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4806014 tn?1424501878

Me too! SVR!!! Go Giants!

After 47 years of hcv, two previous tx attempts
here we are SVR!!!

Synergy trial at National Institutes of Health
Sofosbuvir/Ledipasvir & GS9451
6/13 - 7/24/14, Six Weeks, two pills once daily

Viral Load Results:
At screening  6/9/2014      2,680,316>  
Day 1             6/13/14      1,734,728>
2 wks             6/25/14                142>
4 wks             7/09/14                  38>
6 wks             7/28/14      <12 Undetectable End of Treatment

Follow-ups after EOT
<12   8/13/14
<12   9/03/14
<12   9/24/14
<12 10/24/14 - 12-Weeks Post Treatment “SVR”


24 Responses
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317787 tn?1473358451
I am so very happy for you! I just had to come back and say it again,
Congratulations!!! WOO HOO!!! You did it!
Helpful - 0
4806014 tn?1424501878
The second pill was GS9451 a NS3/4 Polymerase Inhibitor. A protease inhibitor that attacks the virus at different sites to prevent resistance.

The one fixed dose Sofosbuvir/Ledipasvir pill I took had not been fda approved yet, as I was in the study in June/July 2014. It was the same pill as the new Harvoni though.

This was an experimental study. They are working on different combinations to shorten duration of tx.
Helpful - 0
4806014 tn?1424501878
Side effects were not too bad. My gall bladder has been giving me trouble for the last 10 yrs and taking a 3 powerful drug cocktail caused severe constipation and some gb pain & inflammation. My food appetite increased X10 and had to eat smaller meals during the 6 wks. Some back and neck pain. Felt a little dizziness but not too bad. There were a lot of GOOD sides on these drugs e.g. increase appetite, itching & leg cramps all vanished during tx, normal labs during tx, My gall bladder survived and gb currently better than ever. Cheers!
Helpful - 0
4806014 tn?1424501878
Thank you all so very much!! I pray you too will feel this joy too!
Helpful - 0
Avatar universal
Congratulations! And now you have a whole brand new life in front of you. Right on!

Do you know what the second pill was? I just wonder since they say you can take Sovaldi/Ledipasvir as just the one pill. Six weeks is pretty nice.
Helpful - 0
Avatar universal
Congrats....any sides?
Helpful - 0
6708370 tn?1471490210
BART was a mess this morning but the rain, the rain was joyful.

The thousands of people who went to the parade, when it started Pouring rain just around noon, they all looked up and cheered!

California is in a major drought, for those who didn't know

Then there was Halloween, Critical Mass, Castro antics, it was a wild day!

I am so happy for you. I can imagine how nice it must be to think about a million things Except for Hep C!

Just think of all those people celebrating You!!! And your great victory! WooHoo!!
Helpful - 0
163305 tn?1333668571
Congrats and hurray for the Giants. The parade today should be amazing , Halloween and world series winners. S.F knows how to celebrate !
Helpful - 0
9683500 tn?1407864284
I'm so happy for you!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!
Helpful - 0
317787 tn?1473358451
Congratulations!! This is wonderful news 6 weeks? Amazing, thanks so much for sharing
Dee
Helpful - 0
4806014 tn?1424501878
You are all so very kind and amazing people. Thank you for your cheerful good wishes! It reminds me that we are all in this together and supporting each other while we deal with these familiar emotions and physical suffering in one form or another. We are all treading new frontiers in a big way these days.          I had to take a long break from posting on this forum. I was really stressed out being in a trial during tx and felt a need to just focus and get through it. Take care everyone! I'm going to do my dragon slayer happy dance!!!
Helpful - 0
4806014 tn?1424501878
Thats right! The games were so much fun to watch, timing to get the svr with the world series win was so wonderful. I really enjoyed watching or listening to those games. For a moment this morning I was seriously debating getting on bart Friday to see the parade..decided not.
Helpful - 0
6708370 tn?1471490210
Congrats!

And, as an added bonus for all your hard work, how about a World Championship too?
Helpful - 0
Avatar universal
That's great news!  Enjoy being dragon free!   Celebrate!!
Helpful - 0
Avatar universal
Wonderful news and a big Congragulations!
Please enjoy your new Hep C free life.
Third times a charm.!!!!!!!
......Kim
Helpful - 0
Avatar universal
You've obviously have paid your dues and now your cured.
Hope it's a new beginning in your life free from Hep C forever.
Wish you the best and a big Congragulations!
.....Kim
Helpful - 0
Avatar universal
Congratulations!!!!

Now step up onto that Dias and receive your Dragon Slayer Supreme Insignia!  

And to think it was only 2 pills, once a day FOR 6 WEEKS!!!

So great.  Enjoy the rest of your - hepc free - life.  : -).    Pat
Helpful - 0
Avatar universal
Congrats, congrats, congrats. Tomorrow is my last dose of S/O. Hope to join you
Helpful - 0
Avatar universal
Way to go! I'm very happy for you.
Helpful - 0
683231 tn?1467323017
Awesome news! Congrats! Doing a happy dance for you!
Helpful - 0
1815939 tn?1377991799
Wonderful news. Congratulations!
Helpful - 0
2059648 tn?1439766665
That's wonderful news
Helpful - 0
4806014 tn?1424501878
Thank you!  And SVR  to you coming soon!
Helpful - 0
Avatar universal
Wow...what a day... Congratulations... Two previous treatments...wow...you really deserve this...soak it in and enjoy...jo
Helpful - 0
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