On Treatment question about telaprevir , reply much appreciated
Hi I have on the triple therapy , peg , rib , telaprevir now for just over 3 weeks ,
My question is with telaprevir and the 20 grams of fat , I usually have a meal or snack with 20 to 30 grams of fat with each dose of telaprevir , sometimes when I am on the road for work , I may stop at maccas and have a quarter pounder and fries which comes to about 50 grams of fat , is that okay ? that amount of fat to be taken with teleprevir ?
Replies appreciated .
I drank a glass of "whole" milk with the pills. No where near 20 grams of fat but still worked. Studies have shown fat helps absorption of Telap so it is best to take with some fat, if possible. But I think it is somewhat over stated, the same way drinking half of body weight in OZ's of water.
There have been no studies of drinking water. As a matter of fact some top hep docs think to much water dilutes the meds making less effective.
The systemic exposure (AUC) to telaprevir was increased by 237% when telaprevir was administered with a standard fat meal (containing 533 kcal and 21 g fat) compared to when telaprevir was administered under fasting conditions. In addition, the type of meal significantly affects exposure to telaprevir. Relative to fasting, when telaprevir was administered with a low-fat meal (249 kcal, 3.6 g fat) and a high-fat meal (928 kcal, 56 g fat), the systemic exposure (AUC) to telaprevir was increased by approximately 117% and 330%, respectively. Doses of INCIVEK were administered within 30 minutes of completing a meal or snack containing approximately 20 grams of fat in the Phase 3 trials. Therefore, INCIVEK should always be taken with food (not low fat)
How should I take INCIVEK?
Take INCIVEK exactly as your healthcare provider tells you. Your healthcare provider will tell you how much INCIVEK to take and when to take it.
Take INCIVEK 3 times a day. Each dose should be taken 7 to 9 hours apart. Eat a meal or snack that contains about 20 grams of fat, within 30 minutes before you take each dose of INCIVEK. Talk to your healthcare provider about examples of foods that you can eat that contain about 20 grams of fat. Always take INCIVEK with food.
20 grams of fat = better safe than sorry, why risk it
Hey I remember you! Looks like you decided to take care of your commitments before you treated. Anywho, the huge fold out prescription insert ("Full Prescribing Information and Medication Guide) that comes in the blue & white box of Incivek says take with food (not low in fat) but elsewhere on the same fold out it says to eat a meal or snack that contains about 20 grams of fat.
Wow that FDA link is a huge file but there is lots of good info .
Here is the section about fat but the one below it is even more interesting. It explains how Incivek is developed to attack the wild-type and lower level resistant variants.....leaving the complimentary role of Peg/Riba to eradicate the ...rest (it gets more detailed but I don't want to totally hijack your thread).
These drugs are a huge commitment and there is alot at stake.
I'm pleased the "milk" worked for you but please don't suggest to others they do the same.
There is a specific reason the drug company wants you to take the fast with the drugs. The systemic exposure to telaprevir was increased by 237%.
who doesnt want that? It's not to make things harder for us.
12 weeks of fat is a small price to pay for a life free of hcv
I was diligent with my fat, measuring with every dose.
I'll never be able to eat hagen daz vanilla ice cream again but
I am now 7 months post treatment and "cured"
Stick with the outlined program!
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