Non Hodgkin's Lymphoma Test Report

Hello,
i hope i would get some help from this forum
my cousin who is 33 old has Chronicle Hep C , he tried some kind of interferon+something treatment which made
his health very weak and he had to stop the treatment after that he is not well he gets fever very often and feel very
weak sometime he feel very hard to breath, cough etc...
so he went to Dr and had this test called Non Hodgkin's Lymphoma
below is the report if somebody can explain me the report i would really appreciate that i have read a little bit about
NHL on this forum and would be reading more ... (NOTE: he had 2 tests because once it was not preserved properly that is what the Dr says)
here is the detailed report:

*******************First report******************************:

CLINICAL DETAILS: Diagnosed as Non-Hodgkin's lymphoma. Bone marrow slides received for second opinion.  
PERIPHERAL BLOOD COUNTS:
HB:              13.6 G/DL
HCT:             38.6 %
MCV:             91.9 FL
MCH:             32.4 PG
WBC'S:           2.7 x 10E9/L
ANC:             0.5 x 10E9/L
PLATELETS:       157 x 10E9/L

CORRECTED RETICULOCYTES COUNT: Not suitable for reporting.
RESULTS OF DIRECT COMB TEST: Negative.

PERIPHERAL BLOOD FILM: Shows anisocytosis and poikilocytosis. There is leukopenia with neutropenia. Platelets are normal on film.

BONE MARROW ASPIRATE: Dilute marrow showing predominantly [34800.00]atypical lymphoid cells. Myeloid precursors seen. No apparent [37200.00]erythroid precursor or megakaryocytes noted. No [28800.00]non-haematopoietic cell or haemoparasites seen.

BONE TREPHINE TOUCH PREP: Hypocellular smear showing [31800.00]predominantly atypical lymphoid cells.

RESULT OF BONE TREPHINE (H&E) SECTION: Good length specimen [36000.00]showing poorly preserved material. However, overall cellularity [38400.00]is around 75 to 80%. Cellular areas show presence of multiple [37200.00]lymphoid aggregates. Normal haematopoiesis is appreciated [34800.00]comprising of erythroid and myeloiod precursors. Megakaryocyt

RESULT OF BONE TREPHINE (H&E) SECTION: Good length specimen [36000.00]showing poorly preserved material. However, overall cellularity [38400.00]is around 75 to 80%. Cellular areas show presence of multiple [37200.00]lymphoid aggregates. Normal haematopoiesis is appreciated [34800.00]comprising of erythroid and myeloiod precursors. Megakaryocyt

TDT: Negative. [9000.00]RESULTS OF RETICULIN STAINS: Not suitable for reporting.

OPINION: Not diagnostic. Bone marrow is dilute while bone [34800.00]trephine is a poorly preserved specimen. Biopsy of accessible [37200.00]lymph node is recommended for further evaluation. [30000.00]Suggest cellular bone marrow with a good length bone trephine if [39000.00]clinically indicated, which will be processed free of charge on

the same HN number.[11400.00]Note: This case has also been reviewed by our consultant [34200.00]histopathologist, Professor Dr. Shahid Pervez and he concurs [36600.00]with the opinion.

************************************Seond Report*******************************************************:

PERIPHERAL BLOOD COUNTS:
HB:             13.6 G/DL
HCT:            35.3 %
MCV:            90.1 FL
MCH:            34.7 PG
WBC'S:           2.3 x 10E9/L
ANC:             0.2 x 10E9/L
PLATELETS:       126 x 10E9/L

PERIPHERAL BLOOD FILM: Reveals normocytic and normochromic red blood cells. Red blood cell agglutination seen. There is neutropenia and leukopenia. There is lymphocytosis with 20% atypical lymphocytes seen. Platelets are low on film.

RESULTS OF DIRECT COOMB'S TEST: 2+ positive.

BONE MARROW ASPIRATE: Hypocellular specimen showing predominantly lymphoid cells comprising of 55% of the total non erythroid nucleated cell population. These lymphoid cells are small to medium in size with high nuclear to cytoplasmic ratio, clumped chromatin and scanty agranular cytoplasm.Few of these

lymphoid cells show cleaving of nuclei. Myeloid and erythroid precursors noted. M:E ratio is 3:1. Occasional megakaryocytes seen. Blast cells are less than 5%. Plasma cells are less than 3%. No non-haematopoietic cells, clumps or haemoparasite identified.

BONE TREPHINE TOUCH PREP: Not suitable for reporting.

RESULT OF BONE TREPHINE (H&E) SECTION: Small length specimen showing effaced architecture and hypercellularity for age. Overall, cellularity is around 85-90%. Cellular areas show infiltration with lymphoid cells. Residual haematopoiesis is markedly suppressed. Occasional megakaryocytes seen.

RESULTS OF IMMUNOHISTOCHEMISTR:
CD20:Negative
CD5: Positive
CD3: Positive
Tdt: Negative

OPINION: Findings are consistent with T-lymphocytosis which may be reactive. Possibility of mature T-cell lymphoproliferative disorder can not be excluded on the material examined. Suggest biopsy of any accessible lymph node.

[HectorSF]

Non-Hodgkin's lymphoma is cancer of the lymphoid tissue. Your cousin has much more serious health issue then hepatitis C. We are not experienced with this disease and it is not related to his having hepatitis C.

Please post this over on the "Leukemia - Lymphoma Community".
http://www.medhelp.org/forums/Leukemia--Lymphoma-/show/139

Hope they can help you.

Hector

[cheesenrice]

there are quite a few cases of nhl developing from hep c - those with hep c are around 30% more likely to develope it than those who arent infected

[GuJrAnWaLiAn]

Thanks very much for your reply . i'll post there.

[GuJrAnWaLiAn]

nobody is replying there so if anybody can explain the report to me please ??? Thanks