Aa
High virus load
Hi,
I have started treatment pegasys + riba and feel much better as before. Virus load was 1.36 E6 it means high. 1b. Only physically weakness have influence to my body now. All other is OK after 5 weeks treatment - Alat 32 (160 before), all blood tests are OK. I know 1b is hardest for treatment so I would like to know - is it better to start treatment with high V load or better result is with low ?
I have started treatment pegasys + riba and feel much better as before. Virus load was 1.36 E6 it means high. 1b. Only physically weakness have influence to my body now. All other is OK after 5 weeks treatment - Alat 32 (160 before), all blood tests are OK. I know 1b is hardest for treatment so I would like to know - is it better to start treatment with high V load or better result is with low ?
almost all studies claim the higher the viral load the lower the sucess rate . however they do not correlate this with viral load reduction and the speed of response to treatement . 5 months ago i had viral load 10.5 mil 3 months ago 6.4 mil 2 months ago 3.8 mil. i startet tx at this point and feel my chances of sucess are about as good as someone with a low viral load < 800,000 . viral loads fluctuate greatly i think that the amount of liver damage the amount and speed of viral load reduction and the paitents age and overall health are more important factors .
http://janis7hepc.com/Viral_Loads.htm
I am not familiar with 1.35 E6 determination - is it exponential? Can you give it in IU/mL? The address I posted here gives some basic info on viral loads and some equivalency information.
Low viral load is supposed to be a predictor of success in treatment but loads can vary significantly from day to day. It sounds like you are doing well on treatment
I am not familiar with 1.35 E6 determination - is it exponential? Can you give it in IU/mL? The address I posted here gives some basic info on viral loads and some equivalency information.
Low viral load is supposed to be a predictor of success in treatment but loads can vary significantly from day to day. It sounds like you are doing well on treatment
Ib is supposed to be the hardest but as for making real substantial difference to a 1A I don't know really. I'm both 1A and 1B...and the doctor said it really makes no differnce that I have TWO at all it's still killing virus. Since that was Jacobson who said so I don't think it makes that much diff.
If you think 1.36 E6 is high, try mine baseline of 72.0 E6. About VL indicates is level of infection at a given point in time.
It also provides an indicator of whether you are responding to tx but does not appear to provide any prediction on chance for SVR. As some here can testify, even with low VL's at start of tx, they were not, or have not, attained SVR while others with higher VL did attain SVR.
Bottom line is that no one can predict how someone will respond to treatment. Will someone respond to tx? What sx's will a person experience while on tx? Will a patient attain UND and/or SVR? Will they experience a breakthrough while on tx? No one can predict and if someone thinks they can, they may want to go a get a lottery ticket ASAP!
It also provides an indicator of whether you are responding to tx but does not appear to provide any prediction on chance for SVR. As some here can testify, even with low VL's at start of tx, they were not, or have not, attained SVR while others with higher VL did attain SVR.
Bottom line is that no one can predict how someone will respond to treatment. Will someone respond to tx? What sx's will a person experience while on tx? Will a patient attain UND and/or SVR? Will they experience a breakthrough while on tx? No one can predict and if someone thinks they can, they may want to go a get a lottery ticket ASAP!
Great post - you made some excellent point there.
It's all a big crapshoot - I've just started to REALLY believe that because you know even WITH odds...there is always a number to go either way and you can never know which side you are on, ya know?
But as long as there is a 1 in 100 chance...it's worth it.
It's all a big crapshoot - I've just started to REALLY believe that because you know even WITH odds...there is always a number to go either way and you can never know which side you are on, ya know?
But as long as there is a 1 in 100 chance...it's worth it.
"But as long as there is a 1 in 100 chance...it's worth it."
and in fact the chances of beating Hep C is like 50% or better if you are geno 1. I figure that's worth it for me. it took me a long time to get to the point of being ready to commit to treatment. but at age 50 i figure it's time. i am geno 1, stage 1 grade 2. i just want to stop the damage before it gets worse. it's a big decision. one that i don't take lightly. but the alternative of liver failure down the road is much scarier. so i will give it a good try and hope and pray for the best. from what i read combo therapy will still benefit the liver even if it doesn't cure Hep C. although, that is what my expectation is. be well.
and in fact the chances of beating Hep C is like 50% or better if you are geno 1. I figure that's worth it for me. it took me a long time to get to the point of being ready to commit to treatment. but at age 50 i figure it's time. i am geno 1, stage 1 grade 2. i just want to stop the damage before it gets worse. it's a big decision. one that i don't take lightly. but the alternative of liver failure down the road is much scarier. so i will give it a good try and hope and pray for the best. from what i read combo therapy will still benefit the liver even if it doesn't cure Hep C. although, that is what my expectation is. be well.
Well, I am a HCV Geno-2 and my VL was only 750k and I relapsed.
I was less than 10 at week 10 and 24 but the 6 month after check came in with a 460k VL.
I was less than 10 at week 10 and 24 but the 6 month after check came in with a 460k VL.
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