 24 weeks.

i can't believe it...:-)

peace
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1815939 tn?1377995399
Fantastic news!  Congratulations! Enjoy your new Hep C free life.  : )
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This is fantastic congratulations. I have been following you ever since you started this thread. Great news!!
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Am so happy for you. Just today I wondered if you had been in as I know you are ahead of me. I go in on the 27th for my 24 weeks.   Hoping to follow you and stay undetected. What a journey we have been on over the last year and a half.  I think they say you are now cured if undetected at 24 weeks. Have an awesome day, night and life.
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thank you so much!!!
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thanks, i appreciate the support!!!
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thanks, we're all pulling for you!!!

peace
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Just got results from a biopsy last week and I am grade 2 stage 2-3, and I am GT 1a, Phenotype TT otherwise I failed and relapsed just like you did. I will probably try to wait for a year, but if my Hepatologist insists I do Sovaldi, it's great see you made it  
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thanks again, glad to hear you're working with a hepatologist.

peace
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1747881 tn?1358189534
"just got the call, undetected post treatment 24 weeks."

Big Congrats to you, I know know how hard you fought for it, made my day !!!!!

Peace to you too.
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much appreciated, hope everyone's day gets made!!!

peace
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Congrats OC, your posting though out this has been a pleasure and very helpful..........Best
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wondreful news..
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4670047 tn?1375734001
Wow!!! Fantastic!! So very happy for you! It's over, it's done, you can move on now!
Congratulations!
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thanks, i appreciate it.

peace
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yes, thanks!

peace
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thanks, i don't think it's sank in yet.

peace
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Congrats on the great news.  What a great way to start the year!  I go back in March for imaging and then have an appt with my hepatologist in May.  Hoping to hear that there is a new option for me - hoping that 2014 is my year for a cure!  
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thanks, i'm with you brother, good luck!!!

peace
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Went in for my six month test On Thursday and low and behold they told me that the gold standard is now 12 week to be considered cured if you are SVR at 12 weeks!!' Who knew hard to comprehend after 15 years it is gone. It appears there is a 1% Chance of relapse but pretty rare. After the six months results Gilead will ask if I want to continue for three years with a bi annual blood test and physical. My doctor who is very conservative wants to do a sonogram every six months to watch for liver cancer. He says that with fibrosis you run a small chance of developing liver cancer but with careful monitoring until the liver regenerates if it happened and was caught early is fully treatable. What a journey. But boy does the landscape for a full recovery look good for everyone with this disease.
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1815939 tn?1377995399
Congratulations! Enjoy your new Hep C free life. Best of luck.
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1747881 tn?1358189534
Congrats on the SVR, wishing you all the best
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NICE you and OC both on Sovaldi. That makes me want to try it. Congrats and best of luck. I'm a Grade 2 stage 2-3, GT 1a, phenotype TT and my Dr thinks I should wait for a few months to see what the landscape looks like.
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Congrats wondeful news! Sounds very promising for others also
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great news, that is awesome...i'm expecting a call from one of gileads offices to do some kind of followup tracking soon.

peace
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Congrats on the great news.  Hoping that 2014 is a good year for many of us.  I am going back for my regular 6 month imaging in March and then seeing my hepa doctor in May to discuss tx options.  Hoping to join your club by the end of the year!  
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Thanks for the posts.  For those going to treat there are so many options with or without interferon. 2014 looks like the year for a cure.
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OC & 3xl   ...good to see you both again with this news!
Congrats and be well

Will
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Thanks, I appreciate it and good to see you too...

peace
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6800989 tn?1384931235
Thumpervt
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Well it is official, six months after, and I still undetected, and cured. What a miracle.  This is such good news for all those needing treatment.  The new Gilead drug works.  Good luck to everyone going into treatment.  
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4670047 tn?1375734001
Wow! That's fantastic!! Now you can really rest easy! Happy for you!
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wow, that is such good news, i'm so happy for you!!!

happy new year!!!

peace
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1382010 tn?1279647204
Hi, I'm just starting back on the site and haven't seen my doctor since september. I did a 48 wk tx with interferon and ribivirun with undetected after 6wks and relasped a month after treatment. I kind of fell off the wagon and got really depressed. I'm ready to fight again and love all the good news I'm reading about new treatments and studies. I am genotype 1a. where can I find more info on the Gilead study? Congratulations on your recovery must be a wonderful feeling. This disease stays on my mind every waking moment.
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Welcome back. I can so relate to how you feel. This was my fourth treatment. But now the door has opened and cures are happening with these new drugs. I don't have the links to all the treatment results but it is on the site posted by others. There is my treatment with interferon and one without if you cannot or don't want to take interferon. Have faith and see your doctor plus the treatments are only 3 months. Good luck to you.
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