Avatar universal
NASH
I was resently diagnosed with NASH.  I am 63, very seldom drink alcohol & within normal weight limits.  My liver biopsy came back stating:  Grade of Portal Inflammatory activity 2 out of 4; Grade of Lobular Inflammatory activity 2 out of 4; Stage of Fibrosis 3 out of 4 & 5% macrovesticular steatosis.  Can you explain the "Grades" for me.  My doctor seems rather concerned.  I feel fine except I have gradually become more exhausted & my platelet count has dropped to 104,000 which is causing a lot of bruising.  

Do you have any suggestions?  What is the usual outcome?
Cancel
1 Answers
Page 1 of 1
412873 tn?1329178055
I have been looking into this lately because my sister was also recently diagnosed with NASH-she doesn't drink alcolhol, but is overweight. I haven;t found much information here on MedHelp, but google "fatty liver" and you will get some good information.  From what I have read, diet and excercise are probably the first things to address.  

It is a good idea to see a hepatologist-or at least a GI doctor.  The science of liver disease is constantly changing as new treatments become available and primary care/internal medicine physicians are not always up on the newest protocols.

Below is a copy of an explanation of grades and stages I found in the archives.  Altho grades are listed as letters, not numbers--this will give you a general idea.  Hope it helps :-)
  

Stage 1 Hepatitis -- Inflammation only (hepatitis only)
Stage 2 Hepatitis -- Some scarring (fibrosis)
Stage 3 Hepatitis -- More scarring (more fibrosis)
Stage 4 Hepatitis -- LOTS of fibrosis (cirrhosis)

Once a person gets to Stage 4/Cirrhosis, there are three grades:

Grade A -- Compensated (the liver is doing all it should despite the damage; no apparent symptoms)
Grade B -- DecompensatING (the liver is beginning to not be able to do all its functions; starting to have symptoms)
Grade C -- DecompensatED (liver failure -- the liver cannot perform its own functions; lots of symptoms)

Boils down to:
1. Stage 1 = very little fibrosis
2. Stage 2 = a little more fibrosis
3. Stage 3 = bridging fibrosis
4. Stage 4 = cirrhosis  (Grade A cirrhosis)
5. Grade B cirrhosis
6. Grade C cirrhosis (ESLD)
(Complications like Ascites appear in Grade B cirrhosis).
Comment
Cancel
Comment
Avatar universal
Comment
Comment
Comment
Post Comment
Your Answer
Avatar universal
Answer
Do you know how to answer? Tap here to leave your answer...
Answer
Answer
Post Answer
A
A
Do You Have Hepatitis C? Share Your Experience – Earn Up to $100!
Start by taking this 2-minute survey that will provide more information about where you are in your Hep C treatment journey.

Those who qualify may receive up to $100 for their time.
Explore More In Our Hep C Learning Center
image description
What Is Hepatitis C?
Learn about this treatable virus.
image description
Diagnosing Hepatitis C
Getting tested for this viral infection.
image description
Just Diagnosed? Here’s What’s Next
3 key steps to getting on treatment.
image description
Understanding Hepatitis C Treatment
4 steps to getting on therapy.
image description
Your Guide to Hep C Treatments
What you need to know about Hep C drugs.
image description
Managing Side Effects of Treatment
How the drugs might affect you.
image description
Making Hep C Treatment a Success
These tips may up your chances of a cure.
Recent Activity
20109886 tn?1490346284
Blank
charmingskin12 uploaded a new photo
Apr 25
20109886 tn?1490346284
Blank
charmingskin12 joined this community
Welcome them!
Apr 25
Avatar universal
Blank
Jatt1998 is cool. Comment
Apr 24
Blank
Weight Tracker
Track your weight over time
Start Tracking Now
Top Hepatitis Answerers
317787 tn?1473362051
Blank
DC
163305 tn?1333672171
Blank
Rural Mural, CA
446474 tn?1446351282
Blank
San Francisco, CA
Avatar universal
Blank
1747881 tn?1358189534
Blank
Greeley, CO
2059648 tn?1439770265
Blank
Hepatitis C Community Resources