PF-868554 polymerase inhibitor

[DragonSlayer45]

Do any of you have any experience or info on Pfizers polymerase inhibitor PF-868554? I Have been trying to find out a little more information about it and there does not seem to be a whole lot out there on it. It is supposedly pretty far along in trials (Phase 2) and they are going to be conducting another soon as my doctors office called to see if I was interested. I had heard of it but was not really well versed on it. I have been trying to find a little more out but the information appears to be limited. I did find a little and am curious about the Adverse Effects (AE) namely any gastro intestinal (GI) problems associated with it. I know that NM 283 was stopped because of the problems they had with GI sides. What I saw seemed to show some problems with it on this drug also. I have also been watching Pharmasett's R7128 which had excellent results in an early trial and no adverse sides or viral mutations. If anyone has any information or can point me in the right direction I appreciate it.

[willing]

from clinicaltrials.gov it looks like pfizer is recruiting for two phase 1 studies of PF-868554 so I would assume there's not much data on anti-viral effect yet (that makes it an easy decision, heh..)

Here's a couple of papers on ns5b inhibitors being worked on by their guys in '05.  It may be worth searching through - sometimes the drug code numbers are already set in the early research literature

http://www.ncbi.nlm.nih.gov/pubmed/15863301
http://www.ncbi.nlm.nih.gov/pubmed/15911260

Also, for everyone pondering drug resistance, the following short, free access, article gives a good overview, in particular of what's been learned from HIV PIs treatment. Note the warning against "avoidance of weak sequential monotherapies".

http://jac.oxfordjournals.org/cgi/content/full/dkn175v1

[DragonSlayer45]

sorry I meant to say 99% reduction in VL

[DragonSlayer45]

I agree that R7128 looks really promising from the initial trial. I have been interested in it as it had a 99% VL at week 4 and 81% cleared. There was no AE to treatment and no viral mutations found. It was a small trial but promising just the same.

my doctors office called me about the Pfizer trail for PF-868554 but I can't find a whole lot of info. I told them I would like to learn a little more about it. In the meantime I am just trying to see what I can find out on my own.

[willing]

I followed the pharmasset r7128 up a bit and confirmed they were only enrolling tx naive at this point. Agreed that it looks very promising.