PLN do you have your VL results back yet?

[mremeet]

Just wondering how your results panned out.

[pln]

No, and I am on pins and needles. APK, how long did it take for your end of TX pcr to come back? Thanks. Pam

[APKhaos]

Pam,
This is how it went for me:

- Clinic visit on the Monday of week 21 I learned which dosing arm I was in.
- Had to wait until the PCR results from that visit were avaiable, which was around 9 days.
- After the 9 days, the one page summary of every PCR from the first screening visit through to the week 20 results was released. I got it by fax from my clinic.
- Since then, the twice a month follow up PCR results are provided with the rest of the lab results every two weeks.

Hope that helps - sorry I've been off the board for a few days, so missed your question.

[mremeet]

Pam I got the word you were UND, congrats! I knew you'd pull through, the LFT's are just quirking out on you a little, that's all. They'll probably go back down real soon, but if they don't, now you know for sure it does NOT necessarily mean relapse at all. Anyway, glad to hear you're in money - I think you're gonna stay that way!

APK - I was also wondering if you were UND since stopping treatment? As you're obviously ahead of all us you would have been the first to receive your first post tx VL results. I'm surprised you haven't posted your results yet, 'figgered you'd be all over it by now. ;-)

[APKhaos]

I'm still UND, but that's only one PCR at week 26. Just did the week 28 follow-up today, so will know mid next week.

The PCR one month after end of tx probably doesn't mean much. Its the six month PCR that really counts, right?

[jmjm530]

APK: The PCR one month after end of tx probably doesn't mean much. Its the six month PCR that really counts, right?
--------------------------------------------
On SOC, most relapses occur fairly soon after stopping the treatment drugs, and in fact the one month post tx PCR correlates about 90% with the six-month (SVR) -- so it is quite meaningful. It's still to be seen if this 90% figure translates over to someone who treated with SOC plus VX-950 but I personally don't see a strong reason why it won't. All the best luck with your PCR and let us know how it goes.

-- Jim

[APKhaos]

Jim said,"On SOC, most relapses occur fairly soon after stopping the treatment drugs, and in fact the one month post tx PCR correlates about 90% with the six-month (SVR) -- so it is quite meaningful. <snip>

Thanks for that insight Jim! Did not realize that there was any significant correlation between the one month post-tx PCR and the six month PCR. Great news!! Still, we'll be watching and waiting until the six month PCR, and probably doing the same until the 12 month PCR. Don't want to even breathe the C word anywhere near the family until its rock solid. Still, your news is the best I've heard in a while, so thanks again.

[jmjm530]

And the 12 week post SOC tx PCR correlates around 98 per cent with SVR. BTW I know how you feel about the "C" word as I approach my 1 year post tx PCR. However, being negative at 3, 6, 12, 24 and 36 weeks post tx does give me a lot of confidence.

Be well.

-- Jim