Neurobiology of Itch / New Product in Germany

[drofi]

Review: http://www.nature.com/nrn/journal/v7/n7/full/nrn1950.html

Endogenous cannabinoids belong to a group of fatty acid amines, the N-acetylethanolamines (NAEs). Biochemical evidence indicates that endogenous NAEs are produced and released by animal and human neurons, and by human epidermal keratinocytes. On local application, cannabinoids have analgesic and antipruritic effects in acute pain and itch models; moreover, there is growing evidence for the suppression of itch by topical cannabinoid receptor agonists under clinical conditions. Direct activation of CB1 and CB2 (but also activity at TRPV1), a new cannabinoid-receptor 'CB2-like receptor' and non-receptor-mediated effects are discussed as possible itch-suppressing mechanisms.
In Germany a product with N-palmitoylethanolamine (PEA, palmidrol, N-(2-hydroxyethyl) hexadecanamide) is already on the market (Physiogel A.I.), prescription free.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Search&db=pubmed&term=+%22Topical+cannabinoid+agonists%22&tool=QuerySuggestion

http://www.physiogel.info/de/physiogel_ai_creme.htm
Physiogel A.I. helps very well against refractory itching , I have own experience with it.
I do not know if a PEA-product is available in the US too. Is it? However, the review is worth to read it, although you need some medical knowledge to understand it.

Regards, Drofi

[Kalio1]

Thanks for the interesting anti itch info. I can't find a source here in the US for it, do you know of a source there that is available online? Possibly that would be a way to get it since it doesn't seem to be available in stores here.

[drofi]

http://www.physiogel.com/int/ is the manufacturer of Physiogel A.I.

It is very expensive here in Germany: about 15 Euro (=20 UD$)for 50ml, don't ask me what they want for export :-(

However, after the second night without sleep, I would give 100 $

drofi

PS: Perhaps you find a manufacturer of pure PEA in the USA and just add it...

[drofi]

they have a lot of Physiogel products for the skin. Only Creme A.I. contains PEA! Only PEA is the new principle against itch!

[GrandmaA]

Is there marijuana in that product?

[drofi]

no

[Pdilly]

How are you doing with your treatment?   This weekend it hit me harder than most but not to bad.

Pat