Has anyone failed Harvoni treatment?

[burned74]

I am in my 7th week of Harvoni and waiting for my blood test results from last week. I am just wondering whether anyone out there in the real world has NOT achieved SVR with Harvoni.

Im a GT1a failed Riba and Reg 12 years ago. Probably had Hep C since 1974.

Doc said not to even bother with VL test until 12 weeks after EOT but I really wanted to know how it was going and I figured if I didnt clear unyil the end of 12 weeks I might want to extend it .

[darbara]

The cure rate for Harvoni is 90% no more and thats good enough for 90% of ppl who take it some of us maybe unlucky or have that hard strain.
On week 9 here V/L under 25
Liver AST, ALT normal range BUT BUT who knows later on how it goes.
Hoping for the best thats all we can do !

[Magnum]

As I mentioned in another thread, I am extremely hard to cure. I failed 5 treatments, with the last one (Interferon, Ribavirin, Victrelis), nearly killing me. Although I went from 2.3 million viral load before starting that last 5th treatment, I still didn't clear after the 12 weeks. So, the doctor reluctantly agreed for me to go another 4 weeks because I wanted to once and for all get rid of this virus. I shouldn't have done that. Although after 16 weeks I went down to 300 from 2.3 million on my viral load, I was still not cleared. The damage it did to my liver required me to have a transplant.

However, after a 24 week regiment, Harvoni cured me forever as the doctor stated last week. So, if it cured me, it will surely cure you. Hopefully you're on the 24 week regiment, but if not, chances of you being cured according to clinical trials is 98%. Best of luck...

Magnum

[Nortforky]

I did 24 weeks Harvoni and relapsed. GT1b. VL1.3million.

[scottie24]

Clinical trials data are biased and unreliable.  Fact of life.

[patra_]

Oops, I got that backwards as far as welcoming.

good you are back, burned!

LJB, welcome!

[patra_]

Burned, welcome to the Forum.  I, too, have wondered about the number who may have failed on Harvoni.  It seems, lately, that we are only seeing positive SVR results.  I hope those who fail will post that too, so we do get a realistic picture.

LJB, I am so sorry you have relapsed, but am interested in your actual tx.  did you also treat with Ribavirin as well as Harvoni?  what is your Genotype?  Also, did you post your relapse on the SVR or Relapse thread that nan535 started?  I ask about your genotype because Abbvie has just had DVA approval for a med to treat,specifically, Gt 4s, and BMS (Bristol, Myers Squibb) has just gotten FDA approval for Daklinza, for Gt3s.

I believe that, if we keep good records, one day soon someone will be able to do a study on real life SVRs and Relapses from those statistics, but it won't be useful unless everyone posts relapses as well as SVRs.

Both of you, I wish you SVR!

Blessings,

Pat

[48weeks]

Hey sorry to hear this and I know people saying been there and done that doesn't help. Don't give up!!

[LJB1963]

i DID 24 WEEKS OF HARVONIN AND I RELAPSED. I WAS DEVESTATED. I HAVE BEEN DOING VARIOUS REATMENTS SINCE 1989 AND HAVE ALWAYS BEEN ABLE TO GET A UNDETECTABLE RESULT , BUT AS SOON AS THE MEDS STOPPED , THEN THE VIRUS CAME BACK (2 FOLD)

[burned74]

My doc originally just asked for the typical blood work but I called him back and he readily added the VL.

Best of luck to you too.

[48weeks]

My history and yours are similar. I am also a gt 1a, and also going into my 7th week of Harvoni. I think insurance companies pressure doctors a little bit. I got the typical lab work last week, but no pcr until week 12.  .  My liver enzymes have always been high by 3x, even when I was undetected on Incivek, but now they are in the normal range which to me is unbelievable. Best of luck to you for SVR

[burned74]

Thank You Can Do for your reply.

I'm pleasantly surprised myself as I had another biopsy done in 2012. NIH used a slightly different scale but I was a 1.5 ish but below a 2. I also had a Fibroscan done at the same time and the result was  low damage as well.

I doubt I had a reversal of damage so maybe the first biopsy was not quite as accurate?

Another interesting thing was that I was a 1b in 2004 but when NIH tested I was a 1A.

[can-do-man]

No drug has a 100% cure rate yet but he odds are way up there. Curious though as I looked at your profile and seen you was stage 2/2 back in 2004 and likely have had Hep C for 40 years. Has your doctor said anything about your current liver condition? Hopefully your not cirrhotic but if one is or even borderline and you are a past treatment failure with type1a 24 weeks should be the treatment time not 12 weeks.

Your doctor should be doing a PCR during treatment not just one at 12 weeks post. Wishing you the best.