OK, here are the numbers. I don't understand any of this.

[paxman9270]

Here are the numbers that are "abnormal" for my fiancee:
ALK PHOS 159H (25-138)
AST      112H (15-40)
GGT      72H  (00-53)
ALT      115H (04-47)
High Sensi CRP 13.85Hf   (0.00-5.00) (high cardiac risk over 10)
Here's the other stuff that seems important:
HBs Ag  Non-Reactive
HCV copies/ml 1554114
HCV IU/ml 298868
ANGIO CONV ENZ @ 115H  (12-68)
SED rate (weste) 27H  (0-25)
The atypical pANCA pattern has been observed in a significant percentage of patients with ulcerative colitus, (she has), primary sclersoing cholangitis (??), and autoimmune hepatitis.
Is there a genotype of 2f?  That's the only type of thing on the report that i can see.  CYC.CIT.PEP.IGG @ 2f  
Thanks for your help and support

[Bill1954]

Ok, yeah, you

[paxman9270]

Ok, so you're saying that if after twelve weeks, the test shows less than a 2 log reduction, AND IF Her biopsy is zero to two, then it MIGHT be wiser to wait for the better meds in a few years? a whole lot of if's there.

[ladybug52]

You've done it again. I had my daughter who will graduate next month as a middle school math teacher help me figure out viral load and log drops. She calculated it for me but you did a nice job of explaining it. I don't think I understand it yet, but I'm not trying. It's a great reference tool for next time, when she's not around. Thanks,
Bug

[paxman9270]

I should check out fatty liver too, i guess.  She's 5 foot 2 and 170 pounds. I'm 5 foot 9 and 265 pounds.

[paxman9270]

That's alot to wrap around my brain, but I'll try to absorb that and give her the 'lite' version when I call her in the morning.  Thanks.

[Bill1954]

Hi there, Paxman,

There

[paxman9270]

Ah, but what does the log MEAN? i could say 13.5 times ten to the sixth but it means the same. Is it just an easier notation? just wondering. I don't want to sound like a know it all when she goes to her appointment.

[Bill1954]

(Sshhh; don't tell anyone...) The fastest way too calc log value is with a scientific calulator. You probably have one in your computer if you know where to look. Just enter the numerical value, say 13,500,000 then hit the log key. That's all there is to it. In this case we get a log value of...7.13. Now you too can be look cool without knowing diddly squat about medicine!

[madbrad]

  
Abnormal Liver
Abnormal Liver Function Tests



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Introduction
One of the most common ways a person finds out about a possible problem with their liver is the discovery of elevated liver function tests. Very frequently, this occurs during blood testing for life or health insurance, or when seeing a doctor for another reason.

For example, a healthy 45-year-old man called Mr. Jones had his blood drawn as part of a screening exam for additional life insurance. The insurance company told Mr. Jones that he was ineligible because he had abnormal liver function tests. So Mr. Jones called me, explaining the problem and nervously asking what it means to have elevated liver function tests. I explained to him that it was not a medical condition in and of itself, and that I could only establish the significance of blood test results after obtaining a complete history, examining him, and reviewing the precise test results.

The following week, Mr. Jones came to my office. He told me that he felt well, worked hard at his job, and exercised regularly. He admitted that he had used intravenous drugs a few times, about 20 years previously. He told me that he currently drinks a couple of beers most days and a six pack or more some weekends. He was not taking any medications and had no other complaints. He was about 25 pounds above his ideal body weight, but otherwise his physical examination was entirely normal.

I looked over the laboratory test report from the insurance physical and noted that two test results were abnormal: alanine aminotransferase (ALT) and aspartateaminotransferase (AST). The older names for these enzymes, still used by some doctors and clinical laboratories, are SGPT and SGOT, respectively. Other laboratory test results, including the alkaline phosphatase, gamma-glutamyltranspeptides (GGT), bilirubin, albumin, and prothrombin time were normal.

Liver Function Tests are not Liver Function Tests

I initially told Mr. Jones the same thing I tell the first- and second-year medical students at Columbia: Liver function tests, also sometimes called liver enzymes, are not liver function tests. For reasons that are unclear, the activities of certain enzymes in the blood, usually ALT and AST, and sometimes alkaline phosphatase and GGT, are incorrectly referred to as liver function tests or LFTs. Some people even refer to them as liver count. I don

[desrt]

That's hard being AIH/HCV co-infected - the treatments for each is contraindicated for the other. What is her doc recommending she do?

[paxman9270]

OK, we'll see what the next blood test says.  Anyone else know what the other abnormal levels mean?  Thanks, madbrad.

[madbrad]

All I know is your liver enzymes are over double..Which indicates liver cell damage...The liver cell produce enzymes when they die. I do see there over a million and half copies of virus...Which is alot but not outrageous,that will drop quick in tx..I don't see the genotype stated...It usually takes a few weeks to get those back......