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1769355 tn?1319204162

I need your help,please!

I really like to know some about IL28B test,that often I 've read in the your post.If I've well understanding this mean:the genetic variation in IL28B. But what  it  mean ?genetic variation in Il28B?
Last time that I see the infectology doct.I didn't Knew  what ask to him ( i wait to start interferon cxonbination therapy) didn't knew about genotypes! All that now I know is thanks to your post and nex time my doctor have a lot to explain to me!!So' please help me out,if you know about this kind of test !!!
    thank you a evrybody in the community!!
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Avatar universal
Thats a good question ..and one I don"t know the answer to.  I know that this particular finding on the IL28B   was an "ad hoc" to the   111Advance Trial (tela)

I do know there was  15% chirrotics in that trial..  however it did not mention how many were looked at for the results in the IL28B findings.

Will

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Avatar universal

Do CC cirrhotics treatment naive have the same odds?
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Avatar universal
And if you RVR...by that study  your chances are about 95%...there is no better odds than that in this game I have ever seen  :)
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Avatar universal
HI Cin....yes as a tx. naive that study showed 90% success with Tela  and the CC...time to jump in the pool.....hee hee
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1253246 tn?1332073310
Hey Wil-I didnt see the studies on the CC and triple therapy-Thx for posting that!!!!Thought ti was for soc tx only....Now im at 90%??????? cindy
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Avatar universal

The IL28B gene marker test is a blood test sometimes done to predict success to HCV therapy. It is not what Geno type you are...that is a completely different and separate blood test. Do you know your HCV geno type?. If you have Geno type 1 (for example) the results in studies doing triple therapy with Incivek ..showed the following results for the  three different IL28B alelles.

treatment Naives(never before treated) CC allele: 90% success
                                                        CT           71%
                                                        TT            73%

Not all doctors advise the test as  there is still a approx. 70 _75% chance of success doing the triple therapy regardless of what IL28B aleele  you are.

Good luck...the study I referred to is listed below...

Will

http://www.internalmedicinenews.com/news/gastroenterology/single-article/telaprevir-ups-response-rates-across-il28b-genotypes-in-hepatitis-c/6659c18157
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1253246 tn?1332073310
The IL28B polymorphism test is a genetic test to see which alleye you carry.You get one alleye per parent.It can be CC (which increases the chance of SVR) CT (somewhere in the middle) or TT (which is not as good as the others).The  is  a determining factor for SOC which is for riba and interferon tx only Does not apply in triple therapy.


The CC alleye has also been associated with a  3 fold increase in the rate of SVR.It is one of the many factors that can influence response rates to therapy(SOC).

Not to be confused with the different types of genotypes of Hep C.  cindy
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