HEPATITIS C COMMUNITY
My Biopsy results can someone help me understand this

My Biopsy results can someone help me understand this

Diagnosis
    Native Liver ():
- Mild chronic hepatitis with mild fibrosis, consistent with hepatitis c infection
- ISHAK stage 2
Description for chronic hepatitis:
Total grade of inflamation (inflammation) score ( based on A+B+C+D from ISHAK, ref. 1) :5 - mild
A. Portal inflamation (inflammation): 1 - mild,inflammatory infiltrate, some of all triads
B: Interface hepatitis (piecemeal necrosis) : 2 - Focal in most triads
C: Focal (spotty) lobular inflamation (inflammation): 2 2-4 foci per 10x objective
D: Confluent necrosis: - none

Fibrosis (stage) (based on ISHAK. ref. 1) :2
- fibrosis expansion, most triads, with or without septae
DESCRIPTION FOR CELL INJURY / NECROSIS
- cell swelling <1/3 hepatocytes
- microvesicular steatosis: <1/3 hepatocytes
- macrovesicular steatosis: <1/3 hepatocytes
- acidophilic bodies: present
- mallory's Hyalin: absent
- cholestasis: absent
- fibrin/thrombi: absent
- zonal necrosis: absent
- massive necrosis: absent
Special Stain Results:
- iron stain: negative
- pasd:
  - Alpha-1-antitrypsin inclusions: absent
  - Debris in macrophages: absent
- Trichrome stain: Fibrosis
References:
1. ISHAK K et al, Jour Hepatology, 22:696-696, 1995
Clinical history
Hepatitis C.
Gross Description
Received in formalin is a 1.4x0.1 cm tan tissue core and a 0.2 cm tan tissue fragment.
ESS
A-2
Thanks I will listen to any advice Jim




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108191_tn?1199603505
Hi Toughluck,

It looks like you are a stage 2 grade 1.  For me that is the most important area to look at.  The rest of the description is how the analyst came to that number. I am going to embed a clinical description of your biopsy.

___________

"Liver Biopsy

Liver biopsy is not necessary for diagnosis but is helpful for grading the severity of disease and staging the degree of fibrosis and permanent architectural damage. Hematoxylin and eosin stains and Masson
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189269_tn?1189759425
1A Hardest to treat I hear virral load was 1.4 mill
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189269_tn?1189759425
Can you tell from this biopsy possible lenght of time infected and how severe at this time, also if did no treatment how long before I suffer from the disease or die.
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