Harvoni failure?

[48weeks]

I was just curious if any of our regulars have experienced or know of anyone who has experienced a Harvoni relapse or failure. I'm going into week 8 of 12 with good lab results and feeling good.  Again best wishes for all of us against this beast.  

[scottie24]

I'm alive today in spite of treatment, not because of it.  Everybody involved with creation of INF / RVN treatments should pay damages for the horribly inadequate warnings provided.

[mkapomaa]

Hi, One of my friend uncle got cured after 12 weeks course of Harvoni ( generic harvoni) from India. After 3 months later, the virus reappear again almost the same amount before initiating treatment. He is genotype 1b and the doctors says his liver condition is fine, no cirrhosis.
Me myself is currently taking Harvoni for genotype 6n and now 2 months duration. At 4 weeks, the virus was undetectable and I feel really exciting for my 12 weeks results. Finger cross!!!!?

[magdalenaiwaszko]

Thank you Frank, I will look into that. Appreciate your help.

[magdalenaiwaszko]

Hi Flyinlynn,

I'm trying to get more information about the relapses, I read that you experiences it too? My father finished a 12 week treatment (Sofosbuvir+Daclatasvir) about a month ago and just got relapsed. He is in Poland though and seems like the doctors are not that well informed, hence I'm trying to get as much information as possible. He is genotype 1 and had fibroscan with F4 result (one stage before cirrhosis) last year. Not sure of his viral count though.
Any advice, info, (perhaps you know of any experts I could contact) would be much much appreciated!

Best wishes

[Frank J. Perrotta]

Hi magdalenaiwaszko

I would suggest seeking help at a large medical university in Poland. You should be able to find a program for Liver Disease where your father will be able to enter.

I know that my university does accept very critical cases from around the world but I am sure that they would need the most up to date info on your father.

You could look over the site of my university for info it is called UPMC Center for Liver Diseases.

Best of luck.

[magdalenaiwaszko]

Hi all,
I have just found out that my father who has finished his 12 weeks treatment (Sofosbuvir + Daclatasvir) about a month ago has had the virus relapse. It was undetectable in all previous tests, but the recent test showed it. I was wondering if anyone can point me to the right sources, perhaps specialists and experts we could contact as in Poland (where we live) there doesn't seem to be enough information. We are not sure what to do next... He has had this horrible virus for more than 10 years, we were so happy to have cured it! But refuse to lose hope and want to keep fighting! Ahy help will be much appreciated!
Thank you

[Frank J. Perrotta]

My neighbor relapsed.

She nearly died on Interferon and Riba about 8 years ago and developed PIS.

I believe that she was on Harvoni for 24 weeks and was undetectable for 6 months (I am not sure about the time frame) and is just devastated.

I believe she is in her 70s. Her liver is not compromised and treatment has made her sick as a dog but the scum bag experts keep pushing her to treat. While no one will push for answers into treatment for PIS!

[h2sguy]

I just finished 8week harvoni treatment on feb3rd....got bloodwork done on feb 4th.....my hepatology nurse phoned me today while I was at work and left a message saying my result was less than 12 viral load count, ,which is apparently common after first bloodwork....more will be revealed april 28th on my 12week post treatment bloodwork ....im praying that 8weeks was enough to cure

[Nortforky]

Sorry, I wasn't sure my initial comment had posted since I had not verified email. Don't mean to duplicate.

[Nortforky]

I just found out I have relapsed after 24 weeks on Harvoni.This was week 12 post treatment and a viral load of 1.3 million. Liver enzymes still in the normal range, but that won't last. I took my dose each day at 6am and never missed. I followed all the instructions regarding supplements and took nothing to interfere. No drinking, etc.

Harvoni thinned out my hair a little bit. I had a 12.1 fibroscan which equals f-4.
Had failed daclatasvir in clinical trial.

[nan535]

I am so sorry to hear that you relapsed after 24 weeks on Harvoni.  What genotype are you? My husband, a liver transplant patient)  just went through 24 weeks also and has finally reached SVR 12. His genotype is 1b and his viral load was 92,000 when he started. He failed two prior treatments so we were very nervous about this one.
I know how you are feeling but don't give up. Talk to your doctor and find out what he/she thinks would be best to try and get going.  Trust me, if my husband
finally got there, you can too.
Good luck!

[pacman1372]

Hello Nort , I am extremely sorry to hear about your relapse .

How soon after stopping harvoni did u relapse if i may ask !!

I am assuming that you took it for 24 weeks as stated by you above .

Best wihses and keep that hope up , there are new meds around the corner with better cure rates ..

God bless you .  

[Nortforky]

Just found out I Relapsed after 24 weeks of Harvoni. 3years ago I failed a clinical trial of Daclatasvir and Aspunaprevir.Had a breakthrough at week 20.
I was f-2 before the trial. According to a fibroscan before the Harvoni I am f-4. I asked the doctor if ribavarin would help in the last 2 months of treatment, since I was undetected and wanted to stay that way. He said there was no data on that so I didn't do it. This treatment cost me $12,000 out of pocket. I am mad and think that my treatment was not well thought out.

[flyinlynn]

So when you say you were UND at 12 weeks was that 12 weeks after your treatment ended?

Most if not all are not detected on treatment what was you post treatment testing? What tests were done at what weeks after you stopped treatment?

Thanks wishing you the best
Lynn

[pacman1372]

Dear Jebwins , hello and i am sorry to hear about your relapse .
If i may ask :
1) Do u have any cirrhosis !!
2) the weeks that you talk about , are you taking about post treatment week 4,8 &12 ( eot + 4,8,12 ) or are you saying that you were clear till 12 weeks post treatment and then relapsed between week 12-24 .

please do elaborate .

wishing you a cure and good health .
best wishes .

[Jebwins]

I was tested at 12 weeks UD and then was detected at 24 weeks, Was tx naïve prior. Waiting...I guess for something else and then trying to get insurance to pay again is another story. I was UD at 4,8, and 12 week tests. Was so sure that I finally was cured. Was quite a shock, actually quite cruel. Took awhile took wrap my head around it but was just one of the very few unfortunate ones that Harvoni failed to work.

[Jebwins]

I started Harvoni in 12/14 for 12 weeks treatment. Was UD at 4 wks, 8 wks, and 12 wks. At 6 months was detected again with a vl 3.8 mil gen 1a. Didn't work for me, followed all protocol to a T.

[Jebwins]

I started Harvoni in 12/14 for 12 weeks treatment. Was UD at 4 wks, 8 wks, and 12 wks. At 6 months was detected again with a vl 3.8 mil gen 1a. Didn't work for me, followed all protocol to a T.

[Dee1956]

I am so sorry to hear this.  I can understand how you feel.  Words cant express how sorry I am.
Dee

[Dee1956]

I am so sorry to hear of your relapse. I know the feeling having relapsed the first time.  I was shocked that it didn't work.  After 48 weeks it was a huge disappointment.
Then 4 years ago I did the Incivek, I have been cured since then.
Hang in there!
Dee

[flyinlynn]

So sorry to read of you relapse.

Were you tested at 12 weeks post treatment? That is considered the test to indicate cured.

Earlier testing at 4 weeks if not detected is a good sign you will make SVR12 at 98.5% correlation. Never heard of a 6 week test just 4 weeks 12 weeks and 24 weeks.

Had you been treated previously?

I also failed 3 treatments with interferon based treatment and a 12 week treatment with Sovaldi and Olysio where I was not detected at EOT but was found to have relapsed 12 weeks after I finished treatment so I totally understand your disappointment,. I was devastated when I found out I had relapsed.

Just know there are new treatments coming next year that may be able to help the treatment failure from this generation of medicines we have now.

Good luck to all

[smmace01]

I am a GT 1, little cirrhosis. I took Harvoni for 3 months (per Doc) and was undetectable VL after 6 weeks.  Stayed that way until about the 5 month.  At the point I relapsed.  First treatment, obtained HCV in the early 80's.  Not sure what will be done at this point, but waiting for another drug to come back b/c the expensive blood test indicates Harvoni wont work on me.  Lots of $$ spent for a year to have this happen. :(

[darbara]

sorry to hear this I am on the same treatment and similar stats like you, this does scare me

[failedharvoni]

I also failed 12 weeks of Harvoni, I couldn't beleve it. I didnt know how bad I felt until I was on Harvoni and all labs normal.  
SVR< 15.
4 weeks EOT treatment it was back with a vengeance.
Started as:
Treatment naive.
GT1a
lowest level of compensated Cirrhosis.
1986 blood transfusion.
I am losing hope.
#HateHCV

[flyinlynn]

I saw some real world reports recently that 12 weeks of Harvoni with Ribavirin is having a few percentage points higher SVR12 rates than 24 weeks of Harvoni alone for prior null responders with cirrhosis. If memory serves I believe it was like 97% vs 92%

So glad I asked my doctor about adding Ribavirin to my treatment. I got the Ribavirin part way in so I took 24 weeks of Harvoni and 14 weeks of Ribavirin  

Best wishes to all
Lynn

[darbara]

did you take ribavarin with your treatment ?