would not surprise me at all, read an article earlier that there is a hepatitis virus in mice, dogs, turkeys and several others. I have had dogs all my life, but also have got them their vaccinations. I posted earlier that we had a cat that had hep and the vet said it was contagious. Thats why mom gloved up and wore a mask. Hep C had to come from somewhere, makes you think.
Viral Outbreaks in Dogs Yield Clues on Origins of Hepatitis C
By CARL ZIMMER
Published: May 30, 2011
Hepatitis C is, in some ways, a high-profile disease. Worldwide, an estimated 200 million people are infected with the virus. Some of them will suffer cirrhosis, liver cancer and even death. Celebrities like Steven Tyler of Aerosmith and “American Idol” have spoken publicly of their infections.
But mysteries still shroud the disease. Typically spread through drug injections, blood transfusions and sexual contact, hepatitis C can quietly cause liver damage for 20 years or more before victims become aware that they are ill. “Worldwide, it’s causing devastation,” said Brian Edlin, an epidemiologist at SUNY Downstate Medical Center in Brooklyn.
Its origins are even more puzzling. Hepatitis C is a distinct disease from hepatitis A and B; it belongs to an entirely different virus family that includes diseases like West Nile fever and yellow fever. Scientists have searched for years for related viruses in animals to figure out how it evolved into a human disease.
“Identifying the species reservoir of hepatitis C — one of the most common and deadly of all human viruses — has been something of a holy grail in studies of viral evolution,” said Eddie Holmes, a virologist at Penn State University.
Now scientists have gotten an important clue, finding a close relative in an unexpected host: dogs.
The discovery, published in Proceedings of the National Academy of Sciences, “represents a major step forward,” said Dr. Holmes, who was not involved in the research.
The finding came as a surprise to all the scientists involved. Researchers at Pfizer were investigating virus outbreaks in dogs in shelters across the United States. They swabbed the noses of dogs sick with respiratory diseases and searched for viruses. In some cases they could not isolate a known virus, so they sent samples to the Center for Infection and Immunity at Columbia University, where researchers specialize in finding new viruses.
The Columbia center found that six of nine dogs in one outbreak and three of five in another shared the same unknown virus. Nasal swabs from 60 healthy dogs showed no sign of it.
Amit Kapoor, a Columbia virologist, compared the genetic material of the new virus to known ones. His analysis revealed it was closely related to the hepatitis C virus (HCV for short). “I was not expecting anything like HCV,” Dr. Kapoor said. Like many other researchers, he assumed that it had evolved from a primate virus, because chimpanzees can be experimentally infected with hepatitis C.
But as Dr. Kapoor and Peter Simmonds of the University of Edinburgh analyzed more genetic data, the link continued to hold. Dr. Kapoor and his colleagues have called the new virus canine hepacivirus, or CHV for short.
The Columbia researchers collaborated with hepatitis C experts at Rockefeller University in New York to compare the two viruses. Canine hepacivirus infects the airways of dogs and is present at low levels in the liver.
Based on the genetic similarity of the two viruses, the scientists estimate that they share a common ancestor that lived 500 to 1,000 years ago. “It’s really quite rough,” said W. Ian Lipkin, the director of the Center for Infection and Immunity and an author of the journal article. “This is not something that happened recently, but it didn’t happen hundreds of thousands of years ago.”
The researchers see three possibilities for the origin of the viruses. The least likely is that dogs acquired hepatitis C from humans. Another possibility is that dogs and humans both acquired the virus from an unknown animal. This is the sort of evolution that gave rise to the 2004 outbreak of SARS. At first scientists found the virus in the catlike palm civet of Southeast Asia. But later research revealed that the virus actually started out in bats and then spread to palm civets and humans.
A third possibility — one favored by Dr. Kapoor — is that the virus started in dogs, and then evolved into a liver-infecting disease in humans.
“The evidence we have favors an origin in dogs,” Dr. Kapoor said.
To test these alternatives, Dr. Kapoor and his colleagues plan to search for hepatitis C-like viruses in dogs from other countries, as well as in foxes and other species of carnivorous mammals.
Even before that mystery is resolved, however, researchers expect to see some benefits from the discovery of canine hepacivirus. In the current issue of the journal Nature, Dr. Edlin argues that much more needs to be done to fight the hepatitis C epidemic. Along with better surveillance, he sees a need for research into antiviral drugs as well as vaccines. (Currently there is no commercially available hepatitis C vaccine.) Researchers may now be able to study CHV in dogs to get insights into hepatitis C in humans.
“I’m sure this will be helpful,” Dr. Edlin said.
http://www.nytimes.com/2011/05/31/health/31hepatitis.html?_r=1
will - +1Will
nygirl - ha ha this is true - actually in the middle of the night last night the thought did cross my mind that it would be just my luck to be reinfected by my dog once I am done treating. The odds are just about the same as how I originally contracted it.
We're a bunch of wierdos but at least we know where we got the HCV from......gotta get our dogs on SOC right away so we don't get reinfected!
I just said to my dog " I knew it was you all along "..... lifts his head looks at me ,drops it back on the floor and goes back to sleep?? Doesn"t much care!
I wasn't joking Deb - lol
true story we had a cat named bubbles in the 70's that had hepatitis the vet told my mother she could try to save the cat or he could euthanize him, because he didn't think the cat would make it. My mom put the cat in a closet a walkin and kept him away from the other kitties and the family. she put on masks and gloves and tended to that cat for several months, handfed him rice and soft food, he recovered and the vet couldn't believe it. Just saying you never know
hahaha I had a fight with my dog and punched him and then realized my knuckles were bloody........
i was driving down the road and my tire went over a patch of blood where my dog bled and when I changed the tire..........
My dog used my nail clippers when I wasn't looking...
I used my dogs razor that he uses for manscaping............
You have a great sense of humor Annie it's warped like mine ;)
Blood to blood - let's see - I was cleaning a cut on my dogs foot and a little of the blood accidently splashed into my eye
I agree now if I tell anyone I have it I'll say I got it from my doberman. Although exactly HOW you get it from a dog seems like it might be rather a gross story..........better just to say I did a lot of drugs in the 80s after all. :O
Interesting piece - thanks for posting.
There are some very disconcerting virus' showing up in humans now vis-a-vis the bushmeat crisis. According to the CDC:
"Approximately three fourths of human emerging infectious diseases are caused by zoonotic pathogens (1). These include agents responsible for global mortality (e.g., HIV-1 and -2, influenza virus) and others that cause limited deaths but result in high case-fatality rates and for which no effective therapies or vaccines exist (e.g., Ebola virus, hantaviruses, Nipah virus, severe acute respiratory syndrome [SARS]-associated coronavirus)."
Fascinating!
Thanks for posting
dointime
Mystery solved!!! I got it from my Saint Bernard, or was it the rascally Golden?? Very interesting article an thanks for sharing it.
Anne
frijole