HCV 3a - 4 week VL results

[HCVinPDX]

My results have been posted on my medical chart but I haven't talked to the NP.  I'm on 150 mcg Pegintron 2b and 1200 ml ribavirin and completed my 4 week viral load test.  I want to note that the redipen leaks a lot and I think I lose some of my dose.
Anyway, VL started at 4,210,000 mL and 4 week VL is 968 mL.  I think this is a 3+ log drop based on my math skills (which are laughable).  Needless to say, I can't help but feel a little disappointed that it I'm not undetected.  How do my chances look for EVR and SVR?  Anyone know the stats?
Thank you!  

[desrt]

This study lumps 2s and 3s together, but shows similar results and might be easier to translate than bar graphs:

"82% of patients with the CC genotype achieved a sustained virologic response (SVR), compared with 75% with the CT and 58% with the TT genotypes..."

"... patients who failed to attain RVR .......... CC, 87%; CT, 67%; and TT, 29%....."

http://www.gastrojournal.org/article/S0016-5085(10)00841-3/abstract

[HCVinPDX]

Thank you!  I will discuss this with my hepatoligist.  Really appreciate the time you took to explain!

[ActingBrandNew]

Your VL drop was very significant however you aren't classified as an RVR because you weren't UND at 4 weeks. This can significantly change things for a G3. I know you don't have your IL28B genotype and that's unfortunate because since you aren't an RVR, if you are a CT or TT, your SVR percentage rate drops significantly. the difference if you are a CT is about 10% give or take...not so bad.....but if you are a TT, there is over a 40% difference.

So what I'm trying to explain to you is that you should request the IL28B genotype test. I'm 22 weeks into TX and just found out I'm a CT. I didn't clear the virus at 4 weeks either and had I been a TT, I would be doing 36-48 weeks of TX. They are learning a lot more about G3's and what influences TX success vs relapse. I know the thought of doing 36-48 weeks isn't appealing....but you don't want your 24 weeks of TX to be for nothing.

I'm not trying to discourage you with this information. I'm just sharing some info with you because I hope that you and everyone else clears this dreaded disease. A lot of doctors aren't up to date on all the new studies and most think the IL28B genotype only affects a G1....

I'm doing 28 weeks of TX because I'm a CT...would do 36 if my insurance would go for it.

[HCVinPDX]

Thank you.  I don't have my Il28B genotype so the chart doesn't help.  I talked to med tech and she said my VL drop of nearly 4 log is pretty significant so I will take that as promising and very good news!

[ActingBrandNew]

I'm a G3 as well. Your SVR rate if you do not have an RVR (UND 4 weeks) is affected by your Il28B genotype (CC TT CT) I will post a link below that gives a very easy to read chart for a G3 and SVR rates based on RVR EVR and IL28b genotype.

http://health.usf.edu/NR/rdonlyres/19465342-EE78-4A02-912E-2B19D795691A/0/UpdateontheClinicalCorrelatesofIL28BGenotype.pdf