I am noticing my mood change since ive stopped the heavy duty TX drugs,i feel happier and also i went for a bike ride and i notice i have more energy right away...one day free from the TX drugs and i feel a difference....WOW
Yeah, I know you're only serious... ;-) I love lemons too
I love organic lemons and i do notice a big difference in the taste,the commercial lemons are loaded with preservatives....Marica...sure you can,bot ya cant squeeze my lemon...LOL...you know im only serious...reminds of the LED ZEP song
Ron, can I join you eating lems?
Grapefruit and pommelos only are forbidden because of interaction with meds. Pommelo is genetically a grapefruit cross. All other citrus are fine. Literature that recommends grapefruit is not talking about fresh fruit or juice but chemical extracts from grapefruit. I don't know which ones they're playing with but it would never be fresh fruit or juice.
Ritonovir is an AIDS drug that I suspect acts as a helper drug for the 2nd generation PI's, like Riba is a helper drug for interferon.
The new ongoing BOC trials(158) are using ritonavir in tthe mix....this is why they claim its 10 times more potent that the regular BOC trials
I always err on the side of caution,especially when my life depeds on it....no lemons or limes for me...wait a minute....i just finshed 2 years of TX....i think ill eat a box of lems tonite and celebrate
You are a great researcher of information
You requested the link to the info on citrus fruits and the PI drugs.
omg... I was referring to
'My doc just wants me to eat grass and drink water '
You crack me up, thanks for the laugh.... It sure sounds like mooooo to me
"The only citrus that should be avoided when taking meds is grapefruit. "
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There are many others.......
"POTENT INHIBITION BY STAR FRUIT OF HUMAN CYTOCHROME P450 3A (CYP3A) ACTIVITY"
http://dmd.aspetjournals.org/cgi/content/abstract/32/6/581?ijkey=3142833449ed0472aa65ca659aaecdd53316e051&keytype2=tf_ipsecsha
Inhibitory effect of fruit juices on CYP3A activity.
"The inhibitory potential of human CYP3A was in the order: grapefruit > black mulberry > wild grape >pomegranate > black raspberry."
http://dmd.aspetjournals.org/cgi/content/abstract/34/4/521?ijkey=8fc3bc688dccea368d29077e08e6a92230856feb&keytype2=tf_ipsecsha
Grapefruit juice inhibits CYP3A. If you take any medications that are metabolized by CYP43A, inhibiting CYP3A with grapefruit juice can increase the blood level of those meds.
Telepravir and Boceprevir are metabolized by CYP3A. So inhibiting CYP3A with grapefruit juice (or other citrus juices) will increase the blood levels of Telepravir and Boceprevir. The drug Ritonavir also inhibits CYP3A and when they used it together with Telaprevir, the drug levels of Telaprevir increased by 15 fold.
Co
Pharmacokinetic enhancement of the hepatitis C virus protease inhibitors VX-950 and SCH 503034 by co-dosing with ritonavir.
Kempf DJ, Klein C, Chen HJ, Klein LL, Yeung C, Randolph JT, Lau YY, Chovan LE, Guan Z, Hernandez L, Turner TM, Dandliker PJ, Marsh KC.
Inhibitors of hepatitis C virus (HCV) protease have shown marked antiviral activity in short-term clinical studies in HCV-infected individuals. The interaction of the investigational HCV protease inhibitors VX-950 and SCH 503034 with ritonavir, a potent inhibitor of cytochrome P450 3A, was studied in vitro and in vivo. In rat and human liver microsomes, the metabolism of VX-950 and SCH 503034 was strongly inhibited by the presence of 4 microM ritonavir. Upon co-dosing either VX-950 or SCH 503034 with ritonavir in rats, plasma exposure of the HCV protease inhibitors was increased by > 15-fold, and plasma concentrations 8 h after dosing were increased by > 50-fold.
You can sell the blue green bacteria is you want,when you buy the stuff they make you a distrubitor automatic,you just have to buy 4 bottles in advance,now dont get me wrong,im not trying to sell it....even tho i did sell about 10 a few bottles to my friends i actually was giving it away...problem is ,is that it it helps people so weel they dont need it anymore after taking a bottle...its also have for people to belived the stuff kocks A.SS
BTW...i didnt think you were being snarlu at all...i know you by now...your cool, ok in my books
And kids remember: don't drink the koolaid ;)
Dear Doctor Rock
I know you don't sell the pond scum I was just joking around with you (sometimes it's hard to tell on the internet especially because I'm a NY'er and we just have a snarky tone all the time I"m sure).
Oh yeah and I was looking for a quick way to make some cash....I wasn't joking about that ;)
I'm just glad I'm SVR now and can have the lemonade I want to. Actually lemonade and grapefruit juice mixed together sounds pretty delicious if I do say I think I'll go to the grocery store on the way home (and buy some tums too cause that is gonna give me major heartburn I'm SURE)
I dont sell the pond scum....anyone can buy it online or in the local healthstore.i dont own the company
Just call me Dr Rock...LOL
you know there might not be any hard fact scientific data out there specifically about not taking lemons on treatment - how many foods have they specifically studied I wonder but the citrus connection is a connection I guess so maybe people should just limit the intake of anything to the point where it's not THAT much of anything.
Moderation?
Either that or I am going into business with my pal Rocker and selling the blue algae. Ok Rock maybe we should try to make some money while we are at it? :)
" I was told to avoid grapefruit during tx."
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It causes oxidative stress.
Co
after all that can you provide a link that says citrus other then grapefruit is contradicted specifically with HCV treatment meds icluding PI's? Especially telaprevir & boceprevir.
I was told to avoid grapefruit as well as all citrus. They may have been over-cautious throwing in the "all citrus" part tho, imho.
I was staying away from grapefruit anyway because of the Zoloft. I sure do miss it!
Thanks, Rocker, for posting all that. I was curious about the grapefruit-drug interaction, but had not done the research. I was told to avoid grapefruit during tx. Is that a standard of tx, to avoid grapefruit, I mean, is everyone told that by their caregivers? Just curious.
See what i said about the protese drugs and the grapefruit family,its on the above list, i dont know if all PI drugs are the same but im playing it safe
What is Fortovase?
Fortovase is an anti-HIV medication. It is in a category of HIV medications called protease inhibitors (PIs). Fortovase prevents T-cells that have been infected with HIV from producing new HIV.
Drugs That Interact With Grapefruit Juice
Here are some drugs that interact with grapefruit juice. Check with your doctor or pharmacist if you're concerned about any of your medications.
Anxiety: Xanax, Buspar, Versed, Halcion
Depression: Luvox, Zoloft
Allergies: Allegra
Abnormal heart rhythm: Cordarone, quinidine
Heart disease/stroke/blood clots: Coumadin
Epilepsy: Tegretol
Cancer: Cyclophosphamide, etoposide, ifosfamide,
tamoxifen, vinblastine, vincristine
Cough: Dextromethorphan (found in many over-the-counter cold
medicines)
HIV: Agenerase, Crixivan, Viracept, Norvir, Fortovase
Prostate enlargement: Proscar
Heart disease/High blood pressure: Coreg, Cardizem, Plendil, Cardene, Adalat, Procardia, Nimotop, Sular, Covera, Calan, Verelan
Erectile dysfunction: Viagra, Cialis
Asthma/Emphysema: Theophylline
High cholesterol: Lipitor, Lescol, Mevacor, Zocor
Pain: Alfenta, Duragesic, Actiq, Sufenta
Infection: Biaxin, Sporanox, erythromycin, troleandomycin
Patients should check with their doctors about specific interactions between grapefruit juice and medication.