Aa
A
A
Close
Avatar_universal
Occult/persistent HCV paper
"Patterns of viraemia in haemodialysis patients with hepatitis C

Clinical features, aminotransferases levels, and antibody to HCV have only limited correlation with the activity of liver disease and cannot accurately predict persistence versus eradication of the virus in haemodialysis patients. Although permanent loss of serum HCV RNA appears to correlate with resolution of the disease, little is known about the predictive value of a single HCV RNA value. The aim of the study was to evaluate the viraemia in the serum of HCV antibody positive haemodialysis patients during a period of 3 years. The study group consisted of 65 HCV antibody positive patients from our dialysis unit. HCV antibodies were measured every 6 months by ELISA third-generation assay. The presence of serum HCV RNA was assessed by reverse-transcriptase polymerase chain reaction (RT-PCR) once a year during the period of 3 years. Serum levels of aminotransferases were measured monthly with standard automated analyzers. There were three different patterns of viraemia after the third assesment of the serum HCV RNA in HCV antibody positive patients: 47% (30/65) were persistently HCV RNA positive, 38% (25/65) were intermittently HCV RNA positive, and 15% (10/65) were persistently HCV RNA negative. The dominant genotype was 1a, detected in 97% of the patients positive for HCV RNA. The HCV RNA persistently positive patients had significantly higher levels of ALT compared to HCV RNA persistently negative patients (50.07 +/- 30.0 vs. 28.5 +/- 10.0 U/L, p < 0.027). There was no significant difference between the three groups of patients according to age, haemodialysis duration, and serum levels of AST. This pattern of intermittent viraemia clearly showed that a single negative result of the presence of serum HCV RNA in an HCV antibody positive patient should not be taken as a proof of a persistent resolution of HCV. Thus, repeated testing for HCV RNA is necessary to assess viraemia accurately in HCV antibody positive patients. HCV antibody positive patients who were persistently serum HCV RNA negative could be potentially infectious because of the possibility of the persistence of occult hepatitis C."

http://www.ncbi.nlm.nih.gov/pubmed/19259047?ordinalpos=1&itool=Email.EmailReport.Pubmed_ReportSelector.Pubmed_RVDocSum

(full text of article here:   http://e20.manu.edu.mk/prilozi/14d.pdf  )


TnHepGuy
Cancel
0 Answers
Page 1 of 1
Your Answer
Avatar_universal
Answer
Know how to answer? Tap here to leave your answer...
Answer
Occult/persistent HCV paper
Submit Answer
A
A
Recent Activity
4059843_tn?1454481984
Blank
mishymoshymarcy commented on need a title -
5 hrs ago
134578_tn?1446090952
Blank
AnnieBrooke commented on need a title -
5 hrs ago
3060903_tn?1398568723
Blank
need a title -
6 hrs ago by Nighthawk61
Blank
Weight Tracker
Track your weight over time
Start Tracking Now
Top Hepatitis Answerers
446474_tn?1446351282
Blank
HectorSF
San Francisco, CA
1815939_tn?1377995399
Blank
pooh55811
317787_tn?1428318779
Blank
Dee1956
DC
Avatar_m_tn
Blank
can-do-man
IN
163305_tn?1333672171
Blank
orphanedhawk
Rural Mural, CA
683231_tn?1438659664
Blank
flyinlynn
Auburn, WA
Hepatitis C Community Resources
Top Hepatitis Answerers
446474_tn?1446351282
Blank
HectorSF
San Francisco, CA
1815939_tn?1377995399
Blank
pooh55811
317787_tn?1428318779
Blank
Dee1956
DC
Avatar_m_tn
Blank
can-do-man
IN
163305_tn?1333672171
Blank
orphanedhawk
Rural Mural, CA
683231_tn?1438659664
Blank
flyinlynn
Auburn, WA