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Latest trial results April 2014
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Latest trial results April 2014

A must-read for everyone trying to keep up with the fast-paced development of new anti-HCV DAAs (pay particular note to the NIH 6-week trials):
http://www.hcvadvocate.org/news/newsLetter/2014/advocate0414.html#1
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Thank you for posting this link.
I just saw something very promising for my husband should his current treatment fail.

"Gilead
A study conducted in Washington D.C. by the National Institutes of Allergy and Infectious Diseases is shedding some light on interferon- and ribavirin-free DAA therapy in a real world setting to treat people with HCV genotype 1.  The clinical trial was conducted in Washington D.C., and the trial participants were mostly low-income HCV genotype 1 patients.   Many of the patients in the study had negative predictors of treatment response—65-80% male, 80-95% African Americans, 55-85% genotype 1a.  The study was interferon-free and ribavirin-free.  About a quarter of the patients in the study had severe fibrosis or cirrhosis.  All of the patients with cirrhosis were treated for 12 weeks (arm 1).  The three treatment arms (20 patients each) and the cure rates are listed below:
Sovaldi, ledipasvir – 12 weeks –100% cure rates
Sovaldi,  ledipasvir, GS-9669 –6 weeks
—95% cure rate
Sovaldi, ledipasvir, GS-9451 –6 weeks—100% cure rate"

These results are amazing.  Wish ledipasvir was approved by the FDA already.  I will talk to his doctor now about whether he will be a candidate for it, given his personal unique circumstances.

Thanks, Mike.  I REALLY could have used some good and hopeful news right now!

Nan



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