Losartan

[Flowerchild700]

Has anyone heard about a study with Losartan, a BP drug, on people with HCV, with moderate Fibrosis?  Its suppose to shrink them, so the liver can heal. I was wondering how I could get on a study like that?  I'm Type1a, a non-responder.

[Bill1954]

The only thing that popped up in a quick trial search regarding HCV/losartan was a Spanish study that has completed in early 2006:

http://clinicaltrials.gov/ct2/show/NCT00298714?cond=hcv&intr=losartan&rank=1

I don’t know if a letter to the principals of this study would yield any information about either the efficacy or availability of future trials.

Good luck—

Bill

[Flowerchild700]

Here's more about what I heard.
http://news.bbc.co.uk/2/hi/uk_news/england/tyne/8076692.stm

[Flowerchild700]

I just thought there might be some more studies going on, maybe in the United States.

[Xhrles]

If you have high blood pressure then ask your doctor to put you on losartan (Cozaar) Not sure what a doctor would do without high BP. You could search clinicaltrials.com but do not think there are any at this time Good luck

[DoubleDose]

There was a recent thread on this forum regarding fibrosis regression and blood pressure drugs (specifically Cozaar, Losartan, etc.  the ARB class).  If you look back over the past month this thread should be available.  There are a variety of related comments in the thread.

I got on Cozaar for my tx induced high BP specifically for this reason!  I had read studies about Cozaar being beneficial for ED, Fibrosis, and depression...and asked my GP to switch me from diuretic style BP drugs to the ARB class.  I did notice benefits in ED function after a few weeks, and also definitely noticed a more positive mood.  I am hoping there will also be an impact on my stage II fibrosis after my SVR, and will do a follow up Fibro-Sure test next year to check for any changes.  I have been on Cozaar for about 16 months now.  

DoubleDose

[Bill1954]

More on losartan:

http://www.medhelp.org/posts/Hepatitis-C/Good-news-for-fibrosis-reversal/show/966789