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Liver enzyme
My husband tested positive for TB in 1979, he took meds for 6 months, now enzymes are up. Could this be caused from anything related with TB treatment 34years ago? He is also a diabetic.
Has your husband actually been tested for hepatitis C? How recently? I also took INH when I was in grade school. MANY years ago. I can not take TB skin test because they always show postive due to taking the meds for TB. My liver enzymes were never elevated until I acquired HEP C. I do not know much about TB, I was only exposed to it they said. I definitely would get to a good doc who specializes in the liver. IT is something that needs attention real soon to find out what is causing this problem. I took the INH for 6 months but have never had problems beside the hep c with my liver. Good luck to you and your husband. And by the way tell him the internet can give you too much info sometimes and make you not sure about what conditon you may have.
Sorry to hear that, hope everything is good and full recovery. Have Doctor appt Monday. Have gone crazy with internet, just have to wait and see. Thanks for your help.
Oh wow 200 is high.
With the lab I go to the reference intervals for
AST is 0 - 40
ALT 0 - 32
I am sorry but other than what I just now Googled I do not know anything about TB much less anti-TB medications other than some can be hepatotoxic. In fact I came across the terms
Antituberculosis Drug-Induced Hepatotoxicity (ATDIH)
or
Drug-induced Liver Injury (DILI)
many many times so you are right to be concerned.
I realize you can probably search all over the Internet yourself but I was alarmed when I read that:
The most frequent adverse effects of antituberculosis treatment are hepatotoxicity, skin reactions, gastrointestinal and neurological disorders.
l Hepatotoxicity is potentially the most serious of the above
– Isoniazid hepatotoxicity is the most commonly implicated agent leading to drug-induced acute liver failure in the United States and the most common reason that adults require emergency Liver Transplant for idiosyncratic drug hepatotoxicity.
http://www.tbcontrollers.org/docs/NSTC/2012Meeting/6_Ashkin_062012.pdf
This is why it is crucial you ask your hubby's doctor about treatment alternatives and the best track to take in treating him.
This is very important and I am glad you posted. I just recovered from a bout of medication-induced kidney failure and early detection is the key for things like this.
With the lab I go to the reference intervals for
AST is 0 - 40
ALT 0 - 32
I am sorry but other than what I just now Googled I do not know anything about TB much less anti-TB medications other than some can be hepatotoxic. In fact I came across the terms
Antituberculosis Drug-Induced Hepatotoxicity (ATDIH)
or
Drug-induced Liver Injury (DILI)
many many times so you are right to be concerned.
I realize you can probably search all over the Internet yourself but I was alarmed when I read that:
The most frequent adverse effects of antituberculosis treatment are hepatotoxicity, skin reactions, gastrointestinal and neurological disorders.
l Hepatotoxicity is potentially the most serious of the above
– Isoniazid hepatotoxicity is the most commonly implicated agent leading to drug-induced acute liver failure in the United States and the most common reason that adults require emergency Liver Transplant for idiosyncratic drug hepatotoxicity.
http://www.tbcontrollers.org/docs/NSTC/2012Meeting/6_Ashkin_062012.pdf
This is why it is crucial you ask your hubby's doctor about treatment alternatives and the best track to take in treating him.
This is very important and I am glad you posted. I just recovered from a bout of medication-induced kidney failure and early detection is the key for things like this.
His levels are 200. Had ultrasound today looked normal but have to wait til Monday when he sees the doctor. Hopefully it's just because of medication. Started new meds a few months ago.
What his TB cured by the treatment?
Tuberculous is a bacterial infection that normally infects the lungs although it can damage other organs as well. If he was cured from treatment in 1979 there is no reason to fear the bacteria and its consequences.
TB is an easily cured infection unlike hepatitis C.
What TB treatment drugs did he take? Currently there are 10 drugs approved for the treatment of TB.
He should talk with his physician to get a proper evaluation and if needed diagnosis for any symptoms he is experiencing or any abnormal blood values.
Hector
Tuberculous is a bacterial infection that normally infects the lungs although it can damage other organs as well. If he was cured from treatment in 1979 there is no reason to fear the bacteria and its consequences.
TB is an easily cured infection unlike hepatitis C.
What TB treatment drugs did he take? Currently there are 10 drugs approved for the treatment of TB.
He should talk with his physician to get a proper evaluation and if needed diagnosis for any symptoms he is experiencing or any abnormal blood values.
Hector
Does your husband have Hepatitis C?
Do you mean his enzymes are currently elevated and you are wondering if this is due to the meds he took back in 1979?
Just how elevated are they?
Either way elevated liver enzymes can be caused by lots of things. I am hoping your husband's physician will go over all his medication and habits to find possible causes for this. It is not really easy to respond to questions though I can see you are very concerned. I encourage you to establish communication with the doctor about this.
Do you mean his enzymes are currently elevated and you are wondering if this is due to the meds he took back in 1979?
Just how elevated are they?
Either way elevated liver enzymes can be caused by lots of things. I am hoping your husband's physician will go over all his medication and habits to find possible causes for this. It is not really easy to respond to questions though I can see you are very concerned. I encourage you to establish communication with the doctor about this.
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