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Interpretation fibrosure

this is what I received from the lab
(HEPASCORE (R)
GGT  22  u/l 3-95
BILIRUBIN, TOTAL:     0.8   mg/dl      0.2-1.2
HYALURONIC  ACID:    63   ng/ml      5-57
ALPHA 2 MACROGLOBULIN    257    mg/dl   106-279
F0-F1      25.5%
F2           17.0%
F3            21.0
F4            36.5%
does this tell anything I have been trying to get answers for 2 years now with limited access to health care I finaly talked my PCP into writing the script after looking it up in Quest Diag.when I took it to my GI and he did not know how to read it any help would be great thanks to all for taking the time to help
Best Answer
1747881 tn?1546175878
Hepascore is figured differently than Fibrosure so this link may be of more help.

http://www.clinchem.org/content/51/10/1867.full
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1747881 tn?1546175878
The best I can tell it should have a score which I don't see, you can look at the link I posted at the bottom of the last post or this link

http://www.fairfoundation.org/news_letter/2010/02june/Fibrosure..pdf

Hope that helps
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Avatar universal
with F2&F3&F4=74.5 what does that mean
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1747881 tn?1546175878
Interpretive Information


A HepaScore <0.55 is considered “negative” and indicates a METAVIR score of F0 or F1.

A HepaScore ≥0.55 is considered “positive” and indicates a METAVIR score of F2 to F4.

The patient-specific probability (P) of having a particular METAVIR score is based on the HepaScore sensitivity and specificity and the prevalence of liver fibrosis in either the entire population or the subset thereof (population described in the Clinical Background section).

The negative predictive value (NPV, probability that a negative test correctly indicates the absence of significant fibrosis) = P F0-F1.

The probability of a false-negative result =Σ(P F2 + P F3 + P F4).

The positive predictive value (ie, PPV, probability that a positive test correctly indicates significant fibrosis) = Σ(P F2 + P F3 + P F4).

The probability of a false-positive result = P F0-F1.

Example 1: Patient has a HepaScore of 0.9 (positive result) and more than 1 elevated analyte level; prevalence of significant fibrosis (METAVIR score ≥2) is 53%. The probability of having a specific METAVIR score is presented in the Table. The PPV is 83.8% and the probability of a false positive is 16.2%.

Example 2: Patient has a HepaScore of 0.2 (negative result) and no elevated analyte concentrations; prevalence of significant fibrosis is 50.1%. The probability of having a specific METAVIR score is presented in the Table. The negative predictive value is 86.4% and the probability of a false negative is 13.6%.

This test is meant as a screening tool to avoid unnecessary biopsies. The lowest and highest scores may obviate the need for a biopsy, while intermediary scores should be interpreted in the overall clinical context of the individual patient.

http://www.questdiagnostics.com/hcp/intguide/jsp/showintguidepage.jsp?fn=TS_LiverFibrosisPnl_HepaScore.htm
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