News Stories - <b>Non-responders take note of first story</b>

This first story is about a repeat non-responder who became SVR after treatment with Multiferon.


<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15362781">Successful application of highly purified natural interferon alpha (multiferon) in a chronic hepatitis C patient resistant to preceding treatment approaches</a>

<a href="http://www.hcvadvocate.org/news/newsRev/2004/HJR-1.17.html#2">HCV Liver Transplant Outcomes</a>

<a href="http://www.hcvadvocate.org/news/newsRev/2004/HJR-1.17.html#3">Post-Transplant HCV Recurrence</a>

<a href="http://www.hcvadvocate.org/news/newsRev/2004/HJR-1.17.html#4">Hepatocellular Carcinoma News</a>

<a href="http://www.natap.org/2004/HCV/101204_06.htm">Interferon treatment improves survival in chronic hepatitis C patients showing biochemical as well as virological responses by preventing liver-related death</a>

<a href="http://www.hivandhepatitis.com/hep_c/news/2004/101504_b.html">Reported Risk Factors Are Useless in Detecting HCV-positive Subjects in the General Population</a>



http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15362781

http://www.hcvadvocate.org/news/newsRev/2004/HJR-1.17.html#2

http://www.hcvadvocate.org/news/newsRev/2004/HJR-1.17.html#3

http://www.hcvadvocate.org/news/newsRev/2004/HJR-1.17.html#4

http://www.natap.org/2004/HCV/101204_06.htm

http://www.hivandhepatitis.com/hep_c/news/2004/101504_b.html

[TnHepGuy_]

<a href="http://www.hivandhepatitis.com/hep_c/news/2004/101304_a.html">Frequent Hepatitis C Virus Superinfection Found in Injection Drug Users</a>

<a href="http://www.hivandhepatitis.com/hep_c/news/2004/101104_a.html">Blood Tests Provide Alternative to Liver Biopsy for Assessing Status of Liver Disease in HCV Patients</a>

<a href="http://www.hivandhepatitis.com/hep_c/news/2004/101104_b.html">The Effects of Interferon Alfa-2b on Blood Platelets in Patients with Chronic Hepatitis C</a>

<a href="http://www.hivandhepatitis.com/hep_c/news/2004/100604_a.html">An Induction Dose of Peginterferon Is a More Effective and Better-tolerated Treatment for Patients with Genotype 1 Than Combination Therapy with High Dose Standard Interferon</a>

<a href="http://www.hivandhepatitis.com/hep_c/news/2004/100604_b.html">Effect of Artificial Liver Support System on Patients with Severe Viral Hepatitis</a>



http://www.hivandhepatitis.com/hep_c/news/2004/101304_a.html

http://www.hivandhepatitis.com/hep_c/news/2004/101104_a.html

http://www.hivandhepatitis.com/hep_c/news/2004/101104_b.html

http://www.hivandhepatitis.com/hep_c/news/2004/100604_a.html

http://www.hivandhepatitis.com/hep_c/news/2004/100604_b.html

[Oreos]

Just want to say THANKS for all your research and informative posts.  

Take good care : )

[Amerabrit]

Just a note to let you know that I never take for granted all of the research you share with the rest of us; Thanks so much.  Shot #37 tonight, right?  I hope you're feeling well and still managing what sometimes sound like really tough sx; stay strong, David you're almost there:).

[cuteus]

I hope Jodi sees that study, and Susan400, wouldn't it be great if it worked in the US studies also? multi interferons and no major sides!

[TravelGrl]

Great Stuff as usual...Thank you!!! I have been investigating the Multiferon for a possible next step if things don't go well this time around.

Your research is greatly appreciated!!

Jodi

[TravelGrl]

Great Stuff as usual...Thank you!!! I have been investigating the Multiferon for a possible next step if things don't go well this time around.

Your research is greatly appreciated!!

Jodi

[DoubleDose]

Just a comment regarding your prior thread indicating an increasing viral load after two weeks of triple therapy for Amanda.

I know that Actimmune (interferon gamma 1-b) had developed a reputation for sending liver enzyme counts very high, when it was used alone or in conjunction with ribavirin in earlier trials.  It also did not seem to lower viral load, when used without other interferons.  Since the LFT's were increased dramatically, MAYBE this also corresponded to an increased viral load.  POSSIBLY this may be what is happening now during the experimental triple tx, along with infergen and ribavirin.  If this is the case, maybe it will prove to be a very short term, sort of a 'flaring' manifestation, and will give way to the opposite effect, and a dramatic drop in viral load.  

I hope that Amanda's doctors can regularly monitor her changing viral load,(maybe even weekly or bi-weekly, during this problem period) to get a better handle on where it is going, and whether it is turning in the other direction.  The triple combination is supposed to be highly synergistic, BUT maybe it has a paradoxical or opposite effect early on in the treatment regime.  Let's all hope that this is what is going on.

Please let us all know what transpires as therapy progresses.  We are all in your, and Amanda's, 'corner', and praying for a positive outcome!  Also, as indicated above, take heart in newer treatments on the way for non-responders.  Possible in the upcoming year or two, new medications like multiferon/ omniferon, plus newly created inhibitors of HCV, and non-anemia inducing ribavirin derivitives may go into trials for non-responders, as an experimental 'coctail' therapy, with much greater impact than any previous therapies.

Amanda will overcome this disease one way or the other, with her tremendous will and spirit, and with the rapidly advancing medical approaches, and with the tremendous support and caring from all those around Amanda, including all the members of this forum!
We are with the two of you!

Doubledose